Hydrogen as a Selective Antioxidant: A Review of Clinical and Experimental Studies

Abstract

Oxidative stress is implicated in the pathogenesis of many diseases; however, currently used antioxidants have a high toxicity that constrains administration to a narrow window of therapeutic dosage. There is a clear need for more effective and safer antioxidants. Diatomic hydrogen (H 2 ) was proposed as a novel antioxidant that selectively reduces levels of toxic reactive-oxygen species. Recently, many studies have reported that H 2 (inhaled or orally ingested, typically as approximately 0.8 mM H 2 -saturated water), can exert beneficial effects in diverse animal models of ischaemia-reperfusion injury, and inflammatory and neurological disease. In the clinic, oral administration of H 2 -saturated water is reported to improve lipid and glucose metabolism in subjects with diabetes or impaired glucose tolerance; promising results have also been obtained in reducing inflammation in haemodialysis patients and treating metabolic syndrome. These studies suggest H 2 has selective antioxidant properties, and can exert antiapoptotic, antiinflammatory and antiallergy effects. This review summarizes recent research findings and mechanisms concerning the therapeutic potential of H 2 .

Influence of redox potential of different water quality on the human blood

“…Balance of redox regulation system is normalized using antioxidants. Strong antioxidant is water with a negative RP value [3,7].…”

Can hydrogen retard the progression of osteoarthritis?

“…In a vitro research, hydrogen would not eliminate physiological superoxide anion and hydrogen peroxide, both of which play physiological roles to kill some types of bacteria along with neutrophils and macrophages (Ohsawa et al, 2007). Indeed, hydrogen does not influence physiological parameters, such as temperature, blood pressure, pH or pO 2 (Hong et al, 2010). Thirdly, the product of hydrogen reacting with hydroxyl radicals is water, which is harmless to body and need no further decomposition when compared with vitamin C and E (Niki, 1987).…”

Resonance electron attachment to natural polyphenolic compounds and their biological activity

“…Схематическое изображение и энергии первых четырёх вакантных МО π-типа в ресвератроле и пицеатанноле по данным расчёта методом B3LYP/6-31G(d) и масштабирования. мунной системы и имеет широчайший спектр полезного действия на организм [40];…”