Hydrogel microspheres III. Temperature-dependent adsorption of proteins on poly-N-isopropylacrylamide hydrogel microspheres

Kawaguchi, Haruma; Fujimoto, Keiji; Mizuhara, Yoshiro

doi:10.1007/bf00656929

Cited by 280 publications

(197 citation statements)

References 7 publications

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“…The LCST thermograms obtained by DSC measurements for S-N and S-N-H gels are shown in Figure 8, which can evaluate the chain flexibility of PNIPAAm. The phase transition was unobservable in S-N gel with high clay content (more than 5wt%), due to the limitation of the coil-globule conformation change of PNIPAAm chains throughout the temperature range examined [9]. From Figure 8 …”

Section: Lcst Behavior Of S-n and S-n-h Gelsmentioning

confidence: 94%

“…Hydrophobic interactions between isopropyl groups increased and the hydrogels appeared to be hydrophobic and the PNIPAAm chains started to aggregate and phase separation took place. Also, it was well known that high clay content would decelerate deswelling rates [9], due to the hydrophilicization influence of clay platelets on the coil-globule conformation change of PNIPAAm chains [20][21]. Because the FTIR results showed that the chemical components of S-N gel did not change through the post treatment, the improvement of deswelling rate of S-N-H gels should result from the change in the physical structure of the hydrogel network [12].…”

Section: Swelling Behavior Of S-n and S-n-h Gelsmentioning

confidence: 99%

“…It is found that with increasing clay content, mechanical properties of the S-N gels increased, but the swelling/deswelling rate and ratio of those are gradually decreased. This demerit makes it inadequate for applications such as drug delivery systems [6], separation devices [7], micro-scale actuators [8] and recyclable absorbents [9], etc.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel rapid response clay/poly(N-isopropylacrylamide) nanocomposite hydrogels by post treatment with HCl solution

Ma¹,

Liu²,

Jiang³

et al. 2007

E-Polymers

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A series of high clay content Laponite XLS/poly (N-isopropylacrylamide) (PNIPAAm) nanocomposite hydrogels (S-N gels) have been successfully prepared by in-situ ultraviolet (UV) initiated polymerization. The effects of post treatment with HCl solution on swelling/deswelling behaviour of the S-N gels have been investigated in detail. The results indicate that the Laponite XLS/PNIPAAm nanocomposite hydrogels with HCl solution post treatment (S-N-H gels) exhibit great swelling ratio and rapid deswelling response rate; much higher and faster than other reported clay/PNIPAAm nanocomposite hydrogels. IntroductionIn the last two decades, Poly (N-isopropylacrylamide) (PNIPAAm) hydrogels have attracted much attention as the advanced soft materials because of thermo-sensitivity, resulting from phase transition at their lower critical solution temperature (LCST≈32 °C) [1]. Due to the coexistence of hydrophilic (amide) and hydrophobic (N-isopropyl) groups, PNIPAAm chains are hydrated, expanded, flexible random-coil conformations below the LCST; dehydrated and collapse to globular conformations above the LCST [2].

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Section: Lcst Behavior Of S-n and S-n-h Gelsmentioning

confidence: 94%

Section: Swelling Behavior Of S-n and S-n-h Gelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel rapid response clay/poly(N-isopropylacrylamide) nanocomposite hydrogels by post treatment with HCl solution

Ma¹,

Liu²,

Jiang³

et al. 2007

E-Polymers

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show abstract

“…11, it can be concluded that the template and non-template proteins were all accumulated on the surface of the PNIPAM layer. The interaction between the PNIPAM and the proteins is mainly a hydrophobic effect at temperatures higher than the T vpt (volume phase transition temperature) [34][35][36]. The hydrophobic interaction is non-specific, so the coated MIP beads could randomly adsorb both the template lysozyme and the reference proteins on the outer PNIPAM layer (lane 6).…”

Section: Thermosensitive Selective Characteristicsmentioning

confidence: 99%

Molecularly imprinted beads with double thermosensitive gates for selective recognition of proteins

Qin

Yuan

et al. 2011

Anal Bioanal Chem

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A new approach is reported on the use of poly(Nisopropylacrylamide) (PNIPAM)-coated molecularly imprinted beads (coated MIP beads) for controlling the release of protein. The coated MIP beads were composed of double layers, an internal thermosensitive lysozymeimprinted layer, and an external PNIPAM layer. The coated MIP beads were prepared by two-step surface-initiated living-radical polymerization (SIP). In this systemic study, the coated MIP beads had good selectivity to the template protein (lysozyme) and temperature stimulus-responsive behavior, both of which were superior to those of MIP beads having a layer of thermosensitive lysozyme-imprinted polymer only. Using the coated MIP beads, reference proteins and the template lysozyme could be released separately at 38°C and at 23°C. The corresponding coated non-imprinted beads (coated NIP beads) did not have such double thermosensitive "gates" with specific selectivity for a particular protein. The proposed smart controlled imprinted system for protein is attractive for chemical carriers, drugdelivery system, and sensors.

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“…Such advanced materials, especially those stimuli-responsive polymers and gels have been actively investigated due to a unique nature of volume change in response to external stimuli [13]. These self-oscillating gel particles have various potential industrial applications, such as drug delivery [14], chemical and biosensing [15], fabrication of photonic crystals [16] and absorbents [17].…”

Section: Introductionmentioning

confidence: 99%

Self-Oscillating Structural Polymer Gels

Pullela¹,

Wang²,

Cheng³

2013

ANP

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Self-oscillating polymer gel has become a distinguished class of smart soft materials. Here we fabricated and demonstrated a self-oscillating structural gel network with the incorporation of the Belousov-Zhabotinsky (BZ) reaction. The structural polymer gel oscillates at a macroscopic level with remarkably faster kinetics compared to a normal gel of similar chemical compositions. The structural polymer gel also displays larger oscillating amplitude compared to the normal gel because of the increased diffusion of fluids surrounding the gel particles. This type of structural polymer gels can be harnessed to provide novel and feasible applications in a wide variety of fields, such as drug delivery, nanopatterning, chemical and biosensing, and photonic crystals.

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Hydrogel microspheres III. Temperature-dependent adsorption of proteins on poly-N-isopropylacrylamide hydrogel microspheres

Cited by 280 publications

References 7 publications

Novel rapid response clay/poly(N-isopropylacrylamide) nanocomposite hydrogels by post treatment with HCl solution

Novel rapid response clay/poly(N-isopropylacrylamide) nanocomposite hydrogels by post treatment with HCl solution

Molecularly imprinted beads with double thermosensitive gates for selective recognition of proteins

Self-Oscillating Structural Polymer Gels

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