Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects

Li, Na; He, Jintao

doi:10.1016/j.ijbiomac.2024.134591

International Journal of Biological Macromolecules

2024

DOI: 10.1016/j.ijbiomac.2024.134591

|View full text |Cite

Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects

Na Li,

Jintao He

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 169 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Environment-tolerant, inherently conductive and self-adhesive gelatin-based supramolecular eutectogel for flexible sensor

Qiao,

Chen,

Pan

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Environment-tolerant, inherently conductive and self-adhesive gelatin-based supramolecular eutectogel for flexible sensor

Qiao,

Chen,

Pan

et al. 2024

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Biomimetic 3D Hydrogels with Aligned Topography for Neural Tissue Engineering

Severs,

Katta,

Cates

et al. 2024

Polymers

View full text Add to dashboard Cite

Spinal cord trauma leads to the destruction of the highly organized cytoarchitecture that carries information along the axis of the spinal column. Currently, there are no clinically accepted strategies that can help regenerate severed axons after spinal cord injury (SCI). Hydrogels are soft biomaterials with high water content that are widely used as scaffolds to interface with the central nervous system (CNS). Here, we examine a simple and reproducible method that results in consistently aligned fibrils within 3D matrices using thermally gelling biomimetic polymers. A collagen type I (Col)-based thermally gelling hydrogel system was used in combination with two other native extracellular matrix proteins: laminin I (LN) and hyaluronic acid (HA). Gelling kinetics for all gel types (Col, Col LN, Col HA) showed that at 37 °C, all three hydrogels formed gels consistently. A method of aspiration and ejection was used to produce Col-based hydrogels containing aligned fibrils. In vitro, embryonic spinal cord neurons survived and produced processes aligned to collagen fibrils. Next, we implanted either non-aligned or aligned hydrogels after a bilateral dorsal hemisection of the thoracic spinal cord at T7/T8. Pan neuronal antibody-positive fibrils were found within all implants; aligned hydrogels supported neurite growth along the parallel direction of the implanted hydrogels. Combined, our in vitro and in vivo data indicate that thermally gelling biomimetic hydrogels can produce aligned matrices through a method of aspiration and ejection, and this presents a novel platform for regenerative therapies for the CNS.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Hydrogel-based therapeutic strategies for spinal cord injury repair: Recent advances and future prospects

Cited by 2 publications

References 169 publications

Environment-tolerant, inherently conductive and self-adhesive gelatin-based supramolecular eutectogel for flexible sensor

Environment-tolerant, inherently conductive and self-adhesive gelatin-based supramolecular eutectogel for flexible sensor

Biomimetic 3D Hydrogels with Aligned Topography for Neural Tissue Engineering

Contact Info

Product

Resources

About