Hydroethanolic extract of Baccharis trimera ameliorates alcoholic fatty liver disease in mice

Lívero, Francislaine Aparecida dos Reis; Martins, Gracianny Gomes; Telles, José Ederaldo Queiroz; Beltrame, Olair Carlos; Biscaia, Stellee Marcela Petris; Franco, Célia Regina C.; Elferink, Ronald P.J. Oude; Acco, Alexandra

doi:10.1016/j.cbi.2016.10.003

Cited by 32 publications

(23 citation statements)

References 56 publications

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“…In addition, B. trimera ameliorates carbonylated protein and TBARS levels. Improvement in lipid peroxidation was also found when mice received hydroethanolic extract of B. trimera [13]. These results (summarized in Figure 4) suggest that although carqueja does not act on the antioxidant enzymes, it modulates their expression and decreases the oxidative damage promoted by diabetes.…”

Section: Discussionmentioning

confidence: 84%

“…B. trimera did not promote change in lipid profile or renal function; however, the extract was able to decreased AST activity, showing improvement in liver profile. The hydroethanolic extract of B. trimera ameliorates a lipid profile and liver function in alcoholic fatty liver disease [13]. This may suggest that the mechanism of action of B. trimera depends on the model of disease studied.…”

Section: Discussionmentioning

confidence: 99%

“…Baccharis trimera (Less.) D.C., popularly known as “carqueja,” is one of the most commonly used medicinal plant and already had several proven biological effects such as hypoglycemic [12], hepatoprotective [13, 14] and antioxidant [15–17]. Other species of the genus Baccharis may present marked toxicity [18, 19], raising concerns about the use of plants from this genus.…”

Section: Introductionmentioning

confidence: 99%

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Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes

Kaut

Rabêlo

Araújo

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Diabetes mellitus is a metabolic disorder that causes severe complications due to the increased oxidative stress induced by disease. Many plants are popularly used in the treatment of diabetes, e.g., Baccharis trimera (carqueja). The aim of this study was to explore the potential application of the B. trimera hydroethanolic extract in preventing redox stress induced by diabetes and its hypoglycemic properties. Experiments were conducted with 48 female rats, divided into 6 groups, named C (control), C600 (control + extract 600 mg/kg), C1200 (control + extract 1200 mg/kg), D (diabetic), D600 (diabetic + 600 mg/kg), and D1200 (diabetic + 1200 mg/kg). Type 1 diabetes was induced with alloxan, and the animals presented hyperglycemia and reduction in insulin and body weight. After seven days of experimentation, the nontreated diabetic group showed changes in biochemical parameters (urea, triacylglycerol, alanine aminotransferase, and aspartate aminotransferase) and increased carbonyl protein levels. Regarding the antioxidant enzymes, an increase in superoxide dismutase activity was observed but in comparison a decrease in catalase and glutathione peroxidase activity was noted which suggests that diabetic rats suffered redox stress. In addition, the mRNA of superoxide dismutase, catalase, and glutathione peroxidase enzymes were altered. Treatment of diabetic rats with B. trimera extract resulted in an improved glycemic profile and liver function, decreased oxidative damage, and altered the expression of mRNA of the antioxidants enzymes. These results together suggest that B. trimera hydroethanolic extract has a protective effect against diabetes.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes

Kaut

Rabêlo

Araújo

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…This is further supported by the reduced oxidative stress (MDA) and improved liver function (AST and ALT) in the resveratrol group. There are divergent views on the significance of the absolute values of antioxidant enzyme activities as a reflection of their effects [ 32 , 33 ], in which case SOD/CAT + GPx ratio has been used [ 34 , 35 ]. The data again suggested that resveratrol modulated antioxidant enzymes, which may have been the basis for the improved attenuation of oxidative stress and ultimately ALD.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress

Hou

Song

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to investigate the hepatoprotective effects of resveratrol in alcoholic liver disease (ALD). Alcohol was administered to healthy female rats starting from 6% (v/v) and gradually increased to 20% (v/v) by the fifth week. After 16 weeks of intervention, liver enzymes (aspartate aminotransferase [AST] and alanine aminotransferase [ALT]) were analyzed using a chemistry analyzer, while hepatic antioxidant enzymes, oxidative stress markers, and caspase 3 activity were assessed using ELISA kits. Furthermore, hepatic CYP2E1 protein levels and mRNA levels of antioxidant and inflammation-related genes were determined using western blotting and RT-PCR, respectively. The results showed that resveratrol significantly attenuated alcohol-induced elevation of liver enzymes and improved hepatic antioxidant enzymes. Resveratrol also attenuated alcohol-induced CYP2E1 increase, oxidative stress, and apoptosis (caspase 3 activity). Moreover, genes associated with oxidative stress and inflammation were regulated by resveratrol supplementation. Taken together, the results suggested that resveratrol alleviated ALD through regulation of oxidative stress, apoptosis, and inflammation, which was mediated at the transcriptional level. The data suggests that resveratrol is a promising natural therapeutic agent against chronic ALD.

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“…In Brazil, it is popularly known a carqueja, carqueja-amarga, carqueja-do-mato, vassoura [7] , [8] . Studies published about B. trimera describe analgesic [9] , [10] , muscle relaxant effects [11] , antidiabetic [12] , antioxidant [13] , anti-inflammatory [14] , [15] anthelmintic activity [16] and hepatotoxicity [17] . Silva et al.…”

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confidence: 99%

Acute toxicity and antimicrobial activity of leaf tincture Baccharis trimera (Less)

et al. 2018

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BackgroundThe present study aimed to evaluate the possible acute oral toxicity of Baccharistrimera leaf dye as well as its antimicrobial activity.MethodOrganization for Economic co-operation and development (OECD) 423 was used to assess acute oral toxicity and as per protocol a dose of 2000 mg/kg of tincture was administered to Wistar rats, male and female, and observed for 14 days. Biochemical and hematological analyzes were performed with sample collected of rat. The dye was evaluated for antimicrobial activity by agar diffusion and microdilution methods, which allow to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) and antibiofilm potential.ResultsThe results showed that there was no loss of animals and no significant changes in hematological and biochemical parameters after oral administration of 2000 mg/kg of tincture and was considered safe by the OECD, classified as category 5. The dyeing also showed an important antimicrobial activity against gram positive and gram negative bacteria also significantly decreased the microbial biofilm.ConclusionThe tincture of B.trimera leaf when given orally once can be considered safe and has a relevant antimicrobial potential that should be elucidated in subsequent research.

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Hydroethanolic extract of Baccharis trimera ameliorates alcoholic fatty liver disease in mice

Cited by 32 publications

References 56 publications

Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes

Baccharis trimera (Carqueja) Improves Metabolic and Redox Status in an Experimental Model of Type 1 Diabetes

Resveratrol Ameliorates Experimental Alcoholic Liver Disease by Modulating Oxidative Stress

Acute toxicity and antimicrobial activity of leaf tincture Baccharis trimera (Less)

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