Hydrogen bond-enhanced nanogel delivery system for potential intranasal therapy of Parkinson's disease

Chen, Yi-Bing; Qiao, Tao; Wang, Yanqiu; Cui, Yuan‐Lu; Wang, Qiang-Song

doi:10.1016/j.matdes.2022.110741

Cited by 16 publications

(12 citation statements)

References 52 publications

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“…The pharmacokinetic effects studied in the Parkinson's disease model. The reported work demonstrated the best compatibility of nano gels with intranasal administration route and open the doors further for nano gels application in intranasal drug delivery system 78 …”

Section: Applicationsmentioning

confidence: 82%

Recent progress in thermosensitive hydrogels and their applications in drug delivery area

Khan,

Arbab,

Khan

et al. 2023

MedComm – Biomaterials and Applications

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The scientific community has widely recognized thermosensitive hydrogels as highly biocompatible material with immense potential in drug delivery systems. When the temperature of these hydrogels approaches that of human body, a phase change occurs, enhancing their usefulness in a range of medical scenarios. This review article highlighted the background of thermosensitive hydrogels, their properties, and their applications in transdermal, oral, ophthalmic, intravaginal, nasal, rectal, cancer therapy, and cell‐loaded drug delivery systems. The literature suggests numerous advantages of these hydrogels over conventional drug delivery systems and find applications in various fields, such as therapeutic systems, filling processes, and sustained drug delivery systems. One of their key benefits is the ability to eliminate invasive procedures like surgery, providing a noninvasive alternative for drug administration. Moreover, they streamline the formulation process for both hydrophilic and hydrophobic drug delivery systems, simplifying the development of effective treatments. The thermosensitive hydrogels have been found to be green materials with negligible side effects and desirable drug delivery properties. The thermosensitive hydrogel's sustained‐release characteristics, immunogenicity, and biodegradability have also gained increased interest. Some of the disadvantages of thermosensitive hydrogels include delayed temperature response, weak mechanical characteristics, and poor biocompatibility, which limits their potential use in drug delivery applications.

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Section: Applicationsmentioning

confidence: 82%

Recent progress in thermosensitive hydrogels and their applications in drug delivery area

Khan,

Arbab,

Khan

et al. 2023

MedComm – Biomaterials and Applications

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“…This nano-hydrogel system showed improved stability and used hydrogen bonding sites for active small molecules. 55 These kinds of studies justify the potential of nanogels for…”

Section: Nanogelsmentioning

confidence: 95%

“…This nano-hydrogel showed selective brain distribution and accumulation. This nano-hydrogel system showed improved stability and used hydrogen bonding sites for active small molecules . These kinds of studies justify the potential of nanogels for sustained release carriers for PD and are capable of noninvasive drug administration.…”

Section: Nanogelsmentioning

confidence: 99%

Recent Advances in Nanotherapeutics for Neurological Disorders

Vashist

Manickam

Raymond

et al. 2023

ACS Appl. Bio Mater.

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Neurological disorders remain a significant health and economic burden worldwide. Addressing the challenges imposed by existing drugs, associated side-effects, and immune responses in neurodegenerative diseases is essential for developing better therapies. The immune activation in a diseased state has complex treatment protocols and results in hurdles for clinical translation. There is an immense need for the development of multifunctional nanotherapeutics with various properties to address the different limitations and immune interactions exhibited by the existing therapeutics. Nanotechnology has proven its potential to improve therapeutic delivery and enhance efficacy. Promising advancements have been made in developing nanotherapies that can be combined with CRISPR/Cas9 or siRNA for a targeted approach with unique potential for clinical translation. Engineering natural exosomes derived from mesenchymal stem cells (MSCs), dendritic cells (DCs), or macrophages to both deliver therapeutics and modulate the immune responses to tumors or in neurodegenerative disease (ND) can allow for targeted personalized therapeutic approaches. In the present review, we summarize and overview the recent advances in nanotherapeutics in addressing the existing treatment limitations and neuroimmune interactions for developing ND therapies and provide insights into the upcoming advancements in nanotechnology-based nanocarriers.

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“…Other nanoparticles have been also developed to modulate ROS level for PD therapy. For example, natural compounds curcumin‐loaded polysorbate 80‐modified cerasome nanoparticles, 108 curcumin analog‐based nanoparticle, 109 polydopamine and selenocystine nanocomposite, 102 glycyrrhizic acid‐zinc alginate nanogel encapsulated albiflorin 103 . Zhang et al 104 developed the BBB‐penetrating peptide (rabies virus glycoprotein 29 [RVG29]) conjugating with natural autophagy inducer 4,4′‐dimethoxychalcone to form a novel delivery system (RVG‐nDMC), which can alleviate oxidative stress in dopaminergic neurons and reverse tyrosine hydroxylase ubiquitination (Figure 4C).…”

Section: Treatment Of Pd By Advanced Nanoparticlesmentioning

confidence: 99%

“…For example, natural compounds curcumin-loaded polysorbate 80-modified cerasome nanoparticles, 108 curcumin analog-based nanoparticle, 109 polydopamine and selenocystine nanocomposite, 102 glycyrrhizic acid-zinc alginate nanogel encapsulated albiflorin. 103 Zhang et al 104 developed the BBB-penetrating peptide (rabies virus glycoprotein 29 [RVG29]) conjugating with natural autophagy inducer 4,4′-dimethoxychalcone to form a novel delivery system (RVG-nDMC), which can alleviate oxidative stress in dopaminergic neurons and reverse tyrosine hydroxylase ubiquitination (Figure 4C). 104 Amphiphilic nanoparticles modified natural exosomes, which were derived from human umbilical-cord mesenchymal stem cells (MSCs), also showed excellent capability of capturing chemical attractants (ROS and iNOS) through L-arginine derivatives on nanoparticles (Figure 4D).…”

Section: Alleviation Of Oxidative Stressmentioning

confidence: 99%

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

Liu

Hua

Zheng

et al. 2023

MedComm – Biomaterials and Applications

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With the aging of global population, the early diagnosis and treatment of neurodegenerative diseases such as Parkinson's disease (PD) have attracted considerable attention. Despite great advances achieved during the past decades, PD as the second largest neurodegenerative disease is still incurable. In the clinical practice, PD patients are mainly treated by drugs, and supplemented with deep brain stimulation or nerve nucleus destruction. The existing drugs can only relieve the symptoms of motor disorder, and cannot stop the progression of PD. Compared with small molecular drugs, nanoparticles exhibit multiple functions in the neuroprotection and neurorepair due to their tunable physical and chemical properties, easy modification and functionalization. Herein, we first briefly review the characteristics of nanoparticles crossing the blood–brain barrier, which is a primary challenge for the treatment of PD. Then, we summarize the pathologic mechanisms of PD and comprehensively discuss the novel PD therapy based on diverse nanoparticles, including alleviating oxidative stress, scavenging α‐synuclein aggregates, chelating metal ions, delivering neurotrophic factors and genes, and transplanting stem cells. This review aims to highlight the great potential of advanced nanoparticles in the therapy of PD.

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Hydrogen bond-enhanced nanogel delivery system for potential intranasal therapy of Parkinson's disease

Cited by 16 publications

References 52 publications

Recent progress in thermosensitive hydrogels and their applications in drug delivery area

Recent progress in thermosensitive hydrogels and their applications in drug delivery area

Recent Advances in Nanotherapeutics for Neurological Disorders

Targeting the pathogenesis and boosting the therapeutic efficacy of Parkinson's disease by advanced nanoparticles

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