Hydrogen breath test to detect small intestinal bacterial overgrowth: a prevalence case–control study in autism

Wang, Li; Yu, Yu-Mei; Zhang, You-qi; Zhang, Jie; Lü, Na; Liu, Na

doi:10.1007/s00787-017-1039-2

Cited by 34 publications

(24 citation statements)

References 38 publications

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“…Increased levels of antibodies against food antigens has also been demonstrated in ASD (Table 1 ). In general, this disorder is characterized by high comorbidity of various gastrointestinal abnormalities e.g., constipation, diarrhea, reflux, esophagitis, gastritis, duodenitis, enterocolitis, lymphoid nodular hyperplasia, increased intestinal permeability, impaired detoxification (for example, defective sulfation of phenolic amines), SIBO, dysbiosis with bacterial overgrowth and yeast overgrowth ( 143 – 145 ). For instance, patients with ASD had increased parameters of intestinal permeability measured with lactulose/mannitol ratio (LA/MA) and they had elevated levels IgG to AGA, deamidated gliadin and IgG to casein ( 97 ).…”

Section: Food Derived Antigens In Psychiatric Disordersmentioning

confidence: 99%

“…Additionally, fecal microbiota transplant from patients with major depression to germ free (GF) mice resulted in depression-like behavior in recipient mice ( 227 ). Small intestine bacterial overgrowth (SIBO) is another abnormality of intestinal flora observed in ASD and alcoholism ( 145 , 228 ). It was hypothesized that these alterations could play a significant role in psychopathology and assessment of flora composition could become a clinical marker in psychiatry.…”

Section: Intestinal Microbiota—new Instrument In Psychiatric Treatmenmentioning

confidence: 99%

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“Immune Gate” of Psychopathology—The Role of Gut Derived Immune Activation in Major Psychiatric Disorders

Rudzki

Szulc

2018

Front. Psychiatry

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Interaction between the gastrointestinal tract (GI) and brain functions has recently become a topic of growing interest in psychiatric research. These multidirectional interactions take place in the so-called gut-brain axis or more precisely, the microbiota-gut-brain axis. The GI tract is the largest immune organ in the human body and is also the largest surface of contact with the external environment. Its functions and permeability are highly influenced by psychological stress, which are often a precipitating factor in the first episode, reoccurrence and/or deterioration of symptoms of psychiatric disorders. In recent literature there is growing evidence that increased intestinal permeability with subsequent immune activation has a major role in the pathophysiology of various psychiatric disorders. Numerous parameters measured in this context seem to be aftermaths of those mechanisms, yet at the same time they may be contributing factors for immune mediated psychopathology. For example, immune activation related to gut-derived bacterial lipopolysaccharides (LPS) or various food antigens and exorphins were reported in major depression, schizophrenia, bipolar disorder, alcoholism and autism. In this review the authors will summarize the evidence and roles of such parameters and their assessment in major psychiatric disorders.

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Section: Food Derived Antigens In Psychiatric Disordersmentioning

confidence: 99%

Section: Intestinal Microbiota—new Instrument In Psychiatric Treatmenmentioning

confidence: 99%

“Immune Gate” of Psychopathology—The Role of Gut Derived Immune Activation in Major Psychiatric Disorders

Rudzki

Szulc

2018

Front. Psychiatry

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“…10 A recent study showed a higher prevalence of small intestinal bacterial overgrowth (SIBO) in ASD patients compared to controls, associated to worse behavioral manifestations. 31 SIBO consists in an increase in number and/or alteration in type of bacteria colonizing the small bowel.…”

Section: Gut Dysbiosis and Asdmentioning

confidence: 99%

The role of microbiota in autism spectrum disorders

Campion¹,

Ponzo²,

Alessandria³

et al. 2018

Minerva Gastroenterol Dietol

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Autism Spectrum Disorder (ASD) defines a set of neurodevelopmental disorders characterized by persistent deficits in social communication and interaction, along with repetitive patterns of behavior. Symptoms generally appear in the early developmental period and cause significant impairment in individual and social functioning. In recent years the increased prevalence of ASD, along with the evidence of a significant link between autism and gastrointestinal (GI) disturbances, raised a special interest in exploring the reciprocal influences between gut and brain. Investigators highlighted the existence of a so-called "gut-brain axis", empowering the hypothesis that GI abnormalities could trigger neuropsychiatric symptoms in ASD. Intestinal microbiota is thought to play a pivotal role in gut and systemic homeostasis, in CNS development, as well as in behavioral modulation and recurrent microbial imbalances have been shown in gut microbiota of autistic people. In this review we analyze current knowledge about intestinal microbiota and the relevance and role of dysbiosis in ASD. The most accredited theories about gut-brain interaction will be reviewed, along with current scientific evidence supporting the relationship between microbial imbalances and impairment of neurodevelopment. Finally, we will focus on the results of different therapeutic approaches in this context: administration of pre-and probiotics, antibiotics, fecal microbiota transplantation and special diets and dietary supplements.

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“…Interestingly, SIBO has been found in up to 31% of children with autism spectrum disorder as compared to only 9% of children without this disorder. 32 In our cohort, 3 out of 15 children with autism had SIBO.…”

Section: Discussionmentioning

confidence: 76%

Gastrointestinal Conditions in Children With Severe Feeding Difficulties

Rivera-Nieves

Conley

Nagib

et al. 2019

Global Pediatric Health

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Feeding aversion in children may progress to severe feeding difficulties. While oral-motor and sensory issues are usually the leading causes, organic etiologies should be considered. This study aimed to assess the prevalence of gastrointestinal conditions in children with severe feeding difficulties. We conducted a retrospective study of 93 children requiring an intensive feeding program. The medical records, radiologic and diagnostic tests, use of gastric tube feedings, preexisting medical conditions, and medications were reviewed. Fifty-two percent (52%) had esophagitis, 26.2% gastritis, and 40.7% lactase deficiency in upper endoscopy. In those who underwent an upper endoscopy, 26% of patients that were also tested for small intestinal bacterial overgrowth were found to be positive. Allergy testing was abnormal in 56.6% of those tested, while 27.5% and 75% had abnormal gastric emptying times and pH impedance results, respectively. Constipation was present in 76.3%. Thirteen of 32 were weaned off tube feedings. We conclude that gastrointestinal conditions are common in children with feeding disorders and should be investigated prior to feeding therapy.

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Hydrogen breath test to detect small intestinal bacterial overgrowth: a prevalence case–control study in autism

Cited by 34 publications

References 38 publications

“Immune Gate” of Psychopathology—The Role of Gut Derived Immune Activation in Major Psychiatric Disorders

“Immune Gate” of Psychopathology—The Role of Gut Derived Immune Activation in Major Psychiatric Disorders

The role of microbiota in autism spectrum disorders

Gastrointestinal Conditions in Children With Severe Feeding Difficulties

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