Hydrogel nanotubes with ice helices as exotic nanostructures for diabetic wound healing

Singh, Aarti; Bhattacharya, Rohan; Shakeel, Adeeba; Sharma, Arun Kumar; Jeevanandham, Sampathkumar; Kumar, Ashish; Chattopadhyay, S.; Bohidar, H. B.; Ghosh, Sourabh; Chakrabarti, Sandip; Rajput, Satyendra K.; Mukherjee, Monalisa

doi:10.1039/c8mh01298a

Cited by 20 publications

(21 citation statements)

References 62 publications

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“…The prepared hydrogel samples were applied at the wound sites as our previously reported study. 33 Figure 5 shows the images of the rat skin wounds taken at different time intervals after treating with a marketed standard, pDMAEMA–HA hydrogel, and pDPi-DMAEMA–HA hydrogel. The control group (without treatment) was also included with no sign of inflammation and infection occurring.…”

Section: Resultsmentioning

confidence: 99%

“… 35 , 36 Our previously reported study demonstrated that hydrogel nanotubes exhibited unique biocompatibility and helped in the rapid establishment of wound barrier properties with concomitant cell proliferation guided by the provisional matrix mimicking an extracellular matrix niche, which support permissive milieu for vascular sufficiency with a well-proliferated fibroblast at the wound bed. 33 In addition, cell migration and proliferation efficacy in vitro and contractile force generated by HA could be the reason of the excellent healing performance of these hydrogels. 33 …”

Section: Resultsmentioning

confidence: 99%

“…The wound area were measured on day 3, 7, 11, and 14 after treatment using a Vernier caliper and represented as wound contraction. 33 , 39 Percentage of wound contraction was determined taking the initial size of the wound as 100% using the following formula …”

Section: Methodsmentioning

confidence: 99%

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Acceleration of Wound Healing in Diabetic Rats through Poly Dimethylaminoethyl Acrylate–Hyaluronic Acid Polymeric Hydrogel Impregnated with a Didymocarpus pedicellatus Plant Extract

et al. 2020

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Wound is the major health problem associated with skin damages and arises because of various types of topical injuries. Furthermore, wounds in patients with diabetes take a relatively long time to heal. Currently, herbal medicines have been extensively used for wound care and management. Here, we engineered polymeric hybrid hydrogel of dimethylaminoethyl acrylate and hyaluronic acid (pDMAEMA–HA), which was impregnated with a herbal extract of Didymocarpus pedicellatus . The developed polymeric hybrid hydrogel system can be used for effective therapy of incurable wounds. Therefore, the development of D. pedicellatus -impregnated pDMAEMA–HA (pDPi-DMAEMA–HA) hybrid hydrogel was accomplished by the synthesis of pDMAEMA–HA hydrogel via the optimization of various reaction parameters followed by impregnation of herbal drugs D. pedicellatus . The developed hydrogel composite was well characterized via various techniques, and swelling kinetics was performed to analyze the water uptake property. The swelling ratio was found to be 1600% in both types of hydrogels. To evaluate the wound healing of these polymeric hydrogels, the Wistar rats full-thickness excision wound model was utilized. The healing strength of hydrogels was determined using measurement of wound contraction and histopathological study. The results of wound healing by these polymeric hydrogels revealed that animals treated with the pDPi-DMAEMA–HA hybrid hydrogel group were found to have a higher level of wound closure as compared to marketed formulation as well as polymeric hybrid hydrogel. The histopathologic examinations implied that pDPi-DMAEMA–HA hybrid hydrogel and polymeric hybrid hydrogel-treated groups exhibited enhanced cutaneous wound repair as well as high level of cellular repair and maintenance compared to the standard group because of hyaluronic acid roles in various stages of wound repair.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Acceleration of Wound Healing in Diabetic Rats through Poly Dimethylaminoethyl Acrylate–Hyaluronic Acid Polymeric Hydrogel Impregnated with a Didymocarpus pedicellatus Plant Extract

et al. 2020

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“…32 Hydrogels are highly water-swollen networks made of hydrophilic polymers with tunable mechanical, physical and chemical characteristics. 33–35 The high-water content of hydrogels makes it easier and faster for nutrient and waste transport in the network. 36 Compared with other culture systems, most hydrogels can be formed under mild conditions and can be modified to possess the desired properties such as cell adhesion, 37 viscoelastic features 31,38 and degradability.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in 3D hydrogel culture systems for mesenchymal stem cell-based therapy and cell behavior regulation

Xia

Cai

2022

J. Mater. Chem. B

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“…The cellular response promotes phagocytosis and removal of dead tissue to promote the generation of healthy tissues. Remodeling phase, in partial-thickness burns proliferation phases, starts by reepithelization, in the form of keratinocyte migration from skin appendages with few hours of injury, which usually requires 5-7 d for complete wound coverage, followed by the formation of basement membrane zone between dermis and epidermis [3]. Angiogenesis and fibrogenesis promote the reconstruction of the dermis, followed by maturation of graft or scar.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Evaluation of Copper Nanoparticles Loaded Hydrogel for Burns

Kumar

Pandit²,

Nagaich

2021

Int J App Pharm

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Objective: The present study focuses on the development and optimization of copper nanoparticles (CNPs) loaded hydrogel for the treatment of dermal burn injuries. Methods: CNPs gel was prepared by dispersing the variable concentration of polyvinylpyrrolidone (PVP K30) and hydroxypropyl methylcellulose (HPMC) in distilled water, PEG 400, and copper nanoparticles. factor screening study was performed for identification of influential factors, followed by optimization study using three-factor Box-Behnken design. Results: Optimized nanogel formulation, when compared to normal control (NC), shows a significant reduction of pro-inflammatory cytokines (IL-6 = 39.74 % and TNF-α =49.37%) and increased level of anti-inflammatory cytokines (IL-10 = 30.90%), indicating reduced inflammation. Further, the wound closure rate of CNPs gel shows significant (12.27 %) wound closure as compared to the NC group and complete wound closure (100 %) on the 14th day, indicating accelerated wound healing. Conclusion: the present investigation endorses accelerated scar-free, accelerated wound healing potential of copper nanoparticles gel with anti-inflammatory potential.

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Hydrogel nanotubes with ice helices as exotic nanostructures for diabetic wound healing

Abstract: Hydrogel nanotubes with ice helices entrapped within their internal conduits are a promising material for diabetic wound healing.

Cited by 20 publications

References 62 publications

Acceleration of Wound Healing in Diabetic Rats through Poly Dimethylaminoethyl Acrylate–Hyaluronic Acid Polymeric Hydrogel Impregnated with a Didymocarpus pedicellatus Plant Extract

Acceleration of Wound Healing in Diabetic Rats through Poly Dimethylaminoethyl Acrylate–Hyaluronic Acid Polymeric Hydrogel Impregnated with a Didymocarpus pedicellatus Plant Extract

Recent advances in 3D hydrogel culture systems for mesenchymal stem cell-based therapy and cell behavior regulation

Preparation and Evaluation of Copper Nanoparticles Loaded Hydrogel for Burns

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