Hydroa vacciniforme–like cutaneous T-cell lymphoma: Clinicopathologic and immunohistochemical study of 12 cases

Sangüeza, Martín; Plaza, Jose A.

doi:10.1016/j.jaad.2013.01.037

Cited by 68 publications

(48 citation statements)

References 18 publications

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“…Although cytotoxic proteins are constantly positive, 13,17 a proportion of neoplastic cells in our series expressed CD4 in 3 cases (one of them positive also for CD8). These findings expand on previous observations that showed CD8 positivity in the majority of cases, 13,17,27 suggesting that phenotypic variants can be observed in HVLL, just as in any other type of cutaneous or extracutaneous lymphoma. Positivity for CD56 was observed in 5 of 9 of our patients, similar to what observed in other series or case reports 8,17,22,28 but different from the negativity of all Bolivian cases.…”

Section: Discussionsupporting

confidence: 89%

“…Positivity for CD56 was observed in 5 of 9 of our patients, similar to what observed in other series or case reports 8,17,22,28 but different from the negativity of all Bolivian cases. 13,14 The prognosis of HVLL is variable. Although the disease may be limited to the skin for several years, patients with systemic involvement have an aggressive course with rapid progression.…”

Section: Discussionmentioning

confidence: 99%

“…7 Several studies on clinicopathologic, phenotypic, and molecular features of HVLL have been published. [8][9][10][11][12][13][14] HVLL was initially interpreted as an association of hydroa vacciniforme (HV) and non-Hodgkin lymphoma 15,16 or as an inflammatory disorder. 2 Nowadays, it is clear that it represents a primary CTCL with a prolonged but usually fatal course.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathologic Features of Hydroa Vacciniforme–Like Lymphoma

Magaña

Massone

Magaña

et al. 2016

The American Journal of Dermatopathology

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Hydroa vacciniforme-like lymphoma is a recently recognized cutaneous T-cell lymphoma associated with Epstein-Barr virus. The disease is observed in children of Latin American or Asian ethnicity. The authors report the clinical, histopathological, and immunophenotypical features of 9 new Mexican patients (M:F = 2:1; mean age, 14.5 years; median age, 13.3 years; age range, 4-27 years), expanding on previous observations of this elusive disease. The most common clinical aspects were persistent facial edema with necroses and pitted scars. Histopathological analyses revealed variably dense lymphoid infiltrates with common angiodestructive features. Neoplastic cells expressed CD3 and cytotoxic markers in all cases and were constantly positive for Epstein-Barr virus (EBER-1). Expression of other markers was variable. Follow-up data revealed that all patients died within 6 months or less, thus showing a very aggressive course with poor prognosis.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinicopathologic Features of Hydroa Vacciniforme–Like Lymphoma

Magaña

Massone

Magaña

et al. 2016

The American Journal of Dermatopathology

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“…1,2 This histopathologic feature has also been recently reported in primary cutaneous gamma-delta T-cell lymphoma, 3 hydroa vacciniforme-like lymphoma, 4,5 and in a small percentage (about 15%) of primary cutaneous anaplastic large-cell lymphoma (PCALCL). 6 It has also been observed in rare cases of adult T-cell cutaneous leukemia/lymphoma.…”

Section: Introductionsupporting

confidence: 52%

Chronic Reparative Changes in Medium-Sized Vessels in a Case of Primary Cutaneous Anaplastic Large-Cell Lymphoma With Angioinvasive Features and Cytotoxic Phenotype

Macarenco

Oliveira

2015

The American Journal of Dermatopathology

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Angioinvasion/angiodestruction has been reported in a small subset of primary cutaneous anaplastic large-cell lymphomas (PCALCL). Recently, PCALCL with angioinvasive features and cytotoxic phenotype has been characterized as a variant associated with good clinical outcomes despite worrisome histopathologic features. We report a case of PCALCL with angioinvasive features and cytotoxic phenotype associated with reparative changes on the wall of medium-sized vessels involved by the neoplasm, including intimal fibroblastic proliferation and luminal obliteration. This vascular pattern, although previously unreported in PCALCL, is in accordance with the indolent behavior observed in this entity and provides a further link with lymphomatoid papulosis type E.

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“…mosquito bites. Histology is characterized by variably dense lymphoid infiltrates with atypical lymphocytes (atypia may be minimal in some cases, however), involving the entire dermis and in some HYDROA VACCINIFORME-LIKE LYMPHOMA A rare, peculiar NK/T-cell lymphoma affecting mainly children and resembling hydroa vacciniforme clinically has been described in Latin American (particularly Mexico, Guatemala, and Peru) and some Asiatic countries (China, Japan, Korea, and Taiwan) [18][19][20][21][22][23][24][25][26][27][28]. 10.5).…”

Section: Treatment Guidelinesmentioning

confidence: 99%

Other Cutaneous NK/T‐Cell Lymphomas

2014

Skin Lymphoma

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Hydroa vacciniforme–like cutaneous T-cell lymphoma: Clinicopathologic and immunohistochemical study of 12 cases

Cited by 68 publications

References 18 publications

Clinicopathologic Features of Hydroa Vacciniforme–Like Lymphoma

Clinicopathologic Features of Hydroa Vacciniforme–Like Lymphoma

Chronic Reparative Changes in Medium-Sized Vessels in a Case of Primary Cutaneous Anaplastic Large-Cell Lymphoma With Angioinvasive Features and Cytotoxic Phenotype

Other Cutaneous NK/T‐Cell Lymphomas

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