Hydrogen bonds of interfacial water in human breast cancer tissue compared to lipid and DNA interfaces

Abramczyk, Halina; Brożek-Płuska, Beata; Surmacki, Jakub; Jablonska-Gajewicz, Joanna; Kordek, Radzisław

doi:10.4236/jbpc.2011.22020

Cited by 20 publications

(20 citation statements)

References 97 publications

(116 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In 2011, Abramczyk et al presented the first Raman "optical biopsy" images of the non-cancerous and cancerous (infiltrating ductal cancer) human breast tissue [277]. A marked red-shift of the maximum peak position of the OH stretching mode was observed confirming that the vibrational properties of the interfacial water observed in restricted biological environments differs drastically from those in bulk water.…”

Section: Breast Cancermentioning

confidence: 88%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

View full text Add to dashboard Cite

This paper postulates that water structure is altered by biomolecules as well as by disease-enabling entities such as certain solvated ions, and in turn water dynamics and structure affect the function of biomolecular interactions. Although the structural and dynamical alterations are subtle, they perturb a well-balanced system sufficiently to facilitate disease. We propose that the disruption of water dynamics between and within cells underlies many disease conditions. We survey recent advances in magnetobiology, nanobiology, and colloid and interface science that point compellingly to the crucial role played by the unique physical properties of quantum coherent nanomolecular clusters of magnetized water in enabling life at the cellular level by solving the "problems" of thermal diffusion, intracellular crowding, and molecular self-assembly. Interphase water and cellular surface tension, normally maintained by biological sulfates at membrane surfaces, are compromised by exogenous interfacial water stressors such as cationic aluminum, with consequences that include greater local water hydrophobicity, increased water tension, and interphase stretching. The ultimate result is greater "stiffness" in the extracellular matrix and either the "soft" cancerous state or the "soft" neurodegenerative state within cells. Our hypothesis provides a basis for understanding why so many idiopathic diseases of today are highly stereotyped and pluricausal. OPEN ACCESSEntropy 2013, 15 3823

show abstract

Section: Breast Cancermentioning

confidence: 88%

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Davidson¹,

Lauritzen

Seneff

2013

Entropy

View full text Add to dashboard Cite

show abstract

“…They contain no blood vessels, so nourishment is provided via diffusion of substances from the connective tissue ( Figure 4b). The surface of the cancerous tissue is hydro philic, 100 and the level of various proteins is markedly elevated during disease development.…”

Section: Resultsmentioning

confidence: 99%

“…99 In contrast, cancerous tissue is dominated by epithelial cells, which produce milk and are lined with the ducts of the breast (Figure 4b). The surface of cancerous tissue is hydrophilic, 100 and the level of various proteins is markedly elevated during disease development. We found 100 that water amount confined in cancerous tissue is markedly higher than that in noncancerous tissue.…”

Section: Discussionmentioning

confidence: 99%

“…The surface of cancerous tissue is hydrophilic, 100 and the level of various proteins is markedly elevated during disease development. We found 100 that water amount confined in cancerous tissue is markedly higher than that in noncancerous tissue. Our results provide experimental evidence for the role played by the lipid profile and cell hydration as factors of particular significance in differentiation of noncancerous and cancerous breast tissues.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Ultrafast Dynamics of Metal Complexes of Tetrasulfonated Phthalocyanines at Biological Interfaces: Comparison between Photochemistry in Solutions, Films, and Noncancerous and Cancerous Human Breast Tissues

et al. 2013

Self Cite

View full text Add to dashboard Cite

A promising material in medicine, electronics, opto electronics, electrochemistry, catalysis, and photophysics, Al(III) phthalocyanine chloride tetrasulfonic acid (AlPcS 4 ) is investigated at biological interfaces of human breast tissue by means of steady state and time resolved pump−probe spectroscopies: IR, Raman, UV−vis, fluorescence, and electronic transient absorption by pump−probe spectroscopy. Spectrally resolved pump−probe data were recorded on time scales ranging from femtoseconds to nanoseconds and give insight into molecular interactions and primary events in the interfacial region. The nature of these fast processes and pathways of the competing relaxation processes from the initially excited electronic states in AlPcS 4 films and at biological interfaces of human breast cancerous and noncancerous tissues is studied. Comparison between photochemical dynamics in the biological environment of the human breast tissues and that occurring in aqueous solutions is presented. The excited state absorption (ESA) decays and bleaching recovery of the ground state have been fitted in the time window extending to nanoseconds (0−1 ns). We found that the excited state dynamics of AlPcS 4 at biological interfaces of human breast tissue is extremely sensitive to the biological environment and differs drastically from that observed in solutions and films. We demonstrated that the ultrafast dynamics at biological interfaces is described by three time constants in the ranges of 110−170 fs, 1−7 ps, and 20−60 ps. We were able to ascribe these three time constants to the primary events occurring in phthalocyanine at biological interfaces. The shortest time constants have been assigned to vibrational wavepacket dynamics in the Franck−Condon region down to the local minimum of the excited state S 1 . The 1−7 ps components have been assigned to vibrational relaxation in the excited and ground electronic states. In contrast to the dynamics observed in aqueous solutions with the components in the range of 150−500 ps assigned to decay from S 1 to the ground electronic state, these slow components have not been recorded in human breast tissue. We have shown that the lifetimes characterizing the first excited state S 1 in the interfacial regions of the breast tissue are markedly shorter than those in solution. It suggests that molecular structures responsible for harvesting of the light energy in biological tissue find their own ways for recovery through some special features of the potential energy surfaces such as conical intersections, which facilitate the rate of radiationless transitions. We found that the dynamics of photosensitizers in normal (noncancerous) breast tissue is markedly faster than that in cancerous tissue.

show abstract

“…Полосы в области 4000−3750 cm −1 относятся к антисимметричным колебаниям свободных гидроксилов [34,35]. Диффузная полоса 2960−2900 сm [37][38][39][40].…”

Section: результаты экспериментаunclassified

Исследование Индукционно-Резонансного Взаимодействия Кластеров Воды В Минералах Фторапатита Методами Поляризационной ИК И Кр-Спектроскопии

Золотарев¹

2018

Журнал Технической Физики

View full text Add to dashboard Cite

Hydrogen bonds of interfacial water in human breast cancer tissue compared to lipid and DNA interfaces

Cited by 20 publications

References 97 publications

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Biological Water Dynamics and Entropy: A Biophysical Origin of Cancer and Other Diseases

Ultrafast Dynamics of Metal Complexes of Tetrasulfonated Phthalocyanines at Biological Interfaces: Comparison between Photochemistry in Solutions, Films, and Noncancerous and Cancerous Human Breast Tissues

Исследование Индукционно-Резонансного Взаимодействия Кластеров Воды В Минералах Фторапатита Методами Поляризационной ИК И Кр-Спектроскопии

Contact Info

Product

Resources

About