1993
DOI: 10.1161/01.hyp.21.5.638
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Hydrochlorothiazide improves ventricular compliance and thus performance without reducing hypertrophy in renal artery stenosis in rats.

Abstract: The effect of hydrochlorothiazide (1 mg/kg per day) on left ventricular (LV) mass and systolic and diastolic function was investigated in two-kidney, one clip (2K1C) renovascular hypertensive rats. Hydrochlorothiazide was administered from 8 weeks, and LV mass and function were measured at 16 weeks after surgery to induce hypertension. Cardiac performance was determined from cardiac output, stroke volume (per 100 g of body weight), and stroke work (per gram of LV weight) versus LV end-diastolic pressure (LVEDP… Show more

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Cited by 8 publications
(5 citation statements)
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“…4,16,17 None of the rats died during ISO or vehicle administration, and 1 untreated SHR died of an indeterminate cause at 16 months of age (not included in the above sample numbers). Noninvasive systolic blood pressures (SBPs) were measured as previously described 18 at regular periods throughout the study. Chronic ISO administration may produce an enhanced LV filling volume through ␤ 2 -AR-mediated vasodilation and/or sympathetic effects on the kidney and, consequently, mediate LV remodeling through indirect mechanisms (preload-induced changes).…”
Section: Experimental Groupsmentioning
confidence: 99%
“…4,16,17 None of the rats died during ISO or vehicle administration, and 1 untreated SHR died of an indeterminate cause at 16 months of age (not included in the above sample numbers). Noninvasive systolic blood pressures (SBPs) were measured as previously described 18 at regular periods throughout the study. Chronic ISO administration may produce an enhanced LV filling volume through ␤ 2 -AR-mediated vasodilation and/or sympathetic effects on the kidney and, consequently, mediate LV remodeling through indirect mechanisms (preload-induced changes).…”
Section: Experimental Groupsmentioning
confidence: 99%
“…Of those rats that did not survive the study period and were not included in the sample numbers given, 8 untreated SHR died at between 23 and 26 months of age (2 of a respiratory pathogen and 6 with signs of heart failure), 2 WKY (1 untreated and 1 hydralazine treated) died of soft tissue tumors at variable time periods, and 2 untreated WKY died of a respiratory pathogen at variable time periods; no hydralazinetreated SHR died. Systolic blood pressure was measured as previously described 13 at regular periods throughout the study.…”
Section: Experimental Groupsmentioning
confidence: 99%
“…The surgery, instrumentation, experimental techniques, and calculations used in our current study have previously been described and validated. [12][13][14] LV end diastolic (LVED) radius was determined from the equation…”
Section: Geometry and Dimensionsmentioning
confidence: 99%
“…As the wall thickens by parallel replication of sarcomeres (figure 1.1), concentric hypertrophy may reduce cardiac filling because of a reduced radius (Grossman et al 1975, & Norton et al 1993. Hence the diastolic pressure-volume curve would be left shifted compared to normal, and the volume at a pressure of 0 mm Hg (V 0 ) would be decreased (figure 1.1).…”
Section: Cardiac Hypertrophymentioning
confidence: 99%