Hydrogen‐Bond Free Energy of Local Biological Water

Park, Won‐Woo; Lee, Kyung Min; Lee, Byeong Sung; Kim, Young Jae; Joo, Se Hun; Kwak, Sang Kyu; Yoo, Tae Hyeon; Kwon, Oh‐Hoon

doi:10.1002/anie.202002025

Cited by 7 publications

(2 citation statements)

References 53 publications

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“…Moreover, Chou and co-workers demonstrated that 2,7-diazaindole (2,7-diazatryptophan) is a useful fluorescence reporter of the protein local hydration status, because it gives rise to multiple emissions that are sensitive to the water environment. The spectroscopic utilities of these azatryptophans have been demonstrated in various studies. − ,− For example, Schwabacher, Petrich, and co-workers demonstrated that 7AW can be used to probe small molecule–protein interactions on the picosecond time scale. Eggleston and co-workers devised a fluorescence assay that uses a 7AW-containing peptide to detect free heme in solution.…”

Section: Fluorescence Probesmentioning

confidence: 99%

“…Eggleston and co-workers devised a fluorescence assay that uses a 7AW-containing peptide to detect free heme in solution. Kwon and co-workers used 7AW, whose chromophore can undergo a solvent-assisted excited-state-proton transfer (ESPT) process, , as a fluorescence reporter to assess the H-bond free energy of water at protein surfaces. Budisa and co-workers used both 4AW and 7AW to evaluate the role a Trp residue in the folding of an enhanced cyan fluorescent protein (ECFP).…”

Section: Fluorescence Probesmentioning

confidence: 99%

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Unnatural Amino Acids for Biological Spectroscopy and Microscopy

Feng,

Wang,

Zhang

et al. 2024

Chem. Rev.

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Due to advances in methods for site-specific incorporation of unnatural amino acids (UAAs) into proteins, a large number of UAAs with tailored chemical and/or physical properties have been developed and used in a wide array of biological applications. In particular, UAAs with specific spectroscopic characteristics can be used as external reporters to produce additional signals, hence increasing the information content obtainable in protein spectroscopic and/or imaging measurements. In this Review, we summarize the progress in the past two decades in the development of such UAAs and their applications in biological spectroscopy and microscopy, with a focus on UAAs that can be used as site-specific vibrational, fluorescence, electron paramagnetic resonance (EPR), or nuclear magnetic resonance (NMR) probes. Wherever applicable, we also discuss future directions.

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Section: Fluorescence Probesmentioning

confidence: 99%

Section: Fluorescence Probesmentioning

confidence: 99%

Unnatural Amino Acids for Biological Spectroscopy and Microscopy

Feng,

Wang,

Zhang

et al. 2024

Chem. Rev.

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Hydrogen‐Binding‐Initiated Activation of O−H Bonds on a Nitrogen‐Doped Surface for the Catalytic Oxidation of Biomass Hydroxyl Compounds

Liu

Luo

et al. 2021

Angewandte Chemie

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Hydrogen binding of molecules on solid surfaces is an attractive interaction that can be used as the driving force for bond activation, material‐directed assembly, protein protection, etc. However, the lack of a quantitative characterization method for hydrogen bonds (HBs) on surfaces seriously limits its application. We measured the standard Gibbs free energy change (ΔG0) of on‐surface HBs using NMR. The HB‐accepting ability of the surface was investigated by comparing ΔG0 values employing the model biomass platform 5‐hydroxymethylfurfural on a series of Co‐N‐C‐n catalysts with adjustable electron‐rich nitrogen‐doped contents. Decreasing ΔG0 improves the HB‐accepting ability of the nitrogen‐doped surface and promotes the selectively initiated activation of O−H bonds in the oxidation of 5‐hydroxymethylfurfural. As a result, the reaction kinetics is accelerated. In addition to the excellent catalytic performance, the turnover frequency (TOF) for this oxidation is much higher than for reported non‐noble‐metal catalysts.

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Hydrogen‐Binding‐Initiated Activation of O−H Bonds on a Nitrogen‐Doped Surface for the Catalytic Oxidation of Biomass Hydroxyl Compounds

Liu

Luo

et al. 2021

Angew Chem Int Ed

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Hydrogen binding of molecules on solid surfaces is an attractive interaction that can be used as the driving force for bond activation, material-directed assembly,p rotein protection, etc. However,t he lacko faq uantitative characterization method for hydrogen bonds (HBs) on surfaces seriously limits its application. We measured the standardG ibbsf ree energy change (DG 0 )o fo n-surface HBs using NMR. The HBaccepting ability of the surface was investigated by comparing DG 0 values employing the model biomass platform 5-hydroxymethylfurfural on aseries of Co-N-C-n catalysts with adjustable electron-richn itrogen-doped contents.D ecreasing DG 0 improves the HB-accepting ability of the nitrogen-doped surface and promotes the selectively initiated activation of OÀHb onds in the oxidation of 5-hydroxymethylfurfural. As ar esult, the reaction kinetics is accelerated. In addition to the excellent catalytic performance,the turnover frequency (TOF) for this oxidation is muchhigher than for reported non-noblemetal catalysts.

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Hydrogen‐Bond Free Energy of Local Biological Water

Cited by 7 publications

References 53 publications

Unnatural Amino Acids for Biological Spectroscopy and Microscopy

Unnatural Amino Acids for Biological Spectroscopy and Microscopy

Hydrogen‐Binding‐Initiated Activation of O−H Bonds on a Nitrogen‐Doped Surface for the Catalytic Oxidation of Biomass Hydroxyl Compounds

Hydrogen‐Binding‐Initiated Activation of O−H Bonds on a Nitrogen‐Doped Surface for the Catalytic Oxidation of Biomass Hydroxyl Compounds

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