2015
DOI: 10.1111/wrr.12349
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Hydrocellular foam dressing increases the leptin level in wound fluid

Abstract: Hydrocellular foam dressing (HCF) absorbs excessive wound fluid, which contains various cytokines and growth factors, and ensures a moist environment to promote wound healing. However, the molecular mechanisms underlying the wound fluid component changes induced by HCF are poorly understood. In the present study, we examined the effect of HCF on wound healing and the associated regulatory mechanisms in relation to variations in cytokine levels in the wound fluid. We created full-thickness wounds on the dorsola… Show more

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Cited by 10 publications
(6 citation statements)
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“…[2][3][4] Local and systemic factors can contribute to the development of different types of chronic wounds including venous, pressure, arterial, or diabetic ulcers. 2,5 On a molecular level, chronic wound fluid is comprised of cytokines, chemokines, growth factors, electrolytes, and proteolytic enzymes, [6][7][8] which are imbalanced and delay the normal wound-healing cascade.…”
Section: Introductionmentioning
confidence: 99%
“…[2][3][4] Local and systemic factors can contribute to the development of different types of chronic wounds including venous, pressure, arterial, or diabetic ulcers. 2,5 On a molecular level, chronic wound fluid is comprised of cytokines, chemokines, growth factors, electrolytes, and proteolytic enzymes, [6][7][8] which are imbalanced and delay the normal wound-healing cascade.…”
Section: Introductionmentioning
confidence: 99%
“…Chronic wound fluid is comprised of cytokines, chemokines, growth factors, electrolytes and proteolytic enzymes [30,31,32]. Proteolytic enzymes, in particular matrix metalloproteases (MMP) and serine protease human neutrophil elastase (HNE), are responsible for proteolytic degradation of growth factors [19] and extracellular matrix (ECM) proteins.…”
Section: Introductionmentioning
confidence: 99%
“…A leptin surge induces the onset of puberty and the expression of reproductive and metabolic neuropeptides in the hypothalamus . Recently, leptin was recognized as a prospective bioactive factor for tissue restoration in many aspects, such as promoting the regeneration of vessels and myocardial, skin, mucosal, and retinal cells. More importantly, leptin is substantially significant for the growth and development of the skeletal system. The leptin receptor is regarded as a marker of mesenchymal stromal cells, which are important for bone and cartilage restoration, in adult bone marrow .…”
Section: Discussionmentioning
confidence: 99%