Hydrogen-bond super-amphiphile based drug delivery system: design, synthesis, and biological evaluation

Chen, Jiali; Huang, Handong; Lu, Ruilin; Wan, Xiaohui; Yao, Yongchao; Tian, Yang; Li, Pengfei; Ning, Ning; Zhang, Shiyong

doi:10.1039/d1ra08624c

Cited by 2 publications

(2 citation statements)

References 34 publications

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“…The presence of both cationic elements and organic bridges in their structure boosts a wide range of interactions between the MOF and the target drug including electrostatic, covalent, and hydrogen bonds, leading to a successful drug entrapment within the MOF network. [76][77][78] For instance, effective encapsulation of 5-FU within the structure of ZIF-8 and IRMOF-3 has been reported in the literature. [68,74] The fluorine atoms of 5-FU and the hydrogen atoms of the organic ligands can form H-bonds that stabilize the drug-MOF complex.…”

Section: Enzyme-responsivementioning

confidence: 99%

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Pourmadadi

Ostovar

Eshaghi

et al. 2023

Applied Organom Chemis

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Recently, metal-organic frameworks (MOFs) have received a lot of interest for application in many fields ranging from catalysis, energy storage, and gas sensing to chemosensory and biomedicine owed to their flexible composition, tunable porosity, and easy functionalization ability. In particular, nanoscale MOFs have been broadly investigated as carriers for the delivery of therapeutics to cancerous organs owed to their high encapsulating capacity and controlled cargo release, versatility, biodegradability, and good biocompatibility.Several methods such as solvothermal, mechanochemical, electrochemical, microwave, and ultrasound have been utilized to fabricate MOFs via custommade synthesis. Many efforts have been made to functionalize MOFs through "post-synthetic modification," by adjusting the nature, size, and charge of the linkers or tuning its main components. Herein, a comprehensive literature review on recent papers dealing with drug-loaded MOFs for the detection and treatment of cancer as well as bacterial, fungal, and viral infections is presented. Different types of MOFs applied as carriers in drug delivery systems and biosensing platforms are described. Furthermore, perspectives and challenges for future research in the field, particularly for cancer therapy, are discussed. Thus, very limited literature is available on in vitro and in vivo toxicity of nanoscale MOFs. Besides, their biological stability and long-term safety are crucial factors that should be further investigated. Based on the reviewed papers, zeolite imidazolate framework (ZIF) and Materials of Institute Lavoisier (MIL) families have been the main focus for drug delivery and diagnosis applications, respectively, while many types of MOFs have exhibited antibacterial and antifungal properties regardless of their cargo.

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Section: Enzyme-responsivementioning

confidence: 99%

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Pourmadadi

Ostovar

Eshaghi

et al. 2023

Applied Organom Chemis

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“…In order to overcome these challenges, carrier-based drug delivery systems (DDSs) have been developed. Such systems have shown promise as an effective strategy to enhance therapeutic efficiency due to their ability to achieve high drug-loading capacities and facilitate sustained drug release [ 1 ]. Drug delivery systems refer to the use of carriers to transport drugs and control their release and distribution within the human body.…”

Section: Introductionmentioning

confidence: 99%

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Song,

Aipire,

Dilxat

et al. 2024

Pharmaceutics

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Clinical drug administration aims to deliver drugs efficiently and safely to target tissues, organs, and cells, with the objective of enabling their therapeutic effects. Currently, the main approach to enhance a drug’s effectiveness is ensuring its efficient delivery to the intended site. Due to the fact that there are still various drawbacks of traditional drug delivery methods, such as high toxicity and side effects, insufficient drug specificity, poor targeting, and poor pharmacokinetic performance, nanocarriers have emerged as a promising alternative. Nanocarriers possess significant advantages in drug delivery due to their size tunability and surface modifiability. Moreover, nano-drug delivery systems have demonstrated strong potential in terms of prolonging drug circulation time, improving bioavailability, increasing drug retention at the tumor site, decreasing drug resistance, as well as reducing the undesirable side effects of anticancer drugs. Numerous studies have focused on utilizing polysaccharides as nanodelivery carriers, developing delivery systems based on polysaccharides, or exploiting polysaccharides as tumor-targeting ligands to enhance the precision of nanoparticle delivery. These types of investigations have become commonplace in the academic literature. This review aims to elucidate the preparation methods and principles of polysaccharide gold nanocarriers. It also provides an overview of the factors that affect the loading of polysaccharide gold nanocarriers with different kinds of drugs. Additionally, it outlines the strategies employed by polysaccharide gold nanocarriers to improve the delivery efficiency of various drugs. The objective is to provide a reference for further development of research on polysaccharide gold nanodelivery systems.

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Hydrogen-bond super-amphiphile based drug delivery system: design, synthesis, and biological evaluation

Abstract: Drug delivery systems (DDSs) show great application prospects in tumor therapy.

Cited by 2 publications

References 34 publications

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Nanoscale metallic‐organic frameworks as an advanced tool for medical applications: Challenges and recent progress

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

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