Hydrocortisone-Production Rates in Africans

Thijssen, J. H. H.; Waard, F. de; Wiersinga, A

doi:10.1016/s0140-6736(67)92779-1

Cited by 22 publications

(1 citation statement)

References 15 publications

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“…Cortisol production rates were determined by a modification of the method of Cope and Black (Thijssen et al, 1967). Plasma fluorogenic corticosteroids were measured fluorometrically (Mattingly, 1962).…”

Section: Introductionmentioning

confidence: 99%

Recovery of Adrenocortical Function during Long-term Treatment with Corticosteroids

Westerhof¹,

Ditmars²,

Kinderen³

et al. 1970

BMJ

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Section: Introductionmentioning

confidence: 99%

Recovery of Adrenocortical Function during Long-term Treatment with Corticosteroids

Westerhof¹,

Ditmars²,

Kinderen³

et al. 1970

BMJ

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Hormone Secretion in Alcohol-Induced Pseudo-Cushing's Syndrome

Lamberts¹

1979

JAMA

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We describe the clinical and biochemical characteristics of alcohol-induced pseudo-Cushing's syndrome in two patients with signs and symptoms of Cushing's syndrome and slight disturbances in liver function. An insufficient suppression of plasma cortisol to the overnight administration of 1 mg of dexamethasone was accompanied by an absent diurnal rhythm of plasma cortisol and an increased cortisol secretion rate. The plasma cortisol levels at 8 AM normalized during hospital admission (ie, alcohol withdrawal) at the same rate or parallel with the serum gamma-glutamyl transferase concentration. A normal increase of plasma cortisol, adrenocorticotropic hormone, and growth hormone in response to an insulin induced hypoglycemia was not compatible with the diagnosis Cushing's syndrome. However, the result of a differential diagnostic test with metyrapone was compatible with the presence of Cushing's disease. An erroneous diagnosis of Cushing's disease can be easily made in patients with alcohol-induced pseudo-Cushing's syndrome.

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The epidemiology of breast cancer; Review and prospects

Waard

1969

Intl Journal of Cancer

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In the epidemiology of a disease, which is multifactorial lo such an extent as we believe breast cancer to be, attention should be paid even to " In his review on the epidemiology of breast cancer, Lilienfeld (1963) made a plea for integrating laboratory investigations with epidemiological field studies. Six years later we are beginning to reach an era in which the epidemiologist turns to his friends in biochemistry (or they turn to him) in order to tackle this vast problem together. The task is vast indeed but not insoluble since we now have sufficient data on possible risk factors to undertake a number of prospective studies which will give us by, say, 1980, an insight into its aetiology, comparable to the knowledge which we have obtained over the past 20 years in coronary heart disease.The comparison with coronary heart disease is relevant in that laboratory studies in lipid metabolism have greatly helped us in understanding the interactions between environmental and " endogenous " factors, e.g. the effect of nutrition and exercise on blood cholesterol levels. In a similar way epidemiologists will have to venture into the field of endocrinology to advance their understanding of breast cancer. It will not be enough if they simply hand over a number of bottles of urine or some tubes with frozen plasma from cancer patients and controls to their biochemical colleagues. We shall have to learn more about the factors which might influence hormone patterns in normal women. Part of this knowledge has already been obtained by clinical endocrinologists, e.g. the effects of over-eating and starvation on adrenocortical hormone production and excretion; other aspects will arise through questions by epidemiologists.In the meantime, biochemists are introducing methods for the measurement of pituitary hormones in human body fluids. It will be of particular importance to develop a method for the estimation of human prolactin.What do we know? In human beings, as well as in other vertebrate species, possible aetiological factors in breast cancer development can be divided into four categories: 1) Hormonal factors; 2) Genetic factors; 3) Environmental factors;

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Hydrocortisone-Production Rates in Africans

Cited by 22 publications

References 15 publications

Recovery of Adrenocortical Function during Long-term Treatment with Corticosteroids

Recovery of Adrenocortical Function during Long-term Treatment with Corticosteroids

Hormone Secretion in Alcohol-Induced Pseudo-Cushing's Syndrome

The epidemiology of breast cancer; Review and prospects

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