Hydrogen bond donor and alcohol chain length effect on the physicochemical properties of choline chloride based deep eutectic solvents mixed with alcohols

Cotroneo-Figueroa, Vincenzo P.; Gajardo‐Parra, Nicolás F.; López‐Porfiri, Pablo; Leiva, Ángel; González‐Miquel, María; Garrido, José Matías; Canales, Roberto I.

doi:10.1016/j.molliq.2021.116986

Cited by 50 publications

(28 citation statements)

References 73 publications

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“…Based on the analysis of published values of DES viscosity, where the water content is stated, it is at the moment unclear by how much water content present in the current measurements (0.029–0.079 wt %) lowers the viscosity. Our own measurements , indicate that no trend in viscosity is observable, within the estimated uncertainty, for the three measured DESs (DES-A2, DES-C1, and DES-D1) in the range of water content (0.018–0.092 wt %). Analyses of other data carried out in this work (see the Density and Viscosity Measurements section) also support this conclusion.…”

Section: Methodsmentioning

confidence: 58%

Viscosity of Choline Chloride-Based Deep Eutectic Solvents: Experiments and Modeling

et al. 2020

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Deep eutectic solvents (DES) have emerged as promising 'green' solvents, but their successful industrial application requires relatively low viscosity. DES prepared from choline chloride and glycols offer such possibility. Viscosity and density are reported for a number of DES obtained by mixing choline chloride and a glycol (ethylene glycol, 1,2-propanediol, 1,3-propanediol, and 1,4-butanediol). The measurements were performed at 101.3 kPa, at temperatures between 293.15 K and 333.15 K, and for different mole ratios of the glycol and choline chloride. The viscosity was measured with a capillary viscometer, while the density was measured by means of a vibrating U-tube densimeter. The density and viscosity data have expanded relative uncertainties of 0.2% and 2.0%, respectively, with a coverage factor of 2. The viscosity of pure glycols was modeled using the extended hard-sphere (EHS) model that has its basis in kinetic theory and the molecular description of the fluid. Each DES was treated as a binary mixture, and the EHS model was used, with a mole average mixing rule, to calculate its viscosity. The measured DES viscosity data were represented with the average absolute deviation of 1.4% and a maximum deviation of 7%.

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Section: Methodsmentioning

confidence: 58%

Viscosity of Choline Chloride-Based Deep Eutectic Solvents: Experiments and Modeling

et al. 2020

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“…77 On general observation, it is concluded that density, conductivity and pH are the important essential proprties and molar solubility, excess molar volume, and spectral properties such as NMR and FTIR are the important empirical physical properties that must be determined to evaluate the suitability of the respective type of DES for nutraceutical extraction. 98 ■ SUSTAINABLE LOW-ENERGY EXTRACTION SYSTEMS WITH DES Solid−Liquid Extraction Methods Based on DES. Solid−liquid extraction method is one of the emerging sorption techniques developed to transfer target molecules from solid boundaries to liquid phase solvents by percolation.…”

Section: Effect Ofmentioning

confidence: 99%

“…However, each type of DES exhibits a signature physical property (Figure ) that influences its orientation to selectively extract a single type of nutraceutical . On general observation, it is concluded that density, conductivity and pH are the important essential proprties and molar solubility, excess molar volume, and spectral properties such as NMR and FTIR are the important empirical physical properties that must be determined to evaluate the suitability of the respective type of DES for nutraceutical extraction …”

Section: Synthesis and Characterization Of Desmentioning

confidence: 99%

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Balaraman

Rangabhashiyam

Rangarajan

et al. 2021

ACS Sustainable Chem. Eng.

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Deep eutectic solvents (DES) hold promising potential in the selective purification of bioactive molecules from various complex sources. Although they are increasingly considered as a biocompatible extraction medium, adding the task-specific functionality, which makes DES distinctive for the selective extraction of compounds, requires appropriate tailoring of their physical properties. This critical review investigates the influential physical properties of deep eutectic solvents and their effect on various sustainable extraction methodsincluding both solid–liquid and liquid–liquidfor the separation of nutraceuticals. Various methods by which DES are employed as solvents, cosolvents, or as adjuvants in different extraction systems are compared in terms of their efficiency and selectivity. Furthermore, the correspondence between the type of DES and the nature of target nutraceuticals to be extracted is also discussed. The Review highlights the key achievements and future prospects of employing DES along with the lacunae in the current investigations and proposed various approaches for sustainable applications.

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“…Equations of state are particularly promising due to the ability to describe densities and activity coefficients by taking into account explicit molecular interactions . Perturbed-Chain Statistical Associating Fluid Theory (PC-SAFT) has proven to be capable of predicting physicochemical properties of different compounds and mixtures. , PC-SAFT calculations have been successful for systems of varying complexity such as amino acids, aromatics, electrolytes, proteins, ionic liquids, and deep eutectic solvents. , Specifically, Zubeir et al proposed the individual-component approach for modeling of DES . This approach provides the flexibility to screen physical properties from DES based on their hydrogen bond acceptors (HBAs) and hydrogen bond donors (HBDs) constituents as a function of molar ratios using only pure-component parameters of HBAs and HBD.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Influence of Betaine-Based Natural Deep Eutectic Systems on Horseradish Peroxidase

Gajardo‐Parra

Meneses

Duarte

et al. 2022

ACS Sustainable Chem. Eng.

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To validate the use of horseradish peroxidase (HRP) in natural deep eutectic systems (NADES), five different betaine-based NADES were characterized in terms of water content, water activity, density, and viscosity experimentally and by thermodynamic modeling. The results show that the NADES under study have a water activity of about 0.4 at 37 °C for water contents between 14 and 22 wt %. The densities of the studied NADES had values between 1.2 and 1.3 g.cm–3 at 20 °C. The density was modeled with a state-of-the-art equation of state; an excellent agreement with the experimental density data was achieved, allowing reasonable predictions for water activities. The system betaine:glycerol (1:2) was found to be the most viscous with a dynamic viscosity of ∼600 mPa.s at 40 °C, while all the other systems had viscosities <350 mPa.s at 40 °C. The impact of the NADES on the enzymatic activity, as well as on, conformational and thermal stability was assessed. The system betaine/sorbitol:water (1:1:3) showed the highest benefit for enzymatic activity, increasing it by two-folds. Moreover, upon NADES addition, thermal stability was increased followed by an increment in a-helix secondary structure content.

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Hydrogen bond donor and alcohol chain length effect on the physicochemical properties of choline chloride based deep eutectic solvents mixed with alcohols

Cited by 50 publications

References 73 publications

Viscosity of Choline Chloride-Based Deep Eutectic Solvents: Experiments and Modeling

Viscosity of Choline Chloride-Based Deep Eutectic Solvents: Experiments and Modeling

Sustainable and Green Engineering Insights on Deep Eutectic Solvents toward the Extraction of Nutraceuticals

Assessing the Influence of Betaine-Based Natural Deep Eutectic Systems on Horseradish Peroxidase

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