Hydrogel Networks Based on Aba Triblock Copolymers

Tartivel, Lucile; Behl, Marc; Schroeter, Michael; Lendlein, Andreas

doi:10.5301/jabfm.2012.10295

Cited by 6 publications

(14 citation statements)

References 17 publications

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“…However, hydrogel networks prepared from M n = 14600 g·mol -1 showed larger and sharper transitions in terms of swellability, volume shrinking and loss modulus. These observations can be attributed to the higher mechanical flexibility of those hydrogels, and therefore to a higher degree of freedom of the crosslinked monomers to form hydrophobic domains when the temperature is increased, which complements the results of our previous study [6]. Such hydrogels fabricated from biocompatible monomers and with demonstrated tunable properties and thermo-sensitivity at physiological temperatures can be considered as relevant candidates for thermo-sensitive drug delivery system.…”

Section: Discussionsupporting

confidence: 79%

“…The same tendency was observed for 8K(yy) networks. A systematic comparison between G' and G'' of hydrogels prepared from OEG-OPG-OEG block copolymer from different M n but with similar precursors concentration showed that 15K(yy) samples were of lower mechanical strength than 8K(yy) gels, which is in good correlation with its higher swellability as well as with our previous study [6]. As the linear oligomers are thermo-sensitive, it was explored whether this thermosensitivity could also influence the mechanical properties of the crosslinked hydrogel networks ( Figure 4).…”

Section: Mechanical Propertiessupporting

confidence: 77%

“…G was higher for 8K(yy) samples than for 15K(yy) ones and increased with the monomer concentration. In general, G was lower for these networks, synthesized at 5 °C, than those described in our previous work [6], which were synthesized at room temperature. This difference can be attributed to the thermo-sensitive behavior of OEG-OPG-OEG block copolymers solutions which already form micelles at room temperature.…”

Section: Gel Content and Swellabilitymentioning

confidence: 88%

“…After verifying that all measurements were performed in the linear viscoelastic region for all samples, a constant deformation of = 0.002 was applied for all frequency-and temperature-dependent measurements. Temperature sweeps were performed between 1 and 60 °C with a frequency f = 0.15 Hz and a constant force of F = 0.10 N. Other characterization methods were performed as described in reference [6].…”

Section: Characterization Methodsmentioning

confidence: 99%

“…The functionalization of OEG-OPG-OEG of M n = 8400 g·mol -1 and M n = 14600 g·mol -1 with 2-isocyanate ethyl methacrylate (IEMA) was performed as described in reference [6]. The hydrogel networks were prepared from OEG-OPG-OEG-IEMA monomer solutions, in concentration 10 wt%, 20 wt% and 30 wt% in water for injection (WFI).…”

Section: Synthesismentioning

confidence: 99%

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ABA triblock copolymer based hydrogels with thermo-sensitivity for biomedical applications

et al. 2013

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Oligo(ethylene glycol)-oligo(propylene glycol)-oligo(ethylene glycol) (OEG-OPG-OEG) triblock copolymers are hydrogel forming and extensively investigated in the field of drug release due to their biocompatibility and thermo-sensitivity. Here the synthesis and characterization of OEG-OPG-OEG based polymer networks from methacrylated oligomers by photo-irradiation are reported. Two precursors were selected to have comparable hydrophilicity (80 wt% OEG content) but different molecular weights of M n = 8400 g·mol -1 and 14600 g·mol -1 . The precursor solutions were prepared in concentration 10 to 30 wt%. The resulting polymer networks prepared from high M n precursors exhibited higher swellability at equilibrium (up to 3400%) and mechanical properties in the range of G' ~ 0.1 to 1 kPa at 5 °C compared to networks based on low M n precursors. A more significant thermo-sensitive behavior in terms of swellability, volumetric contraction and mechanical transition, starting at 30 °C could also be observed for the networks based on high M n precursors, thus promoting future application in the field of drug release.

