Hydroalcoholic extracts of Vellozia squamata: study of its nanoemulsions for pharmaceutical or cosmetic applications

Quintão, Frederico Jehár Oliveira; Tavares, Renata Spagolla Napoleão; Filho, Sidney Augusto Vieira; Souza, Gustavo Henrique Bianco de; Santos, Orlando David Henrique dos

doi:10.1590/s0102-695x2013005000001

Cited by 44 publications

(32 citation statements)

References 21 publications

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“…The water phase was heated to the same temperature and poured into the oil phase with a constant agitation speed of 600 rpm using a mechanical stirrer (model 713D; Fisaton, Perdizes, São Paulo, Brazil) until completely cool (25 °C, 30 min) . Macroscopic and microscopic analysis was performed after 24 hours of nanoemulsion preparation to observe organoleptic characteristics and homogeneity …”

Section: Methodsmentioning

confidence: 99%

Seasonality study of essential oil from leaves of Cymbopogon densiflorus and nanoemulsion development with antioxidant activity

Seibert

Rodrigues

Carneiro

et al. 2018

Flavour & Fragrance J

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The development of formulations that maintain the biological and physical chemistry properties of essential oils is an important choice when they are used as an active ingredient. This study aimed to characterize the essential oil from leaves of Cymbopogon densiflorus and evaluate the antioxidant activity of the oil, and to produce a nanoemulsion formulation containing it. The essential oil was obtained by hydrodistillation, and seasonality was analysed every 2 months by gas chromatography–mass spectrometry, showing that more than 90% of the composition was maintained for the whole period and that the major compounds were trans‐p‐menta‐2,8‐dien‐1‐ol, cis‐p‐menta‐2,8‐dien‐1‐ol, trans‐p‐menta‐1(7),8‐dien‐2‐ol, cis‐piperitol, and cis‐p‐menta‐1(7),8‐dien‐2‐ol. Stable nanoemulsions were prepared by phase inversion method encapsulating the essential oil. The antioxidant activity was evaluated by 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical scavenging and 2,2′‐azino‐bis(3‐ethylbenzothiazoline‐6‐sulphonic acid (ABTS) methods. In the first test, free and nanoemulsified essential oil showed half‐maximal inhibitory concentration (IC50) values equivalent to 14.689 and 3.692 mg mL−1, respectively. In the second test, these values were 0.567 and 0.43 mg mL−1. The development of nanoemulsion‐based essential oil from leaves of C. densiflorus was viable, and the formulated oil was able to reproduce the antioxidant activity at a concentration four times lower than that of the pure essential oil.

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Section: Methodsmentioning

confidence: 99%

Seasonality study of essential oil from leaves of Cymbopogon densiflorus and nanoemulsion development with antioxidant activity

Seibert

Rodrigues

Carneiro

et al. 2018

Flavour & Fragrance J

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“…Antioxidant activity of the prepared suspension and of their different constituents was determined using DPPH scavenging radical method, according to the protocol described by (Molyneux, ; Quintão, Tavares, Vieira‐Filho, Souza, & Santos, ) with some modifications. Briefly, DPPH solution at 0.004 g per 100 ml of methanol was prepared.…”

Section: Methodsmentioning

confidence: 99%

Formulation of stable microcapsules suspensions contentSalvia officinalisextract for its antioxidant activity preservation

Bachir

Zafour

Medjkane

2017

J Food Process Preserv

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The stabilization of microparticles suspensions is always assured by macromolecules that allow the increasing of dispersing phase viscosity and maintaining the microparticles dispersibility. In this work, the effect of xanthan gum, tragacanth, and sodium alginate on the stability of gelatin–pectin microcapsules suspensions containing sage polyphenols as an active substance was investigated. After polyphenols extraction from Salvia officinalis, their characterization by HPLC‐UV/DAD and their microencapsulation by complex coacervation technique using gelatin and pectin. Three different suspensions of microcapsules were prepared using different polymeric dispersant agents. The suspensions were characterized by laser for particle size, zetametry, viscosimetry, and evaluation of their antioxidant activities was carried out by the DPPH scavenging radical method. Stability study of prepared suspensions was undertaken during 90 days, the results obtained showed that sodium alginate and tragacanth had a better stabilizing effect compared with xanthan gum. After formulation of sage extract, its antioxidant activity increases and its half‐life time increases from 12.75 ± 1.95 days (R2 = .93) to 258.64 ± 21.99 days (R2 = 0.98). Practical applications Microencapsulation yield of sage extract in gelatin–pectin is 73.54 ± 2.04%. About 0.5% of sodium alginate permits the stabilization of microcapsules suspension. Sodium alginate and tragacanth had a better stabilizing effect compared with xanthan. After formulation, antioxidant activity of sage extract increases. After formulation, half‐life time of sage extract increases from 12.75 ± 1.95 to 258.64 ± 21.99 days.

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“…[15][16][17] Considering the advantages of nanoemulsions, many studies on incorporation of herbal drugs into these systems have been carried. 11,[18][19][20][21] Rapanea ferruginea (Ruiz & Pav) Mez (synonymy Myrsine coriacea) is a tree popularly known in Brazil as capororoca. Its leaves and stem barks are prepared as tea and are recommended, in popular use, to treat diseases of the urinary tract, as well as itching, rashes, hives, eczema, rheumatism, and diseases of the liver.…”

Section: Dal Mas Et Almentioning

confidence: 99%

Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of <em>Rapanea ferruginea</em>

Mas

Zermiani

Thiesen

et al. 2016

IJN

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The aim of this study was to develop nanoemulsion containing soft extract of stem bark of Rapanea ferruginea to improve the topical delivery and anti-inflammatory activity. The extract of R. ferruginea stem bark was incorporated into the oily phase of the nanoemulsion by the method of phase inversion at low energy. The developed nanoemulsion had an average droplet size of 47.88±8.20 nm and a polydispersibility index of 0.228. Uniformity of size, spherical shape of droplet, and absence of clusters were confirmed by transmission electronic microscopy. The zeta potential was −34.7±1.15 mV. The nanoemulsion showed a moderate degree of skin irritation in the agarose overlay assay in vitro. The content of the extract markers, myrsinoic acids A and B, was 54.10±0.08 and 53.03 μg/g in the formulation, respectively. The formulation demonstrated pseudoplastic and thixotropic rheological behavior. In vitro release of chemical markers was controlled by diffusion mechanism. An extract-loaded nanoemulsion showed a topical anti-inflammatory activity in a croton oil-induced edema ear model, with a decrease in tumor necrosis factor release and myeloperoxidase activity. The nanoemulsion was 160% more efficient than the conventional cream containing 0.13% of the extract. The nanoemulsion showed suitable properties as a carrier for topical use of R. ferruginea extract and the approach for improving the topical anti-inflammatory activity.

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Hydroalcoholic extracts of Vellozia squamata: study of its nanoemulsions for pharmaceutical or cosmetic applications

Cited by 44 publications

References 21 publications

Seasonality study of essential oil from leaves of Cymbopogon densiflorus and nanoemulsion development with antioxidant activity

Seasonality study of essential oil from leaves of Cymbopogon densiflorus and nanoemulsion development with antioxidant activity

Formulation of stable microcapsules suspensions contentSalvia officinalisextract for its antioxidant activity preservation

Nanoemulsion as a carrier to improve the topical anti-inflammatory activity of stem bark extract of <em>Rapanea ferruginea</em>

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