Hydrogel adhesives for generalized wound treatment: Design and applications

Abstract

Wound refers to the place where human body is injured and ruptured. So, wounds in a broad sense include not only skin wounds, but also damages of muscle, corneal, heart, and lung, etc. As "gold standard" of wound closure, suture and staple cause secondary damage to the tissue, and require professional skills and equipment, so noninvasive hydrogel adhesives have been developed as an alternative to close and treat different kinds of wounds. However, the existing reviews mainly discussed the research of hydrogel adhesives for skin wounds, and the focus is mostly on its types and adhesion mechanisms, but a review comprehensively discusses the design and application of hydrogel adhesives on generalized wounds for wound closure and wound healing and the unique needs of various wounds for hydrogel adhesives is still lacking. In this review, the types and adhesion mechanisms of hydrogel adhesives will be briefly described, then the research progress of hydrogel adhesives in wound treatment is reviewed in detail from two aspects: the comprehensive design principles and the unique requirements of different types of wounds. Overall, we expect that this review will provide guidance for the development of hydrogel adhesives as new avenues for generalized wound care and treatment.

Bioinspired gelatin based sticky hydrogel for diverse surfaces in burn wound care

“…2 e), indicating the abundance of hydrophilic O–H groups contributed by its components. Research indicates that the adhesives characteristics of hydrogels are mainly associated with the surface O–H groups of the hydrogel interacting with chemical groups such as hydroxyl, amino, and carboxyl on the surface of tissues 27 , 28 , 35 . The peak at 1141 cm −1 revealed C–O stretching arising due to the intermolecular hydrogen bonds formed between neighbouring PVA chains 36 .…”

Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application

“…The objective of wound healing enhancement is to quicken the wound repair, thereby preventing infections, reducing pain, removing dead tissue, supplying a humid environment, diminishing edemas, and increasing the flow of blood. Due to the physical, social, and financial impact of chronic ulcers and the difficulty in curing these skin problems with conventional treatments, researchers have recently been focusing on the progress of novel therapeutic procedures for wound treatments [ 31 ]. Despite several studies being conducted in the recent past working toward the development of a ‘perfect’ wound dressing biomaterial, there are no currently available materials that entirely accomplish the needed characteristics for a quick and enhanced injured tissue recovery.…”

Thermosensitive P(AAc‐co‐NIPAm) Hydrogels Display Enhanced Toughness and Self‐Healing via Ion–Ligand Interactions

“…This thermosensitive response, combined with the relatively soft adhesive strength of these gels, perhaps renders them suitable as self-removing adhesives used for wound dressing and tissue mending. [35][36][37]…”

“…The combination of high extensibility, toughness, thermosensitivity, self-healing capability, and adsorption of these gels gives them prospective applications in a wide array of fields, with potential applications including thermal biosensors, [34] self-healing soft actuators for wet environments, or self-removing adhesives for biomedical applications. [35][36][37]…”