Hydroalcoholic extract of<i>Myrtus communis</i>can alter anxiety and sleep parameters: a behavioural and EEG sleep pattern study in mice and rats

Hajiaghaee, Reza; Faizi, Mehrdad; Abdollahnejad, Fatemeh; Naghdibadi, Hassanali; Najafi, Foroogh; Razmi, Ali

doi:10.3109/13880209.2016.1148175

Cited by 13 publications

(11 citation statements)

References 23 publications

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“…Better effects of the volatile oil have been identified than the reference, with possible mechanisms influencing GABA-ergic neurotransmission. Anxiolytic effects have also been reported after treatment with the entire complex of biologically active substances of the plant (76). Myrtus communis essential oil also prolongs barbiturate-induced sleep in mice (77).…”

Section: Myrtenal-containing Medicinal Plants and The Biological Actimentioning

confidence: 99%

“…Our studies on mice also found a significant anxiolytic effect of myrtenal (Marble burying test) comparable to that of diazepam as a reference (103). According to some authors, the whole complex of biologically active substances (76), like the hydroxyl derivative myrtenol (essential oil component), have anxiolytic properties (102) with possible mechanism of response to GABA neurotransmission.…”

Section: Biological Effects Of Bicyclic Monoterpenoid Myrtenal (Alone)mentioning

confidence: 99%

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A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils

Dragomanova

Tancheva

Georgieva

2018

Scripta Scientifica Pharmaceutica

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INTRODUCTION: Myrtenal, a component of many plants' essential oils, is a bicyclic monoterpenoid. Numerous effects of myrtenal in experimental animals have been found-bronchodilatory, anti-inflammatory, anti-aggregative and antihemolytic (in vitro), and antibacterial. Its other activities have been studiedantioxidant, antitumor, antihyperglycemic, vasodilating, heart rate reducing and hypotensive. Myrtenal is relatively little studied in the field of neuroscience. AIM: The aim of this article is to summarize the available information on the established biological activity of the monoterpenoid myrtenal. MATERIALS AND METHODS: Scientific databases such as PubMed, ResearchGate, HMDB and others have been used to provide information on the published results of properties and activities of the test substance (myrtenal) over a period of 15 years (2003-2018). RESULTS: Our research confirmed the available data for its central nervous system (CNS) activity-anxiolytic and potentiating the effects of the hypnotic drugs, as well as the antioxidant properties. We have evaluated the neuromodulatory activity of M in brain tissue manifested in elevated levels of major neurotransmitters in healthy rodents and those with neurodegenerative changes accompanied by improvement in the animals' memory. CONCLUSION: Significant protective effects of myrtenal on neurodegenerative processes were established. Probably they are related to its complex mechanisms, including neuromodulatory and antioxidant properties.

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Section: Myrtenal-containing Medicinal Plants and The Biological Actimentioning

confidence: 99%

Section: Biological Effects Of Bicyclic Monoterpenoid Myrtenal (Alone)mentioning

confidence: 99%

A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils

Dragomanova

Tancheva

Georgieva

2018

Scripta Scientifica Pharmaceutica

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“…Different parts (berries, branches, and leaves) of M. communis (myrtle) have been used in folk medicine for treating diarrhoea, peptic ulcers, haemorrhoids, inflammation, uterine bleeding, headache, palpitation, leucorrhoea, urethritis, epistaxis, conjunctivitis, excessive perspiration, and pulmonary and skin diseases [ 4 , 7 ]. Only few studies have reported a sedative effect of myrtle, as a anxiolytic and muscle relaxant without anticonvulsivant activity [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Myrtus communis L. and Myrtus nivellei Batt. & Trab. Extracts: A Brief Review

2018

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Myrtus communis L. (myrtle) and Myrtus nivellei Batt. & Trab. (Saharan myrtle) have been used in folk medicine for alleviating some ailments. M. communis is largely distributed in the Mediterranean Basin, whereas M. nivellei is confined in specific zones of the central Saharan mountains. The chemical composition and antioxidant activity of berry and leaf extracts isolated from myrtle are deeply documented, whereas those isolated from Saharan myrtle extracts are less studied. In both species, the major groups of constituents include gallic acid derivatives, flavonols, flavonol derivatives, and hydroxybenzoic acids. In coloured berries, anthocyanins are also present. In M. nivellei extracts are reported for some compounds not described in M. communis so far: 2-hydroxy-1,8-cineole-β-d-glucopyranoside, 2-hydroxy-1,8-cineole 2-O-α-l-arabinofuranosyl (1→6)-β-d-glucopyranoside, rugosin A, and rugosin B. Berries and leaves extracts of both species had antioxidant activity. Comparative studies of the antioxidant activity between leaf and berry myrtle extracts revealed that leaf extracts are best antioxidants, which can be assigned to the galloyl derivatives, flavonols, and flavonols derivatives, although the ratio of these groups of compounds might also have an important role in the antioxidant activity. The anthocyanins present in myrtle berries seem to possess weak antioxidant activity. The antioxidant activity of sample extracts depended on various factors: harvesting time, storage, extraction solvent, extraction type, and plant part used, among other factors. Leaf extracts of myrtle revealed to possess anti-inflammatory activity in several models used. This property has been attributed either to the flavonoids and/or hydrolysable tannins, nevertheless nonprenylated acylphloroglucinols (e.g., myrtucommulone and semimyrtucommulone) have also revealed a remarkable role in that activity. The biological activities of myrtle extracts found so far may direct its use towards for stabilizing complex lipid systems, as prebiotic in food formulations, and as novel therapeutic for the management of inflammation.

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“…Previous studies have reported that administration of extracts from natural herbal medicine, which exhibited hypnotic effect, altered total sleep time and NREM rather than REM sleep (Abdollahnejad et al ., 2016; Hajiaghaee et al ., 2016). In accordance with these studies, the present research showed that SF and matrine at a dose of 800 mg/kg and 30 mg/kg, respectively, reduced wake time considerably and SF (800 mg/kg) promoted a significant shift toward NREM sleep.…”

Section: Discussionmentioning

confidence: 99%

Sedative Effect ofSophora flavescensand Matrine

Lee

Jang

et al. 2017

Biomolecules & Therapeutics

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The present study investigated the sedative effects of Sophora flavescens (SF) and its bioactive compound, matrine through performing locomotor activity test and the electroencephalography (EEG) analysis in the rat. The underlying neural mechanism of their beneficial effects was determined by assessing c-Fos immunoreactivity and serotonin (5-HT) in the brain utilizing immunohistochemical method and enzyme-linked immunosorbent assay. The results showed that SF and matrine administration had an effect on normalization of caffeine-induced hyperactivity and promoting a shift toward non-rapid eye movement (NREM) sleep. c-Fos-immunoreactivity and 5-HT level in the ventrolateral preoptic nucleus (VLPO), a sleep promoting region, were increased in the both SF and matrine-injected groups. In conclusion, SF and its bioactive compound, matrine alleviated caffeine-induced hyperactivity and promoted NREM sleep by activating VLPO neurons and modulating serotonergic transmission. It is suggested that SF might be a useful natural alternatives for hypnotic medicine.

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Hydroalcoholic extract ofMyrtus communiscan alter anxiety and sleep parameters: a behavioural and EEG sleep pattern study in mice and rats

Cited by 13 publications

References 23 publications

A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils

A review: Biological activity of myrtenal and some myrtenal-containing medicinal plant essential oils

Antioxidant Activity of Myrtus communis L. and Myrtus nivellei Batt. & Trab. Extracts: A Brief Review

Sedative Effect ofSophora flavescensand Matrine

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