Hydrogel compression and polymer osmotic pressure

Bhattacharyya, Abir; O'Bryan, Christopher S.; Ni, Yongliang; Morley, Cameron; Taylor, Curtis R.; Angelini, Thomas E.

doi:10.1016/j.biotri.2020.100125

Cited by 33 publications

(17 citation statements)

References 20 publications

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“…After copolymerization with acrylamide (5 wt%) and N , N ′-methylenebis(acrylamide) (0.15 wt%), the DNA strands (5 mM) were incorporated into a polyacrylamide hydrogel to gate the pores via volume exclusion. The monomer and cross-linker concentrations were chosen such that the hydrogel mesh size was ∼10 nm (see SI, Section 3, for a detailed discussion on the hydrogel mesh size), , large enough to permit the efficient transport of common macromolecular cargo but small enough so that the pores can be gated efficiently by the gating DNA strands.…”

Section: Resultsmentioning

confidence: 99%

A General DNA-Gated Hydrogel Strategy for Selective Transport of Chemical and Biological Cargos

Distler

Cheng

et al. 2021

J. Am. Chem. Soc.

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The selective transport of molecular cargo is critical in many biological and chemical/materials processes and applications. Although nature has evolved highly efficient in vivo biological transport systems, synthetic transport systems are often limited by the challenges associated with fine-tuning interactions between cargo and synthetic or natural transport barriers. Herein, deliberately designed DNA−DNA interactions are explored as a new modality for selective DNA-modified cargo transport through DNA-grafted hydrogel supports. The chemical and physical characteristics of the cargo and hydrogel barrier, including the number of nucleic acid strands on the cargo (i.e., the cargo valency) and DNA−DNA binding strength, can be used to regulate the efficiency of cargo transport. Regimes exist where a cargo−barrier interaction is attractive enough to yield high selectivity yet high mobility, while there are others where the attractive interactions are too strong to allow mobility. These observations led to the design of a DNA-dendron transport tag, which can be used to universally modify macromolecular cargo so that the barrier can differentiate specific species to be transported. These novel transport systems that leverage DNA−DNA interactions provide new chemical insights into the factors that control selective cargo mobility in hydrogels and open the door to designing a wide variety of drug/probe-delivery systems.

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Section: Resultsmentioning

confidence: 99%

A General DNA-Gated Hydrogel Strategy for Selective Transport of Chemical and Biological Cargos

Distler

Cheng

et al. 2021

J. Am. Chem. Soc.

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“…Contact mechanics measurements, critical to evaluating the tribological performance of a hydrogel, performed in the linear-elastic range suggest that bulk hydrogel response to compressive loads is dependent upon the osmotic pressure of the hydrogel and is consistent with Hertzian predictions over several timescales [18,19]. Additional measurements showed that this was geometry dependent, suitable for solid (or thick) samples that lack sharp edges [20,21].…”

Section: Models Of Elasticity For Single and Multi-network Hydrogelsmentioning

confidence: 61%

“…However, as water has a size on the order of 3 angstroms, the smaller, thermally-active channel size is a significant hindrance to the flow rate through the bulk of the gel. It has been demonstrated for the water to pass through hydrogel bulk the osmotic pressure of the hydrogel must be exceeded by the pressing pressure [18,19]. For typical contact profiles under compression these pressures are not achievable under contact but are achievable with sharp shapes such as conics or knifes edges near the tip.…”

Section: Water-network Interactions and Flowmentioning

confidence: 99%

Review: Friction and Lubrication with High Water Content Crosslinked Hydrogels

et al. 2020

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As soft aqueous hydrogels have moved from new materials to the basis for real engineered devices in the last 20 years, their surface friction and lubrication are emerging as critical aspects of their function. The flexibility to alter and augment their mechanical and surface properties through control of the crosslinked 3D polymer networks has produced materials with diverse surface behaviors, even with the relatively simple composition of a single monomer and crosslink chemistry. Correspondingly with new understandings of the bulk behavior of hydrogels has been the identification of the mechanisms that govern the lubricity and frictional response under dynamic sliding conditions. Here we review these efforts, closely examining and identifying the internal and external influences that drive tribological response in high water content crosslinked hydrogels. The roles of surface structure, elasticity, contact response, charge, water interaction and water flow are addressed here as well as current synthesis and testing methods. We also collect open questions as well as the future needs to fully understand and exploit the surface properties of hydrogels for sliding performance.

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“…The utility of de Gennes' semi-dilute description is such that many properties of polymer solutions can be quantified using simple power-law relationships. In accordance with numerous studies [43][44][45], we assume the hydrogel can be thought of as a semi-dilute solution where the monomer concentration, c, is slightly higher than the overlap concentration, c * . At this semi-dilute state, polymer "blobs" are entangled with each other, creating an expansive polymer mesh.…”

Section: Dependence Of Stiffness On Swellingmentioning

confidence: 97%

Scaling laws to predict humidity-induced swelling and stiffness in hydrogels

Gao¹,

Chai²,

Garakani³

et al. 2021

Preprint

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From pasta to biological tissues to contact lenses, gel and gel-like materials inherently soften as they swell with water. In dry, low-relative-humidity environments, these materials stiffen as they de-swell with water. Here, we use semi-dilute polymer theory to develop a simple power-law relationship between hydrogel elastic modulus and swelling. From this relationship, we predict hydrogel stiffness or swelling at arbitrary relative humidities. Our close predictions of properties of hydrogels across three different polymer mesh families at varying crosslinking densities and relative humidities demonstrate the validity and generality of our understanding. This predictive capability enables more rapid material discovery and selection for hydrogel applications in varying humidity environments. * https://dattalab.princeton.edu/ † https://dakine.sites.unlv.edu/

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Hydrogel compression and polymer osmotic pressure

Cited by 33 publications

References 20 publications

A General DNA-Gated Hydrogel Strategy for Selective Transport of Chemical and Biological Cargos

A General DNA-Gated Hydrogel Strategy for Selective Transport of Chemical and Biological Cargos

Review: Friction and Lubrication with High Water Content Crosslinked Hydrogels

Scaling laws to predict humidity-induced swelling and stiffness in hydrogels

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