Pakistan is home to three of the world's largest mountain ranges in the Upper Indus Basin (UIB), where the majority of Pakistan's water resources are located: the Himalayan, Karakorum, and Hindu-Kush. This work estimated the (snow+glacier) and rainfall runoff from one of the major tributaries, the Gilgit River, nestled within the UIB of Pakistan. The snowmelt runoff model (SRM) derived by the cryospheric data from the MODIS (moderate resolution imaging spectroradiometer) was employed to predict the daily discharges of the Gilgit. The SRM was successfully calibrated, and the simulation was undertaken from 2005 to 2010, with a coefficient of model efficiency ranging from 0.84-0.94. The average contributions of (snow+glacier) and rainfall to the stream flows of the Gilgit from 2001-10 were 78.35% and 21.65%, respectively, derived from the SRM. The representative concentration pathways (RCP) 4.5 and 8.5 scenarios of the Intergovernmental Panel on Climate Change (IPCC) AR5 were used to investigate the effects of the changes in temperature on climate of the Gilgit catchment. Under the RCP 4.5 scenario, the air temperature