Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine

Abstract

Abstract:The gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to TSP 6) series were prepared using tamarind powder:xanthan in the ratios of 5:0, 4:1, 3:2, 2:3, 1:4, 0:5, respectively. The matrix tablets were prepared by the wet granulation method and evaluated for pharmacopoeial requirements. TKP2 was the optimum formulation as it had a short floating lag time (FLT < 30 s) and more than 98.5% drug release in 12 h. The dissolution data were fitted to popular mathematical models to assess the mechanism of drug release, and the optimum formulation showed a predominant first order release and diffusion mechanism. It was concluded that the TKP2 prepared using tamarind kernel powder:xanthan (4:1) was the optimum formulation with shortest floating lag time and more than 90% release in the determined period of time.

Gastroretentive behavior of orally administered radiolabeled tamarind seed formulations in rabbits validated by gamma scintigraphy

“…Then, the complete de-husked seed particles were subsequently ground into powder (TKP) using a blender machine and sieved into 0.149 mm using a no 100 sieve. On the other hand, TSP was produced by grinding the whole seed including the husk, and the whole seed was fed into the cutting mill machine to be converted to small particle size and then powdered using a blender and finally passed through a no 100 sieve to standardize the size of particles 21. The TSP and TKP were then stored in an airtight polypropylene bottle and kept in a desiccator until use 21…”

“…The binder solution (1% w/v xanthan) was used to granulate the powder mixture; then the granules were sieved into 2 mm using a no 10 sieve and dried out at 50°C in a hot air oven to reach a constant moisture level; then sieve no 18 was used to sieve the dried granules to obtain a uniform size of 1 mm. Premixed talc and magnesium stearate were added to them and mixed well to achieve a uniform blend 21. The lubricated granules (783 mg) were manually loaded into the die cavity and compressed into tablet form via a Manual Type Single Punch Tablet Press machine (MTCM-I; GlobePharma, North Brunswick, NJ, USA) using a round, concave 12 mm caplet punch and compressed at 2200 N 21,22…”

“…Premixed talc and magnesium stearate were added to them and mixed well to achieve a uniform blend 21. The lubricated granules (783 mg) were manually loaded into the die cavity and compressed into tablet form via a Manual Type Single Punch Tablet Press machine (MTCM-I; GlobePharma, North Brunswick, NJ, USA) using a round, concave 12 mm caplet punch and compressed at 2200 N 21,22…”

“…The time taken by dosage form to rise to the surface and float on the media is called FLT, whereas TFT is the maximum duration of time that the dosage form stays floating on the medium surface 21. TFT and FLT were measured when the tablets were inserted into a beaker containing 500 mL of simulated gastric fluid (pH 1.2) kept at 37°C.…”

Formulation and evaluation of glipizide tablets utilizing Hibiscus rosasinensis leaves mucilage

“…Gums are produced either by causing injury to the plants or due to some pathological condition. Mucilages are considered to be physiological and normal products of metabolism (Razavi et al, 2014). Naturally occurring mucilages are used extensively these days due to their biodegradable nature, safety, availability and economical.…”