Hydrocodone/Acetaminophen and Tramadol Chlorhydrate Combination Tablets for the Management of Chronic Cancer Pain: A Double-blind Comparative Trial

Abstract

There was no superior analgesic efficacy with the administration of hydrocodone/acetaminophen when compared to patients receiving tramadol in the relief of cancer pain. Tramadol produced more mild side effects than hydrocodone.

Further Validation of the BDI-II Among People With Chronic Pain Originating From Musculoskeletal Disorders

“…For example, opioid and nonopioid analgesic pain treatments are often associated with somatic side effects such as anorexia, dizziness, and weakness. 38 Consequently, it is not surprising that participants identified medication side effects as a cause of specific depressive symptoms, such as those associated with the somatic dimension. Functional limitation and dependence on others were identified more often within the cognitive and affective dimensions.…”

Pharmacological Management of Cancer-Related Pain

“…28 Pain did not respond to hydrocodone/acetaminophen administration in 29% of study patients. 28 Another multicenter, double-blind, randomized, parallel group study compared codeine/acetamino-phen phosphate with hydrocodone/acetaminophen for moderate to severe pain. 29 Study patients had chronic moderate to severe cancer pain (> 3 on a 10-cm visual analog scale and > 1 on a 4-point verbal intensity scale).…”

“…28 Analgesic responses increased by 15% with dose doubling. 28 Pain did not respond to hydrocodone/acetaminophen administration in 29% of study patients. 28 Another multicenter, double-blind, randomized, parallel group study compared codeine/acetamino-phen phosphate with hydrocodone/acetaminophen for moderate to severe pain.…”

“…A total of 62 study patients received hydrocodone/acetaminophen and 56 received tramadol. 28 Hydrocodone/acetaminophen decreased pain in 57% of participants at a starting dose of 25 mg/2500 mg/day (5 doses per day). 28 Analgesic responses increased by 15% with dose doubling.…”

“…28 Hydrocodone/acetaminophen decreased pain in 57% of participants at a starting dose of 25 mg/2500 mg/day (5 doses per day). 28 Analgesic responses increased by 15% with dose doubling. 28 Pain did not respond to hydrocodone/acetaminophen administration in 29% of study patients.…”