Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases (Adv. Mater. 16/2022)

Li, Zimeng; Li, Gang; Xu, Jiajia; Li, Chenwen; Han, Songling; Chun-fan, Zhang; Wu, Peng; Lin, Yongyao; Wang, Chenping; Zhang, Jianxiang; Li, Xiaodong

doi:10.1002/adma.202270119

Cited by 30 publications

(34 citation statements)

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“…2A). 52 To achieve this, they synthesized a pH-responsive multivalent hydrophobic host compound, AHCD, by conjugating b-CD to cyclic hexachlorocyclotriphosphazene (HCTP) and acetalization. Subsequently, they prepared pH-responsive ACPA NPs by nanoprecipitation of AHCD with Ad-modified 8-armed PEG, relying on weak hostguest interactions.…”

Section: Host-guest Interactionsmentioning

confidence: 99%

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Zhao,

Zheng,

et al. 2024

J. Mater. Chem. B

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Section: Host-guest Interactionsmentioning

confidence: 99%

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Zhao,

Zheng,

et al. 2024

J. Mater. Chem. B

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“…For example, Li et al developed a pH‐responsive PEG‐based composite hydrogel system that could respond to the periodontal inflammatory microenvironment (pH∼6.0). [ 91 ] Since the level of MMP8 in gingival crevicular fluid reflects the severity of periodontitis, MMP8 has been identified as a diagnostic factor for monitoring the progression of periodontitis. [ 92,93 ] Inspired by this, Guo et al.…”

Section: The Fabrication Of Hydrogelsmentioning

confidence: 99%

“…developed a functional dexamethasone‐containing hydrogel via transformable nanoparticles assembled by a pH‐responsive host cyclodextrin and a polymer guest. [ 91 ] In a rat periodontitis model, the nanoparticles could serve as nanovehicles of dexamethasone and transform into hydrogels in response to the acidic environment of periodontitis, which inhibited the expression of TNF‐α and IL‐6, as well as suppressed bone resorption and the formation of periodontal pockets.…”

Section: Bioactive Hydrogels For Periodontitis Treatmentmentioning

confidence: 99%

Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Yin

Yang

et al. 2023

Adv Funct Materials

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Periodontitis is a biofilm‐induced, host‐mediated inflammatory disease that results in periodontal tissue destruction. The design of functional biomaterials based on disease pathophysiology is essential for enhancing their therapeutic effects in periodontitis treatment. As promising localized drug delivery systems and tissue engineering scaffolds, hydrogels have gained significant interest for controlled and sustained release of bioactive agents in periodontal applications. The rational design of bioactive hydrogels can facilitate bacterial control and modulate destructive host inflammation, thereby preventing the progression of periodontitis. In this review, the pathophysiological mechanisms underlying periodontitis as fundamental principles for the design of functional hydrogel systems are first introduced. In the following part, an overview is systematically provided of the types and functions of the bioactive hydrogel systems loaded with anti‐bacterial and anti‐inflammatory agents for periodontal delivery. Finally, the remaining challenges and future perspectives of hydrogel delivery systems for periodontal applications are proposed. It is believed that this review will inspire the rational design and development of innovative functional hydrogel biomaterials toward periodontal therapy.

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“…Most recently, we developed multifunctional hydrogel through pH‐responsive transformation of NPs for arthritis treatment ( Figure 10 a). [ 198 ] To this end, pH‐responsive NPs were synthesized by self‐assembly of a polyvalent, hydrophobic, pH‐responsive CD host compound and a polyvalent hydrophilic guest macromolecule. These NPs exhibited pH‐responsive behaviors and could be hydrolyzed under acidic conditions, thereby releasing hydrophilic, polyvalent host compounds that spontaneously assemble with the polyvalent guest molecules through strengthened host–guest interactions, which in turn formed hydrogel.…”

Section: Therapeutic Applications Of Bioactive CD Material‐derived Na...mentioning

confidence: 99%

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

Li,

Chen,

et al. 2023

Advanced NanoBiomed Research

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Despite remarkable advances in understanding the mechanisms underlying inflammation, the currently available anti‐inflammatory therapies have many limitations, such as poor efficacies, low selectivity, and severe adverse effects. Bioactive materials with intrinsically anti‐inflammatory activities have emerged as promising drug candidates for the treatment of inflammatory disorders. Among them, nanotherapies based on bioactive cyclodextrin (CD) materials have attracted much attention, owing to their multiple advantages, including broad availability, well‐controlled structures, easy functionalization, good processibility, high cost‐effectiveness, and excellent biocompatibility. This review provides a comprehensive overview of the recent advancements in the development and applications of anti‐inflammatory nanoparticles (NPs) based on bioactive CD materials, with special focus on reactive oxygen species‐scavenging NPs and NPs capable of regulating inflammatory cell recruitment and activation. In addition, the applications of these anti‐inflammatory nanotherapies in the treatment of different acute/chronic inflammatory diseases are highlighted. Furthermore, major challenges in the clinical translation of these new generation anti‐inflammatory therapies derived from bioactive CD materials are discussed.

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Hydrogel Transformed from Nanoparticles for Prevention of Tissue Injury and Treatment of Inflammatory Diseases (Adv. Mater. 16/2022)

Cited by 30 publications

References 0 publications

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Rational Design of Bioactive Hydrogels toward Periodontal Delivery: From Pathophysiology to Therapeutic Applications

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

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