Hydrogel adhesive formed <i>via</i> multiple chemical interactions: from persistent wet adhesion to rapid hemostasis

Min, Liang; Wei, Dandan; Yao, Zhangyu; Ren, Pengfei; Dai, Jidong; Xu, Lihua; Zhang, Tianzhu; Zhang, Qianli

doi:10.1039/d1bm01848e

Cited by 20 publications

(11 citation statements)

References 53 publications

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“…In addition to self-healing properties, the abundant adhesion groups in the hydrogel network formed multiple interfacial bonds with the tissue surface, including electrostatic interactions and cation−π interactions in addition to hydrogen bond, resulting in strong adhesion (Figure H). − To compare the variation of the adhesion strength of hydrogel sensors under physiological conditions upon exposure to various media, we tested the adhesion strength of GUT-PP hydrogels exposed to water, blood, grease, and air conditions by a lap shear test. The results in Figure S6 showed that the adhesion strength of GUT-PP hydrogels exposed to water and blood (∼10 kPa) decreased compared with that in air (∼16 kPa), due to the formation of a hydrated layer at the hydrogel–tissue interface, while the adhesive strength gap was further widened when the hydrogels were exposed to grease, which may be attributed to the self-lubricating effect of the grease.…”

Section: Resultsmentioning

confidence: 99%

Hydrogel-Integrated Multimodal Response as a Wearable and Implantable Bidirectional Interface for Biosensor and Therapeutic Electrostimulation

Sun

Xiao

et al. 2023

ACS Appl. Mater. Interfaces

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A hydrogel that fuses long-term biologic integration, multimodal responsiveness, and therapeutic functions has received increasing interest as a wearable and implantable sensor but still faces great challenges as an all-in-one sensor by itself. Multiple bonding with stimuli response in a biocompatible hydrogel lights up the field of soft hydrogel interfaces suitable for both wearable and implantable applications. Given that, we proposed a strategy of combining chemical cross-linking and stimuli-responsive physical interactions to construct a biocompatible multifunctional hydrogel. In this hydrogel system, ureidopyrimidinone/tyramine (Upy/Tyr) difunctionalization of gelatin provides abundant dynamic physical interactions and stable covalent cross-linking; meanwhile, Tyr-doped poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) acts as a conductive filler to establish electrical percolation networks through enzymatic chemical cross-linking. Thus, the hydrogel is characterized with improved conductivity, conformal biointegration features (i.e., high stretchability, rapid self-healing, and excellent tissue adhesion), and multistimuli-responsive conductivity (i.e., temperature and urea). On the basis of these excellent performances, the prepared multifunctional hydrogel enables multimodal wearable sensing integration that can simultaneously track both physicochemical and electrophysiological attributes (i.e., motion, temperature, and urea), providing a more comprehensive monitoring of human health than current wearable monitors. In addition, the electroactive hydrogel here can serve as a bidirectional neural interface for both neural recording and therapeutic electrostimulation, bringing more opportunities for nonsurgical diagnosis and treatment of diseases.

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Section: Resultsmentioning

confidence: 99%

Hydrogel-Integrated Multimodal Response as a Wearable and Implantable Bidirectional Interface for Biosensor and Therapeutic Electrostimulation

Sun

Xiao

et al. 2023

ACS Appl. Mater. Interfaces

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“…Liang et al used acrylic acid (AAc), CS, and TA to prepare low-swelling hydrogel Polymer-AAc/CS/TA (PAAc/CS/TA). 95 In this hydrogel, the CS chains entangled with each other and TA provided noncovalent interactions, which increased the cohesion and reduced the swelling rate of the hydrogel. Since Cl − and the N-glucosamine on the CS chain cannot attract each other in DIW, the swelling rate of hydrogel in DIW was slightly higher than that in PBS (Figure 7C).…”

Section: Anti-swelling Adhesive Hydrogelmentioning

confidence: 98%

“…Liang et al. used acrylic acid (AAc), CS, and TA to prepare low‐swelling hydrogel Polymer‐AAc/CS/TA (PAAc/CS/TA) 95 . In this hydrogel, the CS chains entangled with each other and TA provided non‐covalent interactions, which increased the cohesion and reduced the swelling rate of the hydrogel.…”

Section: Engineering Multifunctional Adhesive Hydrogelmentioning

confidence: 99%

Functional adhesive hydrogels for biological interfaces

Liu,

Peng,

et al. 2023

Smart Medicine

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Hydrogel adhesives are extensively employed in biological interfaces such as epidermal flexible electronics, tissue engineering, and implanted device. The development of functional hydrogel adhesives is a critical, yet challenging task since combining two or more attributes that seem incompatible into one adhesive hydrogel without sacrificing the hydrogel's pristine capabilities. In this Review, we highlight current developments in the fabrication of functional adhesive hydrogels, which are suitable for a variety of application scenarios, particularly those that occur underwater or on tissue/organ surface conditions. The design strategies for a multifunctional adhesive hydrogel with desirable properties including underwater adhesion, self‐healing, good biocompatibility, electrical conductivity, and anti‐swelling are discussed comprehensively. We then discuss the challenges faced by adhesive hydrogels, as well as their potential applications in biological interfaces. Adhesive hydrogels are the star building blocks of bio‐interface materials for individualized healthcare and other bioengineering areas.

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“…The obtained CS/TA/SF hydrogels showed less bleeding and shorter hemostasis time in various arterial and visceral bleeding models compared to previously reported materials (Figure 7a). Later in another study, Liang et al created a physicochemical double network cross-linked hydrogel (PCT) using acrylic acid, CS, and TA as the main components [97]. The hydrogels have many active sites on their surfaces, allowing fast, strong and repetitive adhesion to artificial solids and biological tissues (Figure 7b).…”

Section: Heartmentioning

confidence: 99%

Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces

Han

Wang

2022

Gels

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Currently, uncontrolled bleeding remains a serious problem in emergency, surgical and battlefield environments. Despite the specific properties of available hemostatic agents, sealants, and adhesives, effective hemostasis under wet and dynamic conditions remains a challenge. In recent years, polymeric hydrogels with excellent hemostatic properties have received much attention because of their adjustable mechanical properties, high porosity, and biocompatibility. In this review, to investigate the role of hydrogels in hemostasis, the mechanisms of hydrogel hemostasis and adhesion are firstly elucidated, the adhesion design strategies of hemostatic hydrogels in wet environments are briefly introduced, and then, based on a comprehensive literature review, the studies and in vivo applications of wet-adhesive hemostatic hydrogels in different environments are summarized, and the improvement directions of such hydrogels in future studies are proposed.

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Hydrogel adhesive formed via multiple chemical interactions: from persistent wet adhesion to rapid hemostasis

Abstract: Thus far, robust and durable adhesion capability of hydrogel adhesive in wet environment remains a huge challenge. Here, a chemically-physically double-network cross-linked hydrogel matrix was prepared by first mixing acrylic...

Cited by 20 publications

References 53 publications

Hydrogel-Integrated Multimodal Response as a Wearable and Implantable Bidirectional Interface for Biosensor and Therapeutic Electrostimulation

Hydrogel-Integrated Multimodal Response as a Wearable and Implantable Bidirectional Interface for Biosensor and Therapeutic Electrostimulation

Functional adhesive hydrogels for biological interfaces

Advances in Hemostatic Hydrogels That Can Adhere to Wet Surfaces

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