In order to improve the working performance of the impeller in a multi-phase pump under different working conditions and expand the range of the high-efficiency areas of the multi-phase pump, each section of the impeller was divided into an inlet section, middle section and outlet section. The pressurization performance of different areas within the impeller was obtained by numerical calculation under different flow rates and different gas volume fractions, respectively. The results show that the pressurization performance of the different areas within the impeller can be predicted well. In the first half of the impeller, when the blades were closer to the rim, the pressurization performance was stronger, and in the second half of the impeller, when the blades were closer to the hub, the pressurization performance was stronger. With an increase in the flow rate, from the inlet section to the outlet section, the pressurization performance of each stage of the impeller gradually decreased, and the strongest pressurization performance area was always in the inlet section with no obvious movement. With the increase in the gas volume fractions, the pressurization value of each stage of the impeller dropped faster, except for the outlet section. When there was an increase in the flow rate or the gas volume fraction, the inlet section was influenced the most and the outlet section was influenced the least. The research results provide an important theoretical basis for further optimization of the impeller design for a multi-phase pump.