Hydrogen-bonded multilayer of pH-responsive polymeric micelles with tannic acid for surface drug delivery

Kim, Byeong Su; Lee, Hyungyil; Min, Yunhong; Poon, Zhiyong; Hammond, Paula T.

doi:10.1039/b908688a

Cited by 147 publications

(118 citation statements)

References 28 publications

(41 reference statements)

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“…20,26 Applications envisioned for such drug-loaded films include antimicrobial-or anti-inflammatory coatings on implants and drug-releasing coatings for stents. 24,27,28 Given the ability of multilayers to be conformally coated on a broad range of substrates, to load both small-molecule and macromolecular drugs, and to regulate the release of drugs over a period of hours to days, we became interested in the potential of these polyelectrolyte films in a new application area: transcutaneous drug delivery. Skin is an attractive site for non-invasive delivery of therapeutics, due to the ease of access to this organ and the ability of transcutaneous delivery to limit first-pass drug metabolism and alter the pharmacokinetics and pharmacodynamics of drugs.…”

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confidence: 99%

Layer-by-Layer-Assembled Multilayer Films for Transcutaneous Drug and Vaccine Delivery

Su¹,

Kim²,

Kim³

et al. 2009

ACS Nano

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We describe protein-and oligonucleotide-loaded layer-by-layer (LbL)-assembled multiplayer films incorporating a hydrolytically degradable polymer for transcutaneous drug or vaccine delivery. Films were constructed based on electrostatic interactions between a cationic poly(β-amino ester) (denoted Poly-1) with a model protein antigen, ovalbumin (ova), and/or immunostimulatory CpG (Cytosine-phosphate diester-Guanine rich) DNA oligonucleotide adjuvant molecules. Linear growth of nanoscale Poly-1/ova bilayers was observed. Dried ova protein-loaded films rapidly deconstructed when rehydrated in saline solutions, releasing ova as non-aggregated/non-degraded protein, suggesting that the structure of biomolecules integrated into these multilayer films are preserved during release. Using confocal fluorescence microscopy and an in vivo murine ear skin model, we demonstrated delivery of ova from LbL films into barrierdisrupted skin, uptake of the protein by skin-resident antigen-presenting cells (Langerhans cells), and transport of the antigen to the skin-draining lymph nodes. Dual incorporation of ova and CpG oligonucleotides into the nanolayers of LbL films enabled dual release of the antigen and adjuvant with distinct kinetics for each component; ova was rapidly released while CpG was released in a relatively sustained manner. Applied as skin patches, these films delivered ova and CpG to Langerhans Cells in the skin. To our knowledge, this is the first demonstration of LbL films applied for the delivery of biomolecules into skin. This approach provides a new route for storage of vaccines and other immunotherapeutics in a solid-state thin film for subsequent delivery into the immunologically-rich milieu of the skin.

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confidence: 99%

Layer-by-Layer-Assembled Multilayer Films for Transcutaneous Drug and Vaccine Delivery

Su¹,

Kim²,

Kim³

et al. 2009

ACS Nano

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156

120

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“…On the other hand, tannin coatings can exhibit antibacterial, antimutagenic or antimicrobial effects [18][19][20]. There has also been an increasing interest in H-bonded assembly of tannic acid with several neutral polymers, including poly(Nvinylpyrrolidone), for the development of physiologically stable thin films and hollow capsules for controlled drug release (since tannin can be a model polyphenolic drug) and other biotechnology applications [21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Layer-by-layer assembly of thin organic films on PTFE activated by cold atmospheric plasma

et al. 2014

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An air diffuse coplanar surface barrier discharge is used to activate the surface of polytetrafluoroethylene (PTFE) samples, which are subsequently coated with polyvinylpyrrolidone (PVP) and tannic acid (TAN) single, bi-and multilayers, respectively, using the dipcoating method. The surfaces are characterized by X-ray Photoelectron Spectroscopy (XPS), Attenuated Total Reflection -Fourier Transform Infrared Spectroscopy (ATR-FTIR) and Atomic Force Microscopy (AFM). The XPS measurements show that with plasma treatment the F/C atomic ratio in the PTFE surface decreases, due to the diminution of the concentration of CF 2 moieties, and also oxygen incorporation through formation of new C-O, C=O and O=C-O bonds can be observed. In the case of coated samples, the new bonds indicated by XPS show the bonding between the organic layer and the surface, and thus the stability of layers, while the gradual decrease of the concentration of F atoms with the number of deposited layers proves the creation of PVP/TAN bi-and multi-layers. According to the ATR-FTIR spectra, in the case of PVP/TAN multilayer hydrogen bonding develops between the PVP and TAN, which assures the stability of the multilayer. The AFM lateral friction measurements show that the macromolecular layers homogeneously coat the plasma treated PTFE surface.

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“…Biofilm encroachment on biomaterial is an important concern postsurgery. In the past, several studies of modifying surfaces have shown that pH-sensitive polyelectrolyte multilayers can be effectively used to release therapeutics at a specific pH (24,46). Drugs are incorporated within weak polyelectrolyte assemblies at low pH due to hydrogen bonding of the small molecule with the matrix to form thin multilayers.…”

mentioning

confidence: 99%

Identification of a Novel Benzimidazole That Inhibits Bacterial Biofilm Formation in a Broad-Spectrum Manner

Sambanthamoorthy

Gokhale

Lao

et al. 2011

Antimicrob Agents Chemother

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Bacterial biofilm formation causes significant industrial economic loss and high morbidity and mortality in medical settings. Biofilms are defined as multicellular communities of bacteria encased in a matrix of protective extracellular polymers. Because biofilms have a high tolerance for treatment with antimicrobials, protect bacteria from immune defense, and resist clearance with standard sanitation protocols, it is critical to develop new approaches to prevent biofilm formation. Here, a novel benzimidazole molecule, named antibiofilm compound 1 (ABC-1), identified in a small-molecule screen, was found to prevent bacterial biofilm formation in multiple Gram-negative and Gram-positive bacterial pathogens, including Pseudomonas aeruginosa and Staphylococcus aureus, on a variety of different surface types. Importantly, ABC-1 itself does not inhibit the growth of bacteria, and it is effective at nanomolar concentrations. Also, coating a polystyrene surface with ABC-1 reduces biofilm formation. These data suggest ABC-1 is a new chemical scaffold for the development of antibiofilm compounds.

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Hydrogen-bonded multilayer of pH-responsive polymeric micelles with tannic acid for surface drug delivery

Abstract: We report the design of a platform for the delivery of hydrophobic drugs conjugated to block copolymer micelles via pH-responsive linkage that are assembled within hydrogen bonded polymer multilayer thin films.

Cited by 147 publications

References 28 publications

Layer-by-Layer-Assembled Multilayer Films for Transcutaneous Drug and Vaccine Delivery

Layer-by-Layer-Assembled Multilayer Films for Transcutaneous Drug and Vaccine Delivery

Layer-by-layer assembly of thin organic films on PTFE activated by cold atmospheric plasma

Identification of a Novel Benzimidazole That Inhibits Bacterial Biofilm Formation in a Broad-Spectrum Manner

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