Hydroalcoholic Extracts of Eclipta Alba as a Reversal Agent in Boric Acid Induced Male Reproductive Toxicity

Nair, Pooja; Vora, Nidhi; Purandhar, Kaveri; Kamle, Vishal; Seshadri, Sriram

doi:10.2478/v10049-012-0002-5

Cited by 3 publications

(5 citation statements)

References 33 publications

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“…The current findings were somewhat similar to the findings of (38)(39)(40)(41), whereas all previous authors recorded a significant reduction in the hematological parameters in mice, rats, and fish, respectively after boric acid administration. The current results were in contrast with the findings of (42).…”

Section: Discussionsupporting

confidence: 91%

“…While there were non-significant changes in all previous variables of group 2. The previous findings were in contrast with the findings of (39).…”

Section: Discussioncontrasting

confidence: 79%

“…The current findings may due to that the high doses of boron inhibit the hemopoiesis and exhibit obvious toxicity activity in the blood or perhaps it is due to the red blood cell degradation and loss of its formation process which was approved by reducing MCHC measures (39).…”

Section: Discussionmentioning

confidence: 93%

“…The rise in serum enzymes in the current study suggests a disruption in the function of the liver cells and their enzymes. This impaired liver function caused its enzymes to be released into the blood system (39).…”

Section: Discussionmentioning

confidence: 99%

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Effect of boron on some organs of pregnant BALB/c mice

Salah¹

2021

IJVS

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Current research had been conducted to assess the impact of boric acid (boron) on the different tissues of the fetal and maternal bodies of pregnant mice Mus musculus and its influence on the maternal plasma biochemistry, hematology, in addition to the fetal and maternal bodies weight, moreover the weight of a certain motherly tissues included liver, kidney, lung, brain and spleen. The pregnant mice were administered orally with boric acid at the concentrations of 50 and 100 mg/kg during pregnancy. The observations at a concentration of 50 mg / kg demonstrated several histopathological patterns in different mothers and fetal body parts. The lesions were increased at the dose of 100 mg / kg. Moreover, boron caused weight decrease in the maternal body weight, fetuses, and liver, but it caused an increase in weight of the kidney at the concentration 100 mg/ kg. The biochemical assessment of the maternal serum showed a high rise in the level of liver enzymes, blood urea, creatinine, total protein, total bilirubin, glucose, cholesterol, triglycerides, HDL, and LDL at the concentration 100mg mg/kg. Furthermore, there was a meaningful change in the blood hematology at the concentration 100mg/kg. In conclusion, the exposure of pregnant mice to high concentrations of boric acid can alter the structure, the function of maternal and embryos organs by inducing oxidative stress, which in turn resulting in the accumulation of toxins in the blood that cause different effects during the exposure period.

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Section: Discussionsupporting

confidence: 91%

“…While there were non-significant changes in all previous variables of group 2. The previous findings were in contrast with the findings of (39).…”

Section: Discussioncontrasting

confidence: 79%

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Effect of boron on some organs of pregnant BALB/c mice

Salah¹

2021

IJVS

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“…Significant reversal comparable to the control groups was observed in oxidative stress in the vital tissues. The fertility of the rats was found to be restored 33 .…”

Section: Anti-cancer Potentialmentioning

confidence: 98%

Untitled

2019

IJPSR

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Though conventional medicines are slow in action, they represent safety in contrast to the synthetics that are regarded as somewhat unsafe to human and environment. The uses of many traditional herbs in the treatment of many diseases, which are usually free from side effects, are economical and also easily accessible to humans. Plants have formed the basis of sophisticated traditional medicine systems that have been in existence for hundreds of years and continue to provide mankind with new remedies. The use of synthetic chemical compounds has led to a decline in the use of plants in contemporary medicine. However, synthetic medicine can cause side effects, and as a result, people are more constructive to use natural compounds obtained from plants. Eclipta alba (L.) is a herbaceous plant which has been employed as traditional medicine especially in tropical and subtropical regions. E. alba is a widely applied traditional medicine and functional food, has been extensively explored for its bioactivities. The plant contains a broad array of active principles which includes coumestans, alkaloids, flavonoids, glycosides, polyacetylenes, and triterpenoids. The leaves contain stigmasterol, a-terthienylmethanol, wedelolactone, demethylwedelolactone, and demethylwedelolactone-7-glucoside. Some of the important pharmacological activities are antihepatotoxic, analgesic, antioxidant, antibacterial, antidiabetic, etc. This review article describes the phytochemical and pharmacological properties of Eclipta alba.

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