Hydrogels toughened by biominerals providing energy-dissipative sacrificial bonds

Fukao, Kazuki; Tanaka, Kazuki; Kiyama, Ryuji; Nonoyama, Takayuki; Gong, Jian Ping

doi:10.1039/d0tb00833h

Cited by 35 publications

(38 citation statements)

References 20 publications

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“…The above results provided a strong evidence for that the nano-HA had a positive effect on the tissue adhesion strength of the hydrogels. The adhesion enhancement effect of nanoparticles could be attributed to the following four aspects: First, the nano-HA could be adsorbed to the surface of the tissue and broken under the action of the gel network conduction force, which consumed a lot of energy to inhibit the propagation and growth of cracks; [48,49] Second, the platelet nanoparticles used in this experiment had a significant enhancement of adhesion over spherical and cylindrical nanoparticles, owing to the much higher surface-to-volume ratio and the easier interaction with the interfaces; [50] Third, the incorporation of nanoparticles to the hydrogel effectively reduced its penetration into the tissue and made cohesiveness increase to some extent. [51,52] This was substantiated by the fact that the addition of nano-HA caused a large increase in E′ and tan (Figure S7a,b, Supporting Information), which meant that a higher activation energy for the breaking of cross-links was needed; Fourth, the adsorption of PAA chains on big nano-HA particles presumably mainly produced a "mushroom" region consisting of a sparse number of extended loops or tails, resulting in better adhesion.…”

Section: Tissue Adhesive Strengthmentioning

confidence: 99%

Enhancing Tissue Adhesion and Osteoblastic Differentiation of MC3T3‐E1 Cells on Poly(aryl ether ketone) by Chemically Anchored Hydroxyapatite Nanocomposite Hydrogel Coating

Liu

Pan

Cheng

et al. 2021

Macromolecular Bioscience

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Tissue adhesion to bone implant and osteoblastic differentiation are the key factors to achieve poly(aryl ether ketone) (PAEK) implant osseointegration. However, physical interaction of implant with tissue and hydroxyapatite coating suffers from slow implant tissue integration and lack of long-term stability. In this study, a novel poly(phthalazinone ether sulfone ketone) containing allyl groups (APPBAESK) is coated onto PPBESK sheet for reacting with the allyl groups of the hydrogel coating to enhance its stability. N-Succinimidyl (NHS)-ester activated group and nano-hydroxyapatite (nano-HA) are introduced into the hydrogel synthesized from gelatin methacrylate (GelMA) and acrylic acid to construct a nanocomposite hydrogel coating on PPBESK which is a promising PAEK implant material. The hydrophilicity of the PPBESK sheet is improved by the hydrogel coating. The chemical components of the nanocomposite hydrogel coating are confirmed by X-ray photoelectron spectroscope, Attenuated total reflection infrared, and X-ray powder diffraction. The tissue shear adhesion strength of the hydrogel coating toward pig skin is enhanced due to the synergism of NHS-ester activated group and nano-HA. The osteogenic differentiation of MC3T3-E1 preosteoblasts is promoted by nano-HA in nanocomposite hydrogel coating. Therefore, the bifunctional nanocomposite hydrogel coating provides a great application prospect in the surface modification of PAEK implants in bone tissue engineering.

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Section: Tissue Adhesive Strengthmentioning

confidence: 99%

Enhancing Tissue Adhesion and Osteoblastic Differentiation of MC3T3‐E1 Cells on Poly(aryl ether ketone) by Chemically Anchored Hydroxyapatite Nanocomposite Hydrogel Coating

Liu

Pan

Cheng

et al. 2021

Macromolecular Bioscience

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“…As mentioned, Double network (DN) gels show higher toughness by sacrificial fracture of the brittle network and weak physical bonds, dissipating energy, whereas the covalent network holds the whole structure. This concept can be broadened, changing the weaker and brittle polymeric network by ceramics and minerals such phosphate salt or hydroxyapatite [276]. In addition, PAA has been used to strengthen PVA by simply soaking PVA hydrogels obtained by the typical freezing-thawing method in PAA solutions.…”