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Section: Discussionsupporting

confidence: 79%

Section: Mechanical Propertiessupporting

confidence: 77%

Section: Gel Content and Swellabilitymentioning

confidence: 88%

Section: Characterization Methodsmentioning

confidence: 99%

Section: Synthesismentioning

confidence: 99%

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ABA triblock copolymer based hydrogels with thermo-sensitivity for biomedical applications

et al. 2013

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An Inverse Shape‐Memory Hydrogel Scaffold Switching Upon Cooling in a Tissue‐Tolerated Temperature Range

Tartivel

Blocki

Braune

et al. 2022

Adv Materials Inter

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either by covalent or physical interaction) is heated above a thermal transition temperature T trans (a glass (T g ) or melting transition temperature (T m )) associated to the switching domains and deformed into a new shape. The temporary shape is obtained after cooling of the sample below T trans and release of external stress. This temporary shape is stable until it is exposed to heat and a switching temperature T sw is exceeded. If the SME is triggered, the material recovers its original shape. It is a one-way effect, meaning that the original shape will not change upon cooling. The fixation of the temporary shape is caused by the formation of temporary cross-links in addition to the netpoints of the polymer network (e.g., phase transition within a semi-crystalline matrix). Various material concepts with sophisticated functions and abilities based on this technology have been reported, [2] e.g., in triblock copolymers from poly(raclactide)-b-poly(propylene oxide)-b-poly(raclactide) dimethacrylates the classical SME functionality based on the T g of the poly(rac-lactide segments) could be combined with degradability. [3] In addition to the classical SME, materials with advanced functions such as triple-or multi-shape-effect were created. [1b,4] Similarly to classical SME, in triple-or multi-shapeeffect polymers the temporary shape is reversed by heating.SME materials have great potential in biomedical application scenarios spanning from a SMP-based self-tightening suture for wound closure up to stents or aneurysm occlusion devices. [5] Of special interest are application scenarios for minimally invasive surgery based on their capability to change shape. So far SMP became elastic when heated. It was the aim of this study to design and fabricate a cell-compatible poly mer-based network with a cooling-induced inverse SME (iSME) within a tissue-tolerated temperature range. In case of an iSME the temporary shape is stable until the material is cooled to T sw . In analogy to the SME, the iSME is a one-time, one-way effect. Once the original shape is recovered, the material does not switch back. Even if heated again, the material remains in its permanent shape obtained during cooling. In this way iSME materials differ from soft artificial muscles (actuators [6] ), who lose their shape obtained during cooling when heated. Potential applications for such a biomaterial system with an iSME are envisaged in soft tissue reconstruction where the device needs to be placed minimally invasively.Soft tissue reconstruction faces various challenges. Current clinically established approaches are based on multiple surgical Tissue reconstruction has an unmet need for soft active scaffolds that enable gentle loading with regeneration-directing bioactive components by soaking up but also provide macroscopic dimensional stability. Here microporous hydrogels capable of an inverse shape-memory effect (iSME) are described, which in contrast to classical shape-memory polymers (SMPs) recover their permanent shape upon cooling. These hyd...

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Immuno‐compatibility of amphiphilic ABA triblock copolymer‐based hydrogel films for biomedical applications

Görs

Roch

Tartivel

et al. 2015

Polymers for Advanced Techs

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The protein adsorption and immuno-compatibility of hydrogels largely influence the clinical outcome in biomedical application scenarios. In this study photo-crosslinked 2-isocyanate ethyl methacrylate-functionalized oligo(ethylene glycol)-oligo(propylene glycol)-oligo(ethylene glycol) (IEMA-OEG-OPG-OEG-IEMA)-based polymer hydrogel films were explored with respect to endotoxin contaminations, intrinsic immuno-modulatory features, and protein adsorption of human fibronectin as well as serum albumin. Therefore three different hydrogel films were prepared from aqueous solutions of dimethacrylated OEG-OPG-OEG triblock copolymers (M n = 12,700 g mol À1 , 70 mol% OEG content) with varying wt% of the macromonomer (10 to 30%) resulting in polymeric networks, which differ in their crosslinking density and accordingly their physical properties. It could be shown that all three hydrogel film compositions do not cause complement and immune cell activation. The films were protein repellent, but reversible protein diffusion in and out of the hydrogel network, depending on the mesh size of the network, could be observed. In conclusion, the hydrogels can be considered as immuno-compatible, which qualifies them for biomedical applications such as drug release systems.

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Hydrogel Networks Based on Aba Triblock Copolymers

Cited by 6 publications

References 17 publications

ABA triblock copolymer based hydrogels with thermo-sensitivity for biomedical applications

ABA triblock copolymer based hydrogels with thermo-sensitivity for biomedical applications

An Inverse Shape‐Memory Hydrogel Scaffold Switching Upon Cooling in a Tissue‐Tolerated Temperature Range

Immuno‐compatibility of amphiphilic ABA triblock copolymer‐based hydrogel films for biomedical applications

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