Hydrogels: An overview of its classifications, properties, and applications

Mehta, Preeti; Sharma, Monika; Devi, Meena

doi:10.1016/j.jmbbm.2023.106145

Cited by 34 publications

(14 citation statements)

References 199 publications

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“…The polymer chains resemble the natural ECM and provide attachment sites for cells. All these characteristics closely mimic natural tissues and biopolymers make hydrogels biocompatible ( Ho et al, 2022 ; Zhou et al, 2022 ; Metha et al, 2023 ).…”

Section: 3d Bioprinting With Hydrogelsmentioning

confidence: 87%

“…Higher cross-linking density leads to decreased mesh size or porosity with increased stiffness. The polymer chains in the hydrogel bioink resemble the natural ECM and the swelled hydrogel provides attachment sites for cells (Adapted from Berger et al, 2004 ; Mehta et al, 2023 ; Sinko, 2011 ; Xu J et al, 2022a ). Created with BioRender.com .…”

Section: 3d Bioprinting With Hydrogelsmentioning

confidence: 99%

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The influence of viscosity of hydrogels on the spreading and migration of cells in 3D bioprinted skin cancer models

Du Plessis,

Gouws,

Nieto

2024

Front. Cell Dev. Biol.

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Various in vitro three-dimensional (3D) tissue culture models of human and diseased skin exist. Nevertheless, there is still room for the development and improvement of 3D bioprinted skin cancer models. The need for reproducible bioprinting methods, cell samples, biomaterial inks, and bioinks is becoming increasingly important. The influence of the viscosity of hydrogels on the spreading and migration of most types of cancer cells is well studied. There are however limited studies on the influence of viscosity on the spreading and migration of cells in 3D bioprinted skin cancer models. In this review, we will outline the importance of studying the various types of skin cancers by using 3D cell culture models. We will provide an overview of the advantages and disadvantages of the various 3D bioprinting technologies. We will emphasize how the viscosity of hydrogels relates to the spreading and migration of cancer cells. Lastly, we will give an overview of the specific studies on cell migration and spreading in 3D bioprinted skin cancer models.

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Section: 3d Bioprinting With Hydrogelsmentioning

confidence: 87%

Section: 3d Bioprinting With Hydrogelsmentioning

confidence: 99%

The influence of viscosity of hydrogels on the spreading and migration of cells in 3D bioprinted skin cancer models

Du Plessis,

Gouws,

Nieto

2024

Front. Cell Dev. Biol.

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“…Hydrogels are three-dimensional cross-linked polymer networks that are known for their ability to uptake large amounts of water. − This hydrophilic nature is advantageous for dewatering applications, as it increases the permeation of water and decreases fouling of the membrane surface. In addition, their porous structure allows for selective diffusion of hydrophilic solutes into the material, rendering hydrogels highly suitable for application in agriculture, pharmaceuticals, catalysis, separation technology, biotechnology, and wastewater treatment. , In fact, they have already been successfully produced at an industrial scale for some application fields, evident by the commercialization of hydrogel-containing contact lenses, wound dressings, and disposable diapers . By tuning the chemical properties, hydrogels can also be made responsive to various stimuli, such as redox chemistry, temperature, pH, and electric field. ,− This stimuli-responsive nature may be useful to regulate the permeate flux and selectivity on-demand, as well as enabling the reuse of hydrogel draw agents .…”

Section: Advances In Membrane Dewateringmentioning

confidence: 99%

“… 186 , 187 In fact, they have already been successfully produced at an industrial scale for some application fields, evident by the commercialization of hydrogel-containing contact lenses, wound dressings, and disposable diapers. 188 By tuning the chemical properties, hydrogels can also be made responsive to various stimuli, such as redox chemistry, temperature, pH, and electric field. 181 , 189 − 191 This stimuli-responsive nature may be useful to regulate the permeate flux and selectivity on-demand, 185 as well as enabling the reuse of hydrogel draw agents.…”

Section: Advances In Membrane Dewateringmentioning

confidence: 99%

Advances in Membrane Separation for Biomaterial Dewatering

Diepenbroek,

Mehta,

Borneman

et al. 2024

Langmuir

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Biomaterials often contain large quantities of water (50−98%), and with the current transition to a more biobased economy, drying these materials will become increasingly important. Contrary to the standard, thermodynamically inefficient chemical and thermal drying methods, dewatering by membrane separation will provide a sustainable and efficient alternative. However, biomaterials can easily foul membrane surfaces, which is detrimental to the performance of current membrane separations. Improving the antifouling properties of such membranes is a key challenge. Other recent research has been dedicated to enhancing the permeate flux and selectivity. In this review, we present a comprehensive overview of the design requirements for and recent advances in dewatering of biomaterials using membranes. These recent developments offer a viable solution to the challenges of fouling and suboptimal performances. We focus on two emerging development strategies, which are the use of electric-field-assisted dewatering and surface functionalizations, in particular with hydrogels. Our overview concludes with a critical mention of the remaining challenges and possible research directions within these subfields.

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“…antigen, glucose, enzyme responsive) responsive based on the stimuli-responsiveness; (vii) crystalline and amorphous based on the crystallinity of network and; (vii) degradable and non-degradable based on the degradability of network. [37][38][39] Additionally, hydrogels may also be categorized and sub-categorized into different classes depending on particular character and application elds.…”

Section: Classication and Chemistrymentioning

confidence: 99%