Hydrocyanation of Non‐Activated Alkenes Without Handling HCN
Rafael Chinchilla,
Alejandro Baeza
Abstract:The hydrocyanation of alkenes can be considered a straightforward methodology that gives access to different functionalized organic chemistry entities. This is due to nitrile's high versatility, which can easily undergo further transformations. However, this process has traditionally employed hazardous hydrogen cyanide as the hydrocyanation agent. Therefore, in the last decades, different protocols have been developed to accomplish this key organic transformation without needing to handle HCN. In this review, … Show more
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