Hydrogels in endovascular embolization. II. Clinical use of spherical particles

Horák, Daniel; Švec, František; Kálal, J.; Adamyan, A. A.; Volynskii, Y D; Воронкова, О. С.; Коков, Л. С.; Гумаргалиева, К. З.

doi:10.1016/0142-9612(86)90037-2

Cited by 36 publications

(14 citation statements)

References 2 publications

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“…They have been found to be useful in the controlled release of drugs, for immobilization of enzymes, for immunochemical studies, for the propagation of mammalian cells in culture, for coating vascular stents for producing endovascular grafts and in gel permeation chromatography [11]. In recent years, hydrogel particles based on poly(2-hydroxyethyl methacrylate) (PHEMA) have been found to be useful as an embolization agent [12]. We have recently reported on a novel suspension polymerization technique for the preparation of highly porous PHEMA microspheres of wide size range using polymeric porogens [13] which are succeptible to derivatization to a very significant extent due to their high porosity [14], which may also find application as particulate emboli.…”

Section: Resultsmentioning

confidence: 99%

Endovascular embolization using hydrogel microspheres

Jayakrishnan

Mohanty

Rao

et al. 1994

J Mater Sci: Mater Med

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Controlled alkaline hydrolysis of crosslinked poly(methyl methacrylate) (PMMA) microspheres produced highly hydrophilic, smooth, compressible, nearly perfect microspheres having a range of water content 40-95%. These particles were found to possess many desirable properties as a material for therapeutic embolization. After successful toxicological and animal evaluation, these particles were used to treat various ailments such as arteriovenous malformations (AVM) of the brain, spinal cord, limbs, face and trunks, preoperative devascularization of tumours and in the management of severe life-threatening haemoptysis and haematemesis in clinical trials involving over 90 patients at this Institute. The results of these studies appeared to be very encouraging. The material is found to be an ideal embolic agent in all these clinical situations.

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Section: Resultsmentioning

confidence: 99%

Endovascular embolization using hydrogel microspheres

Jayakrishnan

Mohanty

Rao

et al. 1994

J Mater Sci: Mater Med

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“…Many scientists have been interested in porous particles with a permanent well‐defined porous structure for a wide range of applications, such as ion exchange resins and sorbents, catalyst supports, and materials for biomedical applications . The size, shape, size distribution, and pore size (and distribution) of the porous particle are vital in these applications.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Asymmetric Porous Janus Particles Using Microfluidics and Directional UV Curing

Kim

Joo

Park

2013

Part & Part Syst Charact

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Asymmetric porous Janus particles of poly(tripropylene glycol diacrylate) poly(TPGDA)) are prepared from TPGDA/4‐cyano‐4′‐pentylbiphenyl (5CB) mixtures using microfluidics and directional ultraviolet (UV) curing. Droplets of the TPGDA/5CB mixtures, which have been prepared successfully in the microfluidics channel, are photo‐polymerized in the off‐chip reservoir with a focused UV beam irradiated from beneath the reservoir. The isotropic TPGDA/5CB single phase is phase‐separated into two phases during the photopolymerization of TPGDA. The relative rate of photopolymerization compared with phase separation is different according to which hemisphere of the droplet is exposed to the UV beam. Rapid polymerization on the UV‐exposed hemisphere of the droplet produces small 5CB‐rich phase‐separated domains leading to a close and smooth structure, whereas slow polymerization on the opposite hemisphere produces large 5CB‐rich domains that induce an open and rough porous structure. These asymmetric porous Janus particles of poly(TPGDA) cause asymmetric swelling, in which the UV‐exposed hemisphere swell more than the other in the solvents due to the large porous surface area made by the small‐phase‐separated domain, which prevents the formation of a compact cross‐linked network structure. The complete dried droplet after the extraction of 5CB has an acorn‐like appearance, in which the swelled UV‐exposed hemisphere shrinks more than the other leading to a wrinkled structure. This new method combining microfluidics and directional UV curing provides a simple and unique way of fabricating asymmetric porous Janus particles and their functionalization with metal nanoparticles.

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“…The hydroxyl group in poly(2-hydroxyethyl methacrylate) (PHEMA) can be derivatized to produce a wide range of polymeric reagents suited to pharmaceutical and chromatographic applications as well as to immobilize biopolymers (enzymes, antibodies, cells), encapsulate mammalian cells and other sensitive compounds [1][2][3][4][5][6][7][8]. Transparent PHEMA, prepared by bulk polymerization, forms gels by entrapping water or other liquids.…”

Section: Introductionmentioning

confidence: 99%

Gel formation in frontal polymerization of 2-hydroxyethyl methacrylate

et al. 2004

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Frontal polymerization of 2-hydroxyethyl methacrylate was investigated to study the effect of type and concentration of initiator, solvent and diluent on the existence of a front, on front velocity as well as front temperature. A significant effect of the type of initiator and its concentration was recorded. Poly(2-hydroxyethyl methacrylate) (PHEMA) was obtained predominantly as a gel. The different gels were evaluated for water and cyclohexane gain and porosity, and the mechanism of gel formation is discussed. Amongst the three diluents used (silica gel, β-cyclodextrin and silica sol), gel formation was highest in the presence of silica sol (≈ 42%). Pore dimensions were less than 15 nm and pore size distribution was narrow. PHEMA networks showed significantly higher water regain due to swelling than attributed to the pore volume as estimated by mercury porosimetry or cyclohexane regain. Kinetics of the equilibrium swelling ratio was studied.

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Hydrogels in endovascular embolization. II. Clinical use of spherical particles

Cited by 36 publications

References 2 publications

Endovascular embolization using hydrogel microspheres

Endovascular embolization using hydrogel microspheres

Preparation of Asymmetric Porous Janus Particles Using Microfluidics and Directional UV Curing

Gel formation in frontal polymerization of 2-hydroxyethyl methacrylate

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