This review examined the viability of hydrodynamic cavitation as a pretreatment method to improve biodegradability and reduce toxicity in alcoholic vinasse. The growing interest in environmental impacts and the demand for sustainable solutions in the alcohol production industry have driven the search for efficient methods to treat vinasse, a complex and polluting by-product. The basic principles of hydrodynamic cavitation and its application in contaminant removal are explored in detail. Through a critical review of existing research, the efficiency of removal of organic load and recalcitrant contaminants, the influence of geometric parameters, the operational parameters of the process, and the challenges of applying hydrodynamic cavitation as pretreatment of alcoholic vinasse are analyzed. Despite its limitations, its potential as a solution to address pollution problems in alcohol production stands out. Ultimately, this review aims not only to collect and analyze the available information but also to encourage future research in this direction. Therefore, this review article is presented as an essential resource that guides future researchers and practitioners towards more sustainable and effective solutions, significantly contributing to environmental improvements in the industry.