Hydrogel-based immunoregulation of macrophages for tissue repair and regeneration

Nie, Rong; Zhang, Qing-Yi; Feng, Zi-Yuan; Huang, Kai; Zou, Chen-Yu; Fan, Ming-Hui; Zhang, Yue-Qi; Zhang, Ji-Ye; Li-Ling, Jesse; Tan, Bo; Xie, Hui-Qi

doi:10.1016/j.ijbiomac.2024.131643

Cited by 6 publications

(1 citation statement)

References 168 publications

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“…Achieving an appropriate balance between M1 and M2 macrophages to regulate the immune microenvironment has become a key pathway to accelerate tissue repair and regeneration. 135 Consequently, there is growing interest in developing hydrogels with precise immunomodulatory properties that can effectively regulate macrophage phenotypes, holding great promise for enhancing the therapeutic effectiveness of chronic wound treatments. In recent years, several immunomodulatory hydrogels based on macrophage reprograming have been developed for regenerative medicine, such as immunomodulatory hydrogels dependent on the intrinsic properties, hydrogel reservoirs for delivering immunomodulators, and nanohydrogel scaffolds for in situ regulation of immune cells.…”

Section: Reprograming Of Macrophages By Immunomodulatory Hydrogels Fa...mentioning

confidence: 99%

Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels

Sun,

Chang,

2024

J Tissue Eng

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Diabetic wound healing presents a significant clinical challenge due to the interplay of systemic metabolic disturbances and local inflammation, which hinder the healing process. Macrophages undergo a phenotypic shift from M1 to M2 during wound healing, a transition pivotal for effective tissue repair. However, in diabetic wounds, the microenvironment disrupts this phenotypic polarization, perpetuating inflammation, and impeding healing. Reprograming macrophages to restore their M2 phenotype offers a potential avenue for modulating the wound immune microenvironment and promoting healing. This review elucidates the mechanisms underlying impaired macrophage polarization toward the M2 phenotype in diabetic wounds and discusses novel strategies, including epigenetic and metabolic interventions, to promote macrophage conversion to M2. Hydrogels, with their hydrated 3D cross-linked structure, closely resemble the physiological extracellular matrix and offer advantageous properties such as biocompatibility, tunability, and versatility. These characteristics make hydrogels promising candidates for developing immunomodulatory materials aimed at addressing diabetic wounds. Understanding the role of hydrogels in immunotherapy, particularly in the context of macrophage reprograming, is essential for the development of advanced wound care solutions. This review also highlights recent advancements in immunotherapeutic hydrogels as a step toward precise and effective treatments for diabetic wounds.

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Section: Reprograming Of Macrophages By Immunomodulatory Hydrogels Fa...mentioning

confidence: 99%

Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels

Sun,

Chang,

2024

J Tissue Eng

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Multifunctional hydrogels for the healing of oral ulcers

Zhang,

Zhao,

Zou

et al. 2024

J Biomedical Materials Res

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Oral ulcers are one of the most common oral diseases in clinical practice. Its etiology is complex and varied. Due to the dynamic nature of the oral environment, the wound surface is painful due to contact and wear, which seriously affects the quality of life of patients. Oral ulcers are often treated with topical drug therapy. Studies have shown that functional hydrogels play a positive role in promoting wound healing, showing unique advantages in wound dressings. In this paper, the causes and healing characteristics of oral ulcers are discussed in depth, and then the common treatment methods for oral ulcers are summarized and compared. Finally, the potential of functional hydrogels in the treatment of oral ulcers is discussed and projected through a review of the literature in recent years.

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Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions

Zou,

Han,

Xing

et al. 2025

Bioactive Materials

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Hydrogel-based immunoregulation of macrophages for tissue repair and regeneration

Cited by 6 publications

References 168 publications

Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels

Immunomodulation in diabetic wounds healing: The intersection of macrophage reprogramming and immunotherapeutic hydrogels

Multifunctional hydrogels for the healing of oral ulcers

Smart design in biopolymer-based hemostatic sponges: From hemostasis to multiple functions

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