Abstract. We study the emergent dynamics for the hydrodynamic Cucker-Smale system arising in the modeling of flocking dynamics in interacting many-body systems. Specifically, the initial value problem with a moving domain is considered to investigate the global existence and time-asymptotic behavior of classical solutions, provided that the initial mass density has bounded support and the initial data are in an appropriate Sobolev space. In order to show the emergent behavior of flocking, we make use of an appropriate Lyapunov functional that measures the total fluctuation in the velocity relative to the mean velocity. In our analysis, we present the local well-posedness of the smooth solutions via Lagrangian coordinates, and we extend to the global-in-time solutions by establishing the uniform flocking estimates. 1. Introduction. The purpose of this paper is to continue our study [14] on the large-time dynamics of the hydrodynamic Cucker-Smale (C-S) model that arises from the macroscopic description of flocking modeling. Consider an ensemble of many C-S flocking particles that occupy a finite region in R d . When the number of particles is sufficiently large and the system is in a close-to-flocking state, the dynamics of the ensemble can be described effectively by a fluid-type model, i.e., the hydrodynamic C-S model with a moving vacuum boundary. Let ρ and u be the local mass density and bulk velocity, respectively, of the ensemble, the support of which is denoted by a time-varying set Ω(t) := {x ∈ R d | ρ(x, t) = 0} for a given initially bounded open set Ω := Ω(0). In this case, the macroscopic dynamics of the ensemble is governed by the initial value problem of the hydrodynamic C-S system: