Hydrogels for Tissue Engineering and Delivery of Tissue-Inducing Substances

Insight into hydrogels

“…Hydrogels can be synthesized in a various physical forms, including micro particles, nanoparticles, slabs, coatings, and films. [14][15][16] Hydrogels are water swollen polymeric matrices with three-dimensional configuration capable of absorbing high amounts of water or other biological fluids. Their tendency to swell, under physiological environment, makes them an intelligent and ideal material for biomedical applications.…”

“…So, due to this reason, either temperature responsive or pH responsive hydrogels can be formulated and used for the controlled and site-specific drug delivery. [46] Hydrogels drug delivery has a wide range of applications in clinical practice and biomedical fields such as materials for contact lenses in tissue engineering, regenerative medicine, biosensors, and separation of biomolecules or matrices for cell-encapsulation and tools for the controlled and sustained release of bioactive agents and proteins due to their ability to fabricate in various physical forms. [16,[47][48][49] Drug delivery through hydrogels has gained a wide area of interest because of the ability to protect the bioactive agents from numerous hostile conditions such as low pH in the acidic environment of stomach and the presence of enzymes.…”

Selective comparison of gelling agents as neural cell culture matrices for long-term microelectrode array electrophysiology

“…Due to their softness and 3D meshwork, cells can engage in a more tissue-mimetic cell-matrix interaction. Apart from their biomedical use (e.g., contact lenses, wound dressings, drug delivery devices (Caló and Khutoryanskiy, 2015)), hydrogels have found their way into cell culture labs (Altmann et al, 2009;Andersen et al, 2015;Tibbitt and Anseth, 2009) and tissue engineering (Baroli, 2007;Kim et al, 2011;Leal-Egaña et al, 2013;Hunt et al, 2014). In the latter context, they serve as circuit reconstruction scaffolds for the timed orchestration of events in (neuro)development, as drug delivery devices or as cell encapsulation constituents for implantation (Aurand et al, 2012a(Aurand et al, , 2012bCarballo-Molina and Velasco, 2015;McMurtrey, 2015).…”

Hydrogels from Chitosan and a Novel Copolymer Poly(<i>N</i>-Vinyl-2-Pyrrolidone-<i>Co</i>-Acrolein)

“…Throughout the last five decades numerous publications on this research topic have been released. Hydrogels play an important role in tissue engineering [2][3][4][5], dressings for burn wounds and other kinds of injuries [6,7], "intelligent" hidrogels for drug controlled release [8,9], and other biomedical applications [10].…”