Hydrogel Magnetomechanical Actuator Nanoparticles for Wireless Remote Control of Mechanosignaling <i>In Vivo</i>

Jeong, Sumin; Shin, Wookjin; Park, Mansoo; Lee, Jung-uk; Lim, Yongjun; Noh, Kunwoo; Lee, Jae‐Hyun; Jun, Young‐wook; Kwak, Myung-Jun; Cheon, Jinwoo

doi:10.1021/acs.nanolett.3c01207

Cited by 10 publications

(10 citation statements)

References 73 publications

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“…This contraction generates forces that activate specific mechanoreceptors, leading to subsequent downstream signaling processes. 63 These aforementioned magnetomechanical methods require the ectopic expression of mechanosensory ion channels such as Piezo1 and Notch1. 22,63 In a study by the Anikeeva laboratory, dorsal root ganglion (DRG) neurons, featuring endogenous mechanoreceptors Piezo2 and TRPV4, were utilized (Figure 4d).…”

Section: ■ Neuromodulation Methods With Mechanical Force As the Secon...mentioning

confidence: 99%

“…Subsequently, this thermal energy induces mechanical action by causing the surrounding polymer shell, made of poly- N -isopropylmethylacrylamide (pNiPMAm), to contract. This contraction generates forces that activate specific mechanoreceptors, leading to subsequent downstream signaling processes …”

Section: Neuromodulation Methods With Mechanical Force As the Seconda...mentioning

confidence: 99%

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Force-Based Neuromodulation

Cooper,

Malinao,

Hong

2024

Acc. Chem. Res.

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Metrics & MoreArticle Recommendations CONSPECTUS: Technologies for neuromodulation have rapidly developed in the past decade with a particular emphasis on creating noninvasive tools with high spatial and temporal precision.The existence of such tools is critical in the advancement of our understanding of neural circuitry and its influence on behavior and neurological disease. Existing technologies have employed various modalities, such as light, electrical, and magnetic fields, to interface with neural activity. While each method offers unique advantages, many struggle with modulating activity with high spatiotemporal precision without the need for invasive tools. One modality of interest for neuromodulation has been the use of mechanical force. Mechanical force encapsulates a broad range of techniques, ranging from mechanical waves delivered via focused ultrasound (FUS) to torque applied to the cell membrane. Mechanical force can be delivered to the tissue in two forms. The first form is the delivery of a mechanical force through focused ultrasound. Energy delivery facilitated by FUS has been the foundation for many neuromodulation techniques, owing to its precision and penetration depth. FUS possesses the potential to penetrate deeply (∼centimeters) into tissue while maintaining relatively precise spatial resolution, although there exists a trade-off between the penetration depth and spatial resolution. FUS may work synergistically with ultrasound-responsive nanotransducers or devices to produce a secondary energy, such as light, heat, or an electric field, in the target region. This layered technology, first enabled by noninvasive FUS, overcomes the need for bulky invasive implants and also often improves the spatiotemporal precision of light, heat, electrical fields, or other techniques alone. Conversely, the second form of mechanical force modulation is the generation of mechanical force from other modalities, such as light or magnetic fields, for neuromodulation via mechanosensitive proteins. This approach localizes the mechanical force at the cellular level, enhancing the precision of the original energy delivery. Direct interaction of mechanical force with tissue presents translational potential in its ability to interface with endogenous mechanosensitive proteins without the need for transgenes.In this Account, we categorize force-mediated neuromodulation into two categories: 1) methods where mechanical force is the primary stimulus and 2) methods where mechanical force is generated as a secondary stimulus in response to other modalities. We summarize the general design principles and current progress of each respective approach. We identify the key advantages of the limitations of each technology, particularly noting features in spatiotemporal precision, the need for transgene delivery, and the potential outlook. Finally, we highlight recent technologies that leverage mechanical force for enhanced spatiotemporal precision and advanced applications.

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Section: ■ Neuromodulation Methods With Mechanical Force As the Secon...mentioning

confidence: 99%

Section: Neuromodulation Methods With Mechanical Force As the Seconda...mentioning

confidence: 99%

Force-Based Neuromodulation

Cooper,

Malinao,

Hong

2024

Acc. Chem. Res.

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“…With appropriate compositions, the scaffold materials can preserve the structural integrity and the location of the nanomaterials while the incorporated nanomaterials can present their functions. There are several nanoparticles with specifically physical properties that have been used to functionalize the scaffolds, such as magnetic nanoparticles, [207] thermal-sensitive nanoparticles, [208,209] pH-sensitive nanoparticles. [210] These functional nanoparticles can be immobilized into the scaffolds via physical/chemical methods during or after fabrication.…”

Section: Nanomaterials For Other Functionsmentioning

confidence: 99%

Advanced Nanomaterials in Medical 3D Printing

Liu,

He,

Kuzmanović

et al. 2023

Small Methods

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Abstract3D printing is now recognized as a significant tool for medical research and clinical practice, leading to the emergence of medical 3D printing technology. It is essential to improve the properties of 3D‐printed products to meet the demand for medical use. The core of generating qualified 3D printing products is to develop advanced materials and processes. Taking advantage of nanomaterials with tunable and distinct physical, chemical, and biological properties, integrating nanotechnology into 3D printing creates new opportunities for advancing medical 3D printing field. Recently, some attempts are made to improve medical 3D printing through nanotechnology, providing new insights into developing advanced medical 3D printing technology. With high‐resolution 3D printing technology, nano‐structures can be directly fabricated for medical applications. Incorporating nanomaterials into the 3D printing material system can improve the properties of the 3D‐printed medical products. At the same time, nanomaterials can be used to expand novel medical 3D printing technologies. This review introduced the strategies and progresses of improving medical 3D printing through nanotechnology and discussed challenges in clinical translation.

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“…10A). 40 A variety of magnetic materials, including iron oxide nanoparticles (such as Fe 3 O 4 and Fe 2 O 3 ), ferrite particles, and magnetic alloys 249–252 have been used for magnetomechanical stimulation. Lee et al designed an m-Torquer system composed of a magnetic torque based on assembled octahedral zinc-doped ferrimagnetic nanoparticles (Zn 0.4 Fe 2.6 O 4 ) (Fig.…”

Section: Functional Material-mediated Wireless Physical Signals For N...mentioning

confidence: 99%

“…10D2 and D3). 40 We believe that by integrating magnetic materials into biomimetic hydrogels, the role of magnetomechanical stimulation in tissue regeneration, especially nerve regeneration, can be thoroughly revealed in the future.…”

Section: Functional Material-mediated Wireless Physical Signals For N...mentioning

confidence: 99%