Hydrogel Based Drug Delivery Systems: A Review with Special Emphasis on Challenges Associated with Decontamination of Hydrogels and Biomaterials

Kikuchi, Irene Satiko; Galante, Raquel; Dua, Kamal; Malipeddi, Venkata Ramana; Awasthi, Rajendra; Ghisleni, Daniela Dal Molim; Pinto, Terezinha de Jesus Andreoli

doi:10.2174/1567201813666161205130825

Cited by 24 publications

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“…This induces aggregation and chain entanglement, thus limiting solubility in water and most solvents [36]. The poor hydrophilicity could be interesting for drug delivery systems as the diffusion of drugs through the network is highly dependent on the water uptake [37]. A low water content affords a slow drug release and it is then possible to maintain a release over few weeks in comparison to a few days for more hydrophilic gels [38].…”

Section: Resultsmentioning

confidence: 99%

Polyaspartamide Functionalized Catechol-Based Hydrogels Embedded with Silver Nanoparticles for Antimicrobial Properties

et al. 2018

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In this study, polyaspartamide-based hydrogels were synthesized by boron-catechol coordination followed by incorporation of AgNPs into the materials. Free catechol moieties were exploited to produce AgNPs. TEM analyses displayed AgNPs of less than 20 nm in diameter and with minimum aggregation, attesting the role of hydrogels to act as an efficient template for the production of dispersed particles. XRD analyses confirmed the mean particle size using the Scherrer equation. Release kinetic studies were performed in DMEM medium, showing a slow release over a long time-period. Finally, the MIC and MBC were determined, demonstrating a bacteriostatic and bactericidal effect against Gram-positive S. aureus and Gram-negative E. coli.

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Section: Resultsmentioning

confidence: 99%

Polyaspartamide Functionalized Catechol-Based Hydrogels Embedded with Silver Nanoparticles for Antimicrobial Properties

et al. 2018

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“…A hydrogel-based system can also be utilized to release different therapeutic cargos, such as chemotherapeutics, proteins, and antibodies [ 44 , 45 ]. To this end, a gelatin-hydroproxyphenyl propionic acid (GHPA)-based hydrogel has been utilized to potentiate the antitumor immune response mediated by concomitant delivery of immune stimulatory oAd, which co-expresses interleukin (IL)-12 and granulocyte macrophage colony stimulating factor (GMCSF), and therapeutic dendritic cells (DCs) [ 46 ].…”

Section: Main Textmentioning

confidence: 99%

Overcoming the limitations of locally administered oncolytic virotherapy

Hong

Yun

2019

BMC biomed eng

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Adenovirus (Ad) has been most extensively evaluated gene transfer vector in clinical trials due to facile production in high viral titer, highly efficient transduction, and proven safety record. Similarly, an oncolytic Ad, which replicates selectively in cancer cells through genetic modifications, is actively being evaluated in various phases of clinical trials as a promising next generation therapeutic against cancer. Most of these trials with oncolytic Ads to date have employed intratumoral injection as the standard administration route. Although these locally administered oncolytic Ads have shown promising outcomes, the therapeutic efficacy is not yet optimal due to poor intratumoral virion retention, nonspecific shedding of virion to normal organs, variable infection efficacy due to heterogeneity of tumor cells, adverse antiviral immune response, and short biological activity of oncolytic viruses in situ. These inherent problems associated with locally administered Ad also holds true for other oncolytic viral vectors. Thus, this review will aim to discuss various nanomaterial-based delivery strategies to improve the intratumoral administration efficacy of oncolytic Ad as well as other types of oncolytic viruses.

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“…Three-dimensional PU structures are often found among those materials that are preferably used in medical applications due to their easy and cheap production as well as to their unique combination of biocompatibility, sterilizability, durability, good mechanical properties, abrasion, and chemical resistance (Kikuchi et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

et al. 2020

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Due to their effect of vasodilatation, isosorbide nitrates represent one of the most important and most used solutions for angina pectoris. Unfortunately, these compounds have multiple dose-related adverse drug reactions such as headache, weakness, mild dizziness, and occasionally heart rate changes, nausea, vomiting, and sweating. The main aims of this research were to obtain and to evaluate new polyurethane (PU) structures that can be used as a proper transmembrane carrier with an improved release kinetic. Chitosan-based PU structures were obtained by a polyaddition process between hexamethylene diisocyanate and a mixture of chitosan, butanediol, and polyethylene glycol in the presence of caffeine as a synthesis catalyst. The obtained samples (with and without isosorbide nitrates) were characterized regarding the encapsulation and release rate (UV-Vis spectra), chemical composition (FTIR), thermal stability (thermal analysis), morphology changes (SEM and SANS), and in vivo irritation tests. These methods revealed no significant differences between the two sample structures. Multipopulational structures with sizes between 73 and 310 nm, with an increased tendency to form clusters and a high resistance to heat (up to 280 • C), were obtained. This study presents an alternative administration of isosorbide derivatives based on a PU carrier with a high biocompatibility and a prolonged release.

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Hydrogel Based Drug Delivery Systems: A Review with Special Emphasis on Challenges Associated with Decontamination of Hydrogels and Biomaterials

Cited by 24 publications

References 0 publications

Polyaspartamide Functionalized Catechol-Based Hydrogels Embedded with Silver Nanoparticles for Antimicrobial Properties

Polyaspartamide Functionalized Catechol-Based Hydrogels Embedded with Silver Nanoparticles for Antimicrobial Properties

Overcoming the limitations of locally administered oncolytic virotherapy

Obtaining and Characterization of a Polydisperse System Used as a Transmembrane Carrier for Isosorbide Derivatives

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