Hydrogel: Preparation, Characterization and Applications

sahu, nandini; Gupta, Diksha; Nautiyal, Ujjwal

doi:10.46811/apjnh/3.1.2

Cited by 13 publications

(7 citation statements)

References 14 publications

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“…Continued research and development in this field aim to optimize hydrogel formulations, enhance their regenerative potential, and ultimately improve patient outcomes in cartilage repair. 57,58 Various natural and synthetic polymers as well as different composites are used to produce cartilage repair hydrogels (Table 1).…”

Section: Magnetic Hydrogelmentioning

confidence: 99%

“…By mimicking the native cartilage environment, providing structural support, delivering bioactive molecules, and exhibiting desirable mechanical properties, hydrogels offer a promising solution for addressing cartilage injuries and degenerative diseases. Continued research and development in this field aim to optimize hydrogel formulations, enhance their regenerative potential, and ultimately improve patient outcomes in cartilage repair 57,58 …”

Section: Magnetic Hydrogelmentioning

confidence: 99%

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Magnetic hydrogel applications in articular cartilage tissue engineering

Taghizadeh,

Tayebi,

Akbarzadeh

et al. 2023

J Biomedical Materials Res

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Articular cartilage defects afflict millions of individuals worldwide, presenting a significant challenge due to the tissue's limited self‐repair capability and anisotropic nature. Hydrogel‐based biomaterials have emerged as promising candidates for scaffold production in artificial cartilage construction, owing to their water‐rich composition, biocompatibility, and tunable properties. Nevertheless, conventional hydrogels typically lack the anisotropic structure inherent to natural cartilage, impeding their clinical and preclinical applications. Recent advancements in tissue engineering (TE) have introduced magnetically responsive hydrogels, a type of intelligent hydrogel that can be remotely controlled using an external magnetic field. These innovative materials offer a means to create the desired anisotropic architecture required for successful cartilage TE. In this review, we first explore conventional techniques employed for cartilage repair and subsequently delve into recent breakthroughs in the application and utilization of magnetic hydrogels across various aspects of articular cartilage TE.

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Section: Magnetic Hydrogelmentioning

confidence: 99%

Section: Magnetic Hydrogelmentioning

confidence: 99%

Magnetic hydrogel applications in articular cartilage tissue engineering

Taghizadeh,

Tayebi,

Akbarzadeh

et al. 2023

J Biomedical Materials Res

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“…Incorporating such technologies may significantly enhance the success of ecological restoration efforts by providing shade and protective cover to optimize plant growth, reduce evapotranspiration rates, and extend water access periods [5,[24][25][26][27]. In addition, Hydrogel, a polymer matrix able to absorb several times its mass in water [27,28], can play a pivotal role in increasing plant water availability and resilience, as shown by previous research in the Galapagos Islands [25,29,30].…”

Section: Introductionmentioning

confidence: 99%

Assessing Water-Saving Technologies and the Impact of Giant Tortoise Herbivory on the Restoration of Opuntia megasperma var. orientalis on Española Island—Galapagos

Cevallos,

Jaramillo Díaz

2024

Water

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The prickly pear (Opuntia megasperma var. orientalis), a pivotal species for the ecological balance of Española Island in Galapagos, has witnessed a severe decline in its population due to the enduring presence of introduced feral goats over several decades. Additionally, the inherent slow recovery of this species, requiring several years of development, has contributed to its population decline. Several attempts were carried out to restore this species, but they were not successful due to the island’s extreme arid conditions. Subsequently, innovative water-saving technologies were introduced to ensure the survival and growth of the Opuntia species. Two water-saving technologies, Groasis Waterboxx® and Hydrogel, were applied in two distinct treatments, the first involving Waterboxx solely, and the second combining Waterboxx with Hydrogel, alongside a control group. Planting involved two types of cacti: cladodes and seedlings. To safeguard against potential damage from giant tortoises and local birds, protective mesh fencing was installed around the plants. Each monitoring session recorded plant survival and growth, evaluating the impact of water-saving technologies on cactus survival, maximum plant height reached, age at the time of plant death, and growth achieved since planting. Additionally, the study assessed the influence of climate on plant survival and growth. Unfortunately, the employment of protective mesh fences and Waterboxx containers resulted in the unintended loss of specific bird species. Consequently, a decision was taken to remove these protective measures, resulting in a substantial rise in herbivorous activity, and the subsequent mortality of nearly all plants. Our findings underscore the efficacy of water-saving technologies in Opuntia restoration. However, successful application necessitates a better understanding of these technologies within the unique conditions of the island. Future endeavors should focus on refining these techniques to minimize avian mortality while fostering biodiversity and restoring ecological equilibrium.

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“…It is biocompatible and biodegradable as well. This system provides optimal release and to maintains the minimum threshold level [17].…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Apocynin Loaded pH-sensitive Nanoparticle Based Hydrogel for the Management of Rheumatoid Arthritis

Akbar,

Khan,

Sabir

et al. 2023

Preprint

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The aim of the current study was to develop and evaluate the therapeutic potential of apocynin (APO) loaded pH-sensitive nanoparticles (NPs) based transdermal hydrogel for management of rheumatoid arthritis (RA). Slightly modified nanoprecipitation technique was used for preparation of polymeric nanoparticles. Optimization was done through design expert software. Optimized APO-NPs were loaded into carbopol-934 based hydrogel as final dosage form and further studied for physicochemical properties. Optimized APO-NPs formulation had a minimum particle size 63.44 nm, polydisperibility index 0.161, and zeta potential -15mV with a maximum encapsulation efficiency of 89%. In-vitro and ex-vivo studies of APO-NPs based hydrogel was performed at pH 5.5 (pH of normal skin) and 6.8 (pH of inflammed joint) showed a pH-responsive sustained drug release and increased penetration in comparison to free APO based hydrogel. The stability studies of APO-NPs based hydrogel were done to strengthen the potential use of the prepared formulation through transdermal route. Assessment and therapeutic efficacy of the prepared pH-sensitive nanocarriers system was evaluated in chronic inflammatory RA mice model. Parameters associated with chronic inflammation were investigated including behavioral changes and histopathological, and radiological x-rays images of joints of mice paws. In-vivo study depicts improvement in behavioral parameter, decline in synovial hyperplasia and bone structure restoration. In conclusion, APO loaded pH-sensitive NPs based transdermal is a promising carrier system that can effectively manage RA.

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Hydrogel: Preparation, Characterization and Applications

Cited by 13 publications

References 14 publications

Magnetic hydrogel applications in articular cartilage tissue engineering

Magnetic hydrogel applications in articular cartilage tissue engineering

Assessing Water-Saving Technologies and the Impact of Giant Tortoise Herbivory on the Restoration of Opuntia megasperma var. orientalis on Española Island—Galapagos

Development and Evaluation of Apocynin Loaded pH-sensitive Nanoparticle Based Hydrogel for the Management of Rheumatoid Arthritis

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