Hydroalkoxylation Catalyzed by a Gold(I) Complex Encapsulated in a Supramolecular Host

Abstract

Gold(I)-phosphine complexes are readily encapsulated by a tetrahedral supramolecular host (Ga(4)L(6)). We have investigated the catalytic activity of the resulting complexes for the intramolecular hydroalkoxylation of allenes. The catalytic activity of Me(3)PAuBr was increased 8-fold by encapsulation, as determined by initial rate kinetics, and we observed up to 67 catalytic turnovers by Me(3)PAu(+) encapsulated in Ga(4)L(6).

Self-assembled metal–organic polyhedra: An overview of various applications

“…Encapsulation of organometallic complexes in an anionic tetrahedral cage arose a new direction to the reactivity of a particular reaction [130]. For example, encapsulation of (Me 3 P)CpRu(NCMe) 2 + complex in tetrahedral cage 1 directs the isomerization of allyl alcohol into the corresponding aldehyde.…”

Synthesis of Saturated Heterocycles via Metal-Catalyzed Alkene Hydroamination or Hydroalkoxylation Reactions

“…Nonetheless, this complex has proven to be a useful catalyst in other alkene hydrofunctionalizations reactions. A gold complex encapsulated in a supramolecular host has also shown catalytic activity in hydroalkoxylation reactions of allenyl alcohols [129].…”

A Stimuli‐Responsive Rotaxane–Gold Catalyst: Regulation of Activity and Diastereoselectivity

“…[11] Herein, we report ar otaxane-gold catalyst [12,13] in which the mechanical bond influences both diastereoselectivity and catalytic activity,and we demonstrate stimuli-responsive control of both of these important reaction parameters.…”