Flow boiling in microchannel has been receiving a lot of attention in recent years because of its high heat flux removal capabilities at low flow rates and low pumping power. An important aspect of flow-boiling experiments is detection of the prevalent flow-regime. Currently, most researchers use high-speed camera for flow visualization for regime detection. However, in some cases due to limitations of the experimental setup and test-piece, such as multilayer cooling of 3D IC stack, this may not be feasible. We study the influence of flow-regime on amplitude-frequency domain of wetted surface temperature. Experiments have been performed along with high speed flow visualization on a single microchannel having dimensions of 25.4 x 2.54 x 0.4 mm 3 (l x b x h) with de-ionized water as the working fluid. Mass fluxes tested were 200 and 600 kg/(m 2 s). Within the bounds of current experimental parameters, we conclude that local transient temperature data can a potential diagnostic tool for detection of flow-regimes.