Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Su, Juanjuan; Li, Jiankang; Liang, Jiaheng; Zhang, Kun

doi:10.3390/life11101016

Cited by 154 publications

(132 citation statements)

References 179 publications

(199 reference statements)

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“…The effect of cross-linking determines the physical and chemical properties and functions of the hydrogel. Crosslinking is the most critical step in preparing hydrogel to hold the 3D structure and improve hydrogels’ physical and mechanical properties [ 54 ]. Table 2 summarizes the preparation method of hydrogel with its advantages and limitations.…”

Section: Hydrogelsmentioning

confidence: 99%

Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective

et al. 2022

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Advanced hybrid component development in nanotechnology provides superior functionality in the application of scientific knowledge for the drug delivery industry. The purpose of this paper is to review important nanohybrid perspectives in drug delivery between nanostructured lipid carriers (NLC) and hydrogel systems. The hybrid system may result in the enhancement of each component’s synergistic properties in the mechanical strength of the hydrogel and concomitantly decrease aggregation of the NLC. The significant progress in nanostructured lipid carriers–hydrogels is reviewed here, with an emphasis on their preparation, potential applications, advantages, and underlying issues associated with these exciting materials.

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Section: Hydrogelsmentioning

confidence: 99%

Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective

et al. 2022

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“…Nevertheless, the used crosslinkers for their synthesis are cytotoxic. Hence, recent studies have been focused on decreasing the toxicity caused by crosslinking agents, focusing on their replacement with more natural compounds such as citric acid (CA) [68].…”

Section: Types Of Hydrogels Used For Scaffold Developmentmentioning

confidence: 99%

“…Additionally, pNIPAM has good biocompatibility and biodegradability, non-toxicity, and exhibits physiological reactivity. The developed hydrogels have been extensively used for drug delivery and wound dressing [68].…”

Section: Types Of Hydrogels Used For Scaffold Developmentmentioning

confidence: 99%

New Insights of Scaffolds Based on Hydrogels in Tissue Engineering

et al. 2022

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In recent years, biomaterials development and characterization for new applications in regenerative medicine or controlled release represent one of the biggest challenges. Tissue engineering is one of the most intensively studied domain where hydrogels are considered optimum applications in the biomedical field. The delicate nature of hydrogels and their low mechanical strength limit their exploitation in tissue engineering. Hence, developing new, stronger, and more stable hydrogels with increased biocompatibility, is essential. However, both natural and synthetic polymers possess many limitations. Hydrogels based on natural polymers offer particularly high biocompatibility and biodegradability, low immunogenicity, excellent cytocompatibility, variable, and controllable solubility. At the same time, they have poor mechanical properties, high production costs, and low reproducibility. Synthetic polymers come to their aid through superior mechanical strength, high reproducibility, reduced costs, and the ability to regulate their composition to improve processes such as hydrolysis or biodegradation over variable periods. The development of hydrogels based on mixtures of synthetic and natural polymers can lead to the optimization of their properties to obtain ideal scaffolds. Also, incorporating different nanoparticles can improve the hydrogel’s stability and obtain several biological effects. In this regard, essential oils and drug molecules facilitate the desired biological effect or even produce a synergistic effect. This study’s main purpose is to establish the main properties needed to develop sustainable polymeric scaffolds. These scaffolds can be applied in tissue engineering to improve the tissue regeneration process without producing other side effects to the environment.

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“…In local drug delivery systems, hydrogel-based cancer therapy platforms have attracted much attention. Hydrogel is a network polymer formed by crosslinking gel monomers with soft texture, excellent biocompatibility, adjustable biochemical and biophysical properties [ 33 – 36 ]. There are many kinds of hydrogels with different synthesis methods to meet a variety of application requirements [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced postoperative cancer therapy by iron-based hydrogels

Zhang

et al. 2022

Biomater Res

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Surgical resection is a widely used method for the treatment of solid tumor cancers. However, the inhibition of tumor recurrence and metastasis are the main challenges of postoperative tumor therapy. Traditional intravenous or oral administration have poor chemotherapeutics bioavailability and undesirable systemic toxicity. Polymeric hydrogels with a three-dimensional network structure enable on-site delivery and controlled release of therapeutic drugs with reduced systemic toxicity and have been widely developed for postoperative adjuvant tumor therapy. Among them, because of the simple synthesis, good biocompatibility, biodegradability, injectability, and multifunctionality, iron-based hydrogels have received extensive attention. This review has summarized the general synthesis methods and construction principles of iron-based hydrogels, highlighted the latest progress of iron-based hydrogels in postoperative tumor therapy, including chemotherapy, photothermal therapy, photodynamic therapy, chemo-dynamic therapy, and magnetothermal-chemical combined therapy, etc. In addition, the challenges towards clinical application of iron-based hydrogels have also been discussed. This review is expected to show researchers broad perspectives of novel postoperative tumor therapy strategy and provide new ideas in the design and application of novel iron-based hydrogels to advance this sub field in cancer nanomedicine.

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Hydrogel Preparation Methods and Biomaterials for Wound Dressing

Cited by 154 publications

References 179 publications

Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective

Nanostructured Lipid Carriers-Hydrogels System for Drug Delivery: Nanohybrid Technology Perspective

New Insights of Scaffolds Based on Hydrogels in Tissue Engineering

Enhanced postoperative cancer therapy by iron-based hydrogels

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