Hydrogels: Mechanochemical Adhesion and Plasticity in Multifiber Hydrogel Networks (Adv. Mater. 8/2020)

Ban, Ehsan; Schoonen, Anna C. M.; Lee, Mu‐Huan; D’Este, Matteo; Shenoy, Vivek B.; Burdick, Jason A.

doi:10.1002/adma.202070061

Cited by 5 publications

(5 citation statements)

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“…[44] This functional OHA with active carbonyl groups can create acidic-labile hydrazone bonds or imide bonds with therapeutic agents or other polymers through Schiff-base reaction under a mild condition. [45,46] Grafted antibodies or enzymes can preserve their biological activities. Notably, it has been demonstrated that OHA performs the potentials to construct injectable hydrogel.…”

Section: Oxidized Ha (Oha)mentioning

confidence: 99%

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Luo,

Wang,

et al. 2023

Adv Funct Materials

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Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, and highly designable capacity, HA hydrogels have been an emerging biomaterial, showing tailoring performance in terms of chemical modifications and hydrogel forms. Various preparation technologies have been developed for the fabrication of the tailoring HA hydrogels with unique structures and functions. They have been utilized in diverse biomedical applications like drug delivery and tissue engineering scaffolds. Herein, this review comprehensively summarizes the HA derivatives with different molecule weights and functional modifications. Then the various fabrication methods to obtain tailoring hydrogels in the forms of nanogel, nanofiber, microparticle, microneedle patch, injectable hydrogel, and scaffold are reviewed as well. The emphasis is focused on the shining biomedical applications of these tailoring HA hydrogels in anti‐bacteria, anti‐inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis treatment, diagnosis, etc. The potentials and prospects are subsequently given to inspire further investigation, aiming at accelerating product translation from research to clinic.

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Section: Oxidized Ha (Oha)mentioning

confidence: 99%

Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Luo,

Wang,

et al. 2023

Adv Funct Materials

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“…Highly functionalized monomers, such as methacrylated gelatin (GelMA), functionalized hyaluronic acid, and alginate have been used to fabricate hydrogel nanofibers without extra crosslinker. [ 58–62 ] Nanofibers composed of methacrylated poly(vinyl alcohol) and malleated hyaluronate could form crosslinking under UV to form nanofibrous hydrogels with high water contents. By simultaneous electrospinning and photo‐polymerization, double network agarose/PAAm nanofiber hydrogels were fabricated, resulting in the enhancement of strength and thermal stability.…”

Section: Conductive Electrospun Nanofibersmentioning

confidence: 99%

Electrospinning Nanofibers as Stretchable Sensors for Wearable Devices

Zhu,

Zheng,

2023

Macromolecular Bioscience

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Wearable devices attract great attention in intelligent medicine, electronic skin, artificial intelligence robots, and so on. However, boundedness of traditional sensors based on rigid materials unconstrained self‐multilayer structure assembly and dense substrate in stretchability and permeability limits their applications. The network structure of the elastomeric nanofibers gives them excellent air permeability and stretchability. By introducing metal nanofillers, intrinsic conductive polymers, carbon materials, and other methods to construct conductive paths, stretchable conductors can be effectively prepared by elastomeric nanofibers, showing great potential in the field of flexible sensors. This perspective briefly introduces the representative preparations of conductive thermoplastic polyurethane, nylon, and hydrogel nanofibers by electrospinning and the application of integrated electronic devices in biological signal detection. The main challenge is to unify the stretchability and conductivity of the fiber structure.

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“…In 2020, an interesting combination of reactive chemistries has been proposed by integrating reactive units within func-tional block copolymers for in situ UV ES as well as complementarily reactive groups for covalent cross-linking. 205 Two separate solutions of HA modified with norbornenes exclusively functionalized with hydrazides and aldehydes were oppositely spun at the same time on a rotating mandrel (Fig. 11c).…”

Section: Reactive Electrospinning Designsmentioning

confidence: 99%

“…255 A new concept in the field of reactive ES for tissue engineering has been proposed by Davidson et al, where fiber-to-fiber cross-linking could be triggered by mechanical loading, therewith mimicking the force-responsive properties of the extra-cellular matrix. 205 To achieve this novel mechano-sensitive hydrogel, they have utilized hyaluronic acid as a functional polymer for the selective attachment of aldehyde or hydrazide units. Aldehyde functionalities in polysaccharides can be easily obtained by oxidizing the glucoside ring with sodium periodate as previously discussed (see section 4.2.1), whereas hydrazine moieties were introduced by reacting to the carboxylic groups in hyaluronic acid with adipic dihydrazide.…”

Section: In Situ Photo-induced Cross-linkingmentioning

confidence: 99%