In recent years, Distributed Acoustic Sensing (DAS) deployed in deviated wells has been increasingly used for microseismic monitoring. DAS can provide observations of microseismic wavefields with high spatial resolution and wide aperture, at the cost of unusually large data volumes compared with conventional downhole microseismic monitoring. To tackle this big-data challenge, we have developed key elements of a processing workflow that is assisted by machine learning techniques. We trained a convolutional neural network (CNN) for event detection and a U-Net model for both P- and S-wave arrival time picking. The workflow was applied to two multiwell DAS datasets acquired during hydraulic fracturing completions in western Canada. These datasets also include co-located 3C borehole geophone arrays that enable further comparison between catalogs from both sensor types. Compared with a traditional short-term average/long-term average (STA/LTA) method for event detection, our results indicate that the CNN method has a lower false-trigger rate and increases the event catalog size by a factor of 2.6–5.6. U-Net yields arrival-time picks with relatively small errors, high efficiency, and minimal user intervention, providing hypocenter location and focal depth that is arguably more accurate than the geophone catalog. While the proposed automated workflow requires substantial effort to build high-quality and large training datasets, it enables the use of DAS for real-time seismicity monitoring and risk management after the training stage. Although the DAS system detected fewer events than the geophone catalog and missed smaller magnitude events, our results indicate that fiber-optic sensors provide enough sensitivity to detect and locate sufficient events to characterize the treatment stages. DAS also captured induced events located at a hypocentral distance of >1 km, which are possibly indicative of reactivation of structural features.