Hydrogen-bonded co-crystal structure of benzoic acid and zwitterionicL-proline

Abstract

Benzoic acid–pyrrolidin-1-ium-2-carboxyl­ate (1/1) is an example of the application of non-centrosymmetric co-crystallization for the growth of a crystal containing a typically centrosymmetric component in a chiral space group. It co-crystallizes in the space group P212121 and contains benzoic acid and l-proline in equal proportions. The crystal structure exhibits chains of l-proline zwitterions capped by benzoic acid mol­ecules which form a C(5)[(11)] hydrogen-bonded network along [100].

Syntheses and crystal structures of hydrated and anhydrous 1:2 cocrystals of oxyresveratrol and zwitterionic proline

“…It is an osmoprotectant and is used frequently in many pharmacological and biotechnological applications (Panday, 2011). PRO has been used as a cocrystal former in various drugs and pharmacological active compounds because of its molecular rigidity and high solubility in water (Chesna et al, 2017;Surov et al, 2018;Tilborg et al, 2014). According to previous studies, the phenolic hydroxyl groups of flavonoids are able to form charge-assisted hydrogen bonds with the carboxylate moiety of PRO (He et al, 2016).…”