Hydrogel Functionalized Janus Membrane for Skin Regeneration

Abstract

In this study, a hydrogel functionalized Janus membrane is developed and its capacity is examined as a wound dressing biomaterial. A hydrophobic fluoropolymer, poly(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl methacrylate) (PHFDMA), is uniformly coated onto macroporous polyester membrane through initiated chemical vapor deposition process on both sides. PHFDMA-coated macroporous membrane exhibits antibacterial property, allows air permeation, and inhibits water penetration. Janus membrane property is obtained by exposing one side of PHFDMA coated membrane with 1 m KOH solution, which allows PHFDMA cleavage resulting in carboxylic acid residue. This carboxylic acid residue is then further functionalized with gelatin methacrylate-based photocrosslinkable hydrogel for moisture retention and growth factor release. When applied to full thickness dorsal skin defect model, functionalized hydrogel allows moisture retention and hydrophobic surface prevents exudate leaks via water repellence. Furthermore, hydrogel functionalized Janus membrane enhances the wound healing rate and induces thick epidermal layer formation. In conclusion, the multifunctional Janus membrane with hydrophobic outer surface and immobilized hydrogel on the other surface is fabricated for an innovative strategy for wound healing.

Janus Membranes: Creating Asymmetry for Energy Efficiency

“…Moreover, Janus membranes display great potential in unconventional field. For example, by taking advantage of their asymmetric structure, Janus membranes can also serve as a passive cooler for temperature control, as an interfacial reactor for electrocatalysis, or as a protective layer on a biomedical hydrogel for skin regeneration …”

Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis

“…To provide a strong conductive medium from the RED battery to the PYP hydrogel, we applied a highly conductive carbon paste onto the nonwoven fabric that is designed to hold the PYP hydrogel (Figure E) . The carbon-printed fabric displayed a less porous structure than the naïve fabric surface and had excellent electrical conductivity comparable to Au-coated glass (Figure S7).…”

Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring

“…In situ gelling on wounds demonstrated considerable prospects in achieving an accurate fit with irregular shape tissue defects. Hydrogel allows moisture retention with minimized exudate leaks, which could play a potentially critical role in wound protection [ 12 ]. Moreover, the loose and porous structure in the gel contributes to the slow release of cytokines in the conditioned medium [ 13 ].…”