Hydrogel systems for targeted cancer therapy

Abstract

When hydrogel materials with excellent biocompatibility and biodegradability are used as excellent new drug carriers in the treatment of cancer, they confer the following three advantages. First, hydrogel materials can be used as a precise and controlled drug release systems, which can continuously and sequentially release chemotherapeutic drugs, radionuclides, immunosuppressants, hyperthermia agents, phototherapy agents and other substances and are widely used in the treatment of cancer through radiotherapy, chemotherapy, immunotherapy, hyperthermia, photodynamic therapy and photothermal therapy. Second, hydrogel materials have multiple sizes and multiple delivery routes, which can be targeted to different locations and types of cancer. This greatly improves the targeting of drugs, thereby reducing the dose of drugs and improving treatment effectiveness. Finally, hydrogel can intelligently respond to environmental changes according to internal and external environmental stimuli so that anti-cancer active substances can be remotely controlled and released on demand. Combining the abovementioned advantages, hydrogel materials have transformed into a hit in the field of cancer treatment, bringing hope to further increase the survival rate and quality of life of patients with cancer.

Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

“…Whereas the former can suffer from low biocompatibility and nonspecific accumulation, 18 hydrogel-based systems offer a biocompatible drug delivery method for controlled and localized release that allows for minimized drug content and systemic toxicity. 19,20 Several macroscopic hydrogels�for in situ implantation/ injection or transdermal delivery�have been developed for improved chemotherapeutic efficacy. 21 In cases that bypass surgical intervention via in situ injection, researchers have relied on self-assembled or cross-linked polymer or polymerhybrid systems and have used targeting moieties and loaded immunotherapeutics to improve their efficacy.…”

“…These materials often take the form of nanoparticles or hydrogel-based systems. Whereas the former can suffer from low biocompatibility and nonspecific accumulation, hydrogel-based systems offer a biocompatible drug delivery method for controlled and localized release that allows for minimized drug content and systemic toxicity. , …”

Novel pH-Responsive CaO2@ZIF-67-HA-ADH Coating That Efficiently Enhances the Antimicrobial, Osteogenic, and Angiogenic Properties of Titanium Implants

“…19 It has been shown that grafting adipic acid dihydrazide (ADH) onto the carboxyl group of hyaluronic acid (HA) formed a coupled reagent (HA-ADH) with excellent biocompatibility and sensitive pH responsiveness. 20,21 Park JK et al 22 reported a composite film based on poly(lactic-co-glycolic acid) (PLGA), HA, and ADH. This film may be used as a periodontal barrier film to promote bone regeneration in patients with periodontitis due to its excellent biocompatibility and controlled biodegradability.…”

Intratumoral Lactate Depletion Based on Injectable Nanoparticles−Hydrogel Composite System Synergizes with Immunotherapy against Postablative Hepatocellular Carcinoma Recurrence

“…Moreover, biodegradable hydrogels have gained increasing recognition for their applications in cancer treatment. [ 29 ] Among them, thermosensitive hydrogels with sol–gel phase transition characteristics are particularly well‐suited as delivery platforms for achieving sustained release of therapeutic agents at localized sites. [ 30,31 ]…”

“…Moreover, biodegradable hy-drogels have gained increasing recognition for their applications in cancer treatment. [29] Among them, thermosensitive hydrogels with sol-gel phase transition characteristics are particularly wellsuited as delivery platforms for achieving sustained release of therapeutic agents at localized sites. [30,31] In this present study, we designed an injectable nanoparticles (NPs)-hydrogel composite system (designated as LOX-MnO 2 @Gel) for intratumoral catalytic depletion of lactate.…”