Section: Poly-acrylic Acid (Paa) and Sodium Polyacrylate (Pana)mentioning

confidence: 99%

A Review of the Use of GPEs in Zinc-Based Batteries. A Step Closer to Wearable Electronic Gadgets and Smart Textiles

2020

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With the flourish of flexible and wearable electronics gadgets, the need for flexible power sources has become essential. The growth of this increasingly diverse range of devices boosted the necessity to develop materials for such flexible power sources such as secondary batteries, fuel cells, supercapacitors, sensors, dye-sensitized solar cells, etc. In that context, comprehensives studies on flexible conversion and energy storage devices have been released for other technologies such Li-ion standing out the importance of the research done lately in GPEs (gel polymer electrolytes) for energy conversion and storage. However, flexible zinc batteries have not received the attention they deserve within the flexible batteries field, which are destined to be one of the high rank players in the wearable devices future market. This review presents an extensive overview of the most notable or prominent gel polymeric materials, including biobased polymers, and zinc chemistries as well as its practical or functional implementation in flexible wearable devices. The ultimate aim is to highlight zinc-based batteries as power sources to fill a segment of the world flexible batteries future market.

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“…The technique is by mineralizing low-crystalline HAp nanoparticles with ≈600 nm diameter to the surface layer of the semipermeable DN hydrogel. [11][12][13][14][15] When HAp-hybridized DN gel is implanted in a defect created in bones, the HAp induces osteogenesis penetrating into the gel matrix, which forms the strong bonding of the DN gel to bone within 4 weeks. On the other hand, the pristine DN gel without HAp-hybridization did not show any bonding to bone at all even after 12 weeks implantation.…”

Section: Doi: 101002/adhm202001731mentioning

confidence: 99%

Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone

Nonoyama

Wang

Tsuda

et al. 2020

Adv Healthcare Materials

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Tough double network (DN) hydrogels are promising substitutes of soft supporting tissues such as cartilage and ligaments. For such applications, it is indispensable to robustly fix the hydrogels to bones with medically feasible methods. Recently, robustly bonding the DN hydrogels to defected bones of rabbits in vivo has been proved successful. The low crystalline hydroxyapatite (HAp) of calcium‐phosphate‐hydroxide salt coated on the surface layer of the DN hydrogels induced spontaneous osteogenesis penetrating into the semi‐permeable hydrogels to form a gel/bone composite layer. In this work, the 44Ca isotope‐doped HAp/DN hydrogel is implanted in a defect of rabbit femoral bone and the dynamic osteogenesis process at the gel/bone interface is analyzed by tracing the calcium isotope ratio using isotope microscopy. The synthetic HAp hybridized on the surface layer of DN gel dissolves rapidly in the first two weeks by inflammation, and then the immature bone with a gradient structure starts to form in the gel region, reutilizing the dissolved Ca ions. These results reveal, for the first time, that synthetic HAp is reutilized for osteogenesis. These facts help to understand the lifetime of bone absorbable materials and to elucidate the mechanism of spontaneous, non‐toxic, but strong fixation of hydrogels to bones.

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Hydrogels toughened by biominerals providing energy-dissipative sacrificial bonds

Abstract: Inspired from toughening mechanism of bone tissues, hydrogels, toughened by low crsytalline hydroxyapatite as sacrificial bonds, were created.

Cited by 35 publications

References 20 publications

Enhancing Tissue Adhesion and Osteoblastic Differentiation of MC3T3‐E1 Cells on Poly(aryl ether ketone) by Chemically Anchored Hydroxyapatite Nanocomposite Hydrogel Coating

Enhancing Tissue Adhesion and Osteoblastic Differentiation of MC3T3‐E1 Cells on Poly(aryl ether ketone) by Chemically Anchored Hydroxyapatite Nanocomposite Hydrogel Coating

A Review of the Use of GPEs in Zinc-Based Batteries. A Step Closer to Wearable Electronic Gadgets and Smart Textiles

Isotope Microscopic Observation of Osteogenesis Process Forming Robust Bonding of Double Network Hydrogel to Bone

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