Hydrodynamic control of droplets coalescence in microfluidic devices to fabricate two-dimensional anisotropic particles through boundary element method

Reactions and Polymerizations at the Liquid–Liquid Interface

“…The precise control over single droplets, a high throughput at kHz rates , with lab-on-chip devices, , and the generation of almost monodisperse droplets , (with coefficients of variation as low as 1.3%) represent the main advantages of droplet-based microfluidics. Furthermore, the versatility of structures that can be obtained, the generation of double , or multiple emulsions, − the synthesis of irregular particles, − core–shell structures, − Janus particles, , and liposomes , or polymersomes , have contributed to the popularization of microfluidic devices.…”

Stagnation point flows in analytical chemistry and life sciences

“…123,[212][213][214][215][216] Using this device, cell deformability measurements were achieved by harnessing cell concentrations by viscoelastic micro ows of polymer solution, 204 CNT breakup was attained by simply increasing ow rates, 207 drop deformation was examined as a function of connement, 209 and DNA compaction was triggered by introducing Na + and polyethylene glycol (PEG) to the DNA molecules held at the stagnation point. 210 Of the aforementioned applications, one particularly interesting use of the cross-slot generated stagnation is for the precise control of droplet coalescence, 217 while generating multiple emulsions; a concept that hold a lot of promise in pharmaceutics. 218 Wang et al suggested that the simple crossslot generated ow eld is inadequate to accurately control the coalescence of multiple droplets; hence they adapted the geometry of Fig.…”

“…4c(iv) and developed numerical methodologies to investigate the rheology of multiple emulsions. 217,219,220 In their work, they numerically demonstrated the use of cross-slot ow control techniques to precisely engineer the adhesion of single drops to form bigger dropseven to the point of dictating the angle of contact. 217 By adjusting the extensional and compressional ow towards the stagnation point, they were able to achieve location specic consecutive coalescence of multiple droplets.…”

Numerical analysis of mixing performance in sinusoidal microchannels based on particle motion in droplets

“…Additionally, droplet motion over obstacles and spacing of droplets and generation algorithms were studied by different research groups to understand physics of droplet motion in the computational manner (Lee and Son 2013;Maddala and Rengaswamy 2014). Previous computational fluid dynamics (CFD) simulations were based on either lattice Boltzmann method (Wu et al 2008), boundary element method (Wanga et al 2014), or finite elements with level set method (Chung et al 2009;Yan et al 2012;Bashir et al 2011). Finite element method combined with level set method was used more frequently among the other numerical approaches.…”