2022
DOI: 10.1016/j.heliyon.2022.e11685
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Hydro-ethanolic extract of Khaya grandifoliola attenuates heavy metals-induced hepato-renal injury in rats by reducing oxidative stress and metals-bioaccumulation

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Cited by 6 publications
(3 citation statements)
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“…This led to oxidative stress-induced tissue damage due to exposure to these toxic substances. 7 Metal chelating agents are commonly employed for treating heavy metal poisoning by competitively binding metal ions using ligands within living organisms. This process forms stable, non-toxic, water-soluble chelates, which are subsequently excreted via urine or bile pathways.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…This led to oxidative stress-induced tissue damage due to exposure to these toxic substances. 7 Metal chelating agents are commonly employed for treating heavy metal poisoning by competitively binding metal ions using ligands within living organisms. This process forms stable, non-toxic, water-soluble chelates, which are subsequently excreted via urine or bile pathways.…”
Section: Introductionmentioning
confidence: 99%
“…Some chelating agents can even traverse the placenta or breast milk, exerting detrimental effects on the health of fetuses and children. 7 Hence, it is imperative to urgently discover novel heavy metal therapeutic agents that are safe, efficient, and devoid of toxic side effects in order to safeguard vital organs such as the kidneys and liver.…”
Section: Introductionmentioning
confidence: 99%
“…Confirmando essa tendência, nossos resultados mostraram uma diminuição na atividade enzimática da CAT nos animais do grupo Pb em relação aos animais do grupo CTR. CAT é uma enzima da linha de defesa antioxidante dos tecidos combatente de peróxido de hidrogênio, convertendo-o em água (H2O) e oxigênio (O 2 ) (Ighodaro & Akinloye, 2018;Kouam et al, 2022). Assim, a diminuição na sua atividade pode resultar em aumentos nos níveis de danos em exposições mais prolongadas.…”
Section: Ctr Pbunclassified