A computational fluid dynamics study of the horizontal oil–water flow was performed using the Eulerian–Eulerian and mixture multiphase models in conjunction with the realizable k–ε turbulence model for the characterization of flow patterns. The experimental tests were carried out using water and mineral oil with a density of 880 kg/m3 and a viscosity of 180 cP, varying the superficial velocities of both fluids in ranges of 0.1–1.2 m/s and 0.1–0.5 m/s, respectively. The numerical model was defined under the same initial and boundary conditions as in the experiment. Moreover, the model is defined such that entering the fluids in a mixed state, the stratified pattern could form adequately with the two multiphase models. Although the Eulerian–Eulerian model, together with the geometric reconstruction scheme, allowed us to visualize the three-dimensional dispersed patterns in a very similar way to the experimental results, the mixture model did not exhibit such similarity, especially in the oil-in-water dispersions. Additionally, the Eulerian–Eulerian model was able to predict the experimental holdup values with an average error of 15.2%